Effect of <scp>PUVA</scp> therapy on melanocytes and keratinocytes in non‐segmental vitiligo: histopathological, immuno‐histochemical and ultrastructural study

Anbar, Tag S.; El-Sawy, Ashraf E; Attia, Sameh K.; Barakat, Manal; Moftah, Noha H.; El-Ammawy, Tarek S.; Abdel‐Rahman, Amal T.; El-Tonsy, Mohamed Hany

doi:10.1111/j.1600-0781.2011.00631.x

Cited by 30 publications

(19 citation statements)

References 14 publications

(27 reference statements)

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“…Permanent oxidative disequilibrium caused by an intrinsic defect as in vitiligo skin may also prevent melanocyte regeneration and lead to a vicious circle. In fact, even if several studies revealed the presence of some melanocytes in depigmented skin, it is conceivable that the persistence of a hostile environment does not allow the complete return of functional melanocytes.…”

Section: Discussionmentioning

confidence: 99%

Extracellular fraction of adipose tissue as an innovative regenerative approach for vitiligo treatment

Bellei

Papaccio

Filoni

et al. 2019

Experimental Dermatology

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Vitiligo is a common, disfiguring autoimmune disease that negatively affects patients’ self‐esteem and quality of life. Current treatments are moderately effective in reversing disease and promoting melanocyte regeneration. Thus, therapeutic advanced strategies are emerging from regenerative medicine. It has recently emerged that adipose tissue secretome may be used as a cell‐free therapy in skin regeneration since paracrine functions of adipose‐derived stem cells alone are responsible for most of the therapeutic effect of stem cells in several animal disease models. In this study, we tested the effect of adipose tissue extracellular fraction (AT‐Ex) isolated from lipoaspirates on dermal and epidermal vitiligo cells in vitro. Using this experimental model, we demonstrated that molecules secreted by adipose tissue ameliorate the capability to counteract oxidative stress by a physiological stimulation of intracellular antioxidant enzymes and positively impact on cell proliferation. Due to the presence of Wnt‐secreted factors, AT‐Ex treatment promotes glycogen synthase kinase 3β inactivation and consequently Wnt/β‐catenin pathway activation. Collectively, our findings show that AT‐Ex could be useful as a natural approach to improve treatment of vitiligo.

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Section: Discussionmentioning

confidence: 99%

Extracellular fraction of adipose tissue as an innovative regenerative approach for vitiligo treatment

Bellei

Papaccio

Filoni

et al. 2019

Experimental Dermatology

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“…However, the loss of melanocytes from vitiligo lesions is no longer considered complete, as several studies revealed the presence of some differentiated melanocytes in depigmented skin . It is unclear whether these sparse melanocytes have returned to the epidermis after the original injury, or whether a small population of intralesional cells remains . In the latter case, the physiology of such resilient melanocytes might inform us of intrinsic defense mechanisms that can prevent vitiligo.…”

Section: Melanocyte Lossmentioning

confidence: 99%

The convergence theory for vitiligo: A reappraisal

Kundu

Mhlaba

Rangel

et al. 2018

Experimental Dermatology

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Vitiligo is characterized by progressive loss of skin pigmentation. The search for aetiologic factors has led to the biochemical, the neurologic and the autoimmune theory. The convergence theory was then proposed several years ago to incorporate existing theories of vitiligo development into a single overview of vitiligo aetiology. The viewpoint that vitiligo is not caused only by predisposing mutations, or only by melanocytes responding to chemical/radiation exposure, or only by hyperreactive T cells, but rather results from a combination of aetiologic factors that impact melanocyte viability, has certainly stood the test of time. New findings have since informed the description of progressive depigmentation. Understanding the relative importance of such aetiologic factors combined with a careful selection of the most targetable pathways will continue to drive the next phase in vitiligo research: the development of effective therapeutics. In that arena, it is likewise important to acknowledge that pathways affected in some patients may not be altered in others. Taken together, the convergence theory continues to provide a comprehensive viewpoint of vitiligo aetiology. The theory serves to intertwine aetiologic pathways and will help to define pathways amenable to disease intervention in individual patients.

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“…At present, it is believed that mature or activated melanocytes in the basal layer of epidermis released melanin granules by exocytosis, transformed to keratinocytes and migrated into stratum corneum (Vie et al, 2009;Anbar et al, 2012). During the migratory process of melanin into stratum corneum, a number of keratinocytes may control the type of melanin globule receptor so that skins accordingly show various colors (Valyi-Nagy et al, 1990;Minwalla et al, 2001).…”

Section: The Regulation Of Melanin Synthesis Of Taihe Silky Fowlmentioning

confidence: 99%

Distribution rule of melanocytes in Taihe Silky Fowl’s black skin

Li¹,

Guo²,

Zhong³

et al. 2016

IJAR

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The aim was to investigate distribution characteristics of melanocytes in Taihe Silky Fowl's skin by Lillie's and DOPA staining methods and transmission electron microscopy. According to the present results, mature melanocytes were mainly located in basal layer of epidermis and hair follicle bulbs, whereas the amelanotic melanocytes were in the outer root sheath of hair follicles. In various partial skins, maturity levels of melanocytes generally were as: claw skin>rear skin>dorsal skin>abdominal skin>wattle skin>cockscomb skin. In mature melanocytes, melanosomes were divided into stage I, II, III and IV, and mostly belonged to stage IV. To conclude, melanocytes in hairy skin more easily reached mature status than in meaty skin and the melanocytes in dorsal skin matured faster than in abdominal skin as well. Furthermore, the melanin migration was subjected to the strict control of melanocytes, but had nothing to do with keratinocytes.

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Effect of PUVA therapy on melanocytes and keratinocytes in non‐segmental vitiligo: histopathological, immuno‐histochemical and ultrastructural study

Cited by 30 publications

References 14 publications

Extracellular fraction of adipose tissue as an innovative regenerative approach for vitiligo treatment

Extracellular fraction of adipose tissue as an innovative regenerative approach for vitiligo treatment

The convergence theory for vitiligo: A reappraisal

Distribution rule of melanocytes in Taihe Silky Fowl’s black skin

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