Effect of Screening and Adjuvant Therapy on Mortality From Breast Cancer

Berry, Donald A.; Cronin, Kathleen A.; Plevritis, Sylvia K.; Fryback, Dennis G.; Clarke, Lauren; Zelen, Marvin; Mandelblatt, Jeanne S.; Yakovlev, Andrei; Habbema, J. Dik F.; Feuer, Eric J.

doi:10.1097/01.ogx.0000201966.23445.91

Cited by 376 publications

(444 citation statements)

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“…The primary domain today remains mammography screening. Although there still is conflicting evidence on the overall impact of mammography screening of large cohorts, positive effects concerning mortality and survival have been reported [14]. Recently multislice CT has been proposed for screening purposes, targeting early manifestations of colon and lung cancer [15,16].…”

Section: Whole-body Imaging In Surveillance Of Cancer Patientsmentioning

confidence: 99%

Whole-body MRI and PET-CT in the management of cancer patients

et al. 2006

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Mortality rate, prognosis, and treatment outcome of cancer patients depend strongly on the detection of malignancy at an early stage and efficient monitoring of the disease. Multimodality diagnostic approaches are now widely applied for tumor detection, staging, and follow-up. However, the introduction of whole-body imaging modalities into clinical practice has substantially expanded diagnostic options. PET-CT has increased diagnostic accuracy by providing "anatometabolic" information by fusing tumor glucose-uptake measures from the PET examination and accurate delineation of anatomical structures given by spiral CT. Since PET-CT is associated with high doses of ionizing radiation, it is used in mainly tumor staging and screening within the scope of tertiary prevention. Here promising results have been reported for various tumor entities. MRI provides excellent tissue contrast, detailed morphological information and lack of ionizing radiation. MRI has been employed for the assessment of focal pathologies in specific anatomical regions. Whole-body MRI scanners using multiple receiver channels with parallel acquisition techniques now allow tumor screening from head to toe within substantially shorter examination times and without compromises in image resolution. We report our experience with these two novel techniques and discuss their benefits and drawbacks in terms of systemic tumor screening.

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Section: Whole-body Imaging In Surveillance Of Cancer Patientsmentioning

confidence: 99%

Whole-body MRI and PET-CT in the management of cancer patients

et al. 2006

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“…Between one third and one half of documented mortality reductions for breast cancer are attributed to screening [14], but a recent analysis from Norway suggests that only 10% of the decrease in breast cancer specific mortality results from screening per se, with the remainder due to improvements in systemic treatments and the formalization of multidisciplinary care [15].…”

Section: Halstedian Paradigmmentioning

confidence: 99%

Breast Cancer Local Therapy: What Is Its Effect on Mortality?

Benson

Teo

2012

World j. surg.

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Until recently, the concept of biological predeterminism appeared pre-eminent and a worthy successor to the Halstedian doctrine of centrifugal spread of cancer. However, evidence has now emerged from clinical trials to cast doubt on the universal application of this concept to breast tumors. Prevention of local recurrence can save lives, local control does matter, and rates of local recurrence should be minimized in the first 5 years. In up to one quarter of cases of local recurrence the locally recurring disease will be a determinant and not simply a marker of risk for distant relapse and death. Both types of local recurrence are manifestations of the same biological processes and reflect intrinsic behavior of the tumor. This principle applies to reduction in local relapse from both adjuvant radiotherapy and surgical modalities.

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“…B. das Sterberisiko innerhalb der ersten 10 Jahre, deutlich gesenkt werden [2]. [9], muss dieses Vorgehen kritisch über-dacht werden.…”

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