Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trial

Modabbernia, Amirhossein; Sohrabi, Hamid R.; Nasehi, Abbas-Ali; Raisi, Firoozeh; Saroukhani, Sepideh; Jamshidi, A H; Tabrizi, Mina; Ashrafi, Mandana; Akhondzadeh, Shahin

doi:10.1007/s00213-012-2729-6

Cited by 96 publications

(65 citation statements)

References 42 publications

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“…[65] Men and women treated with Selective Serotonin Reuptake Inhibitors (SSRIs) experienced beneficial effects on their sexual function by simultaneous administration of saffron extract. [111] Moreover, saffron seemed to ameliorate the sexual arousal, lubrication and pain domains of fluoxetinerelated sexual dysfunction in women. [112] However, there is no clear clinical evidence regarding neither the aphrodisiac effect of saffron nor its effectiveness on erectile dysfunction in males.…”

Section: Other Possible Applicationsmentioning

confidence: 99%

Saffron: a natural product with potential pharmaceutical applications

Christodoulou

Kadoglou

Kostomitsopoulos

et al. 2015

Journal of Pharmacy and Pharmacology

175

101

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Objectives Recently, a great deal of interest has been developed to isolate and investigate novel bioactive components from natural resources with health beneficial effects. Saffron is the dried stigma of Crocus sativus L. and has been used for centuries in traditional medicine mainly for its healing properties, as well as for the treatment of various pathological conditions. Objectives of the present review are to unravel its therapeutic properties and investigate the potential applications of saffron in contemporary therapy of a wide spectrum of diseases and summarize previous and current evidence regarding the biological/pharmacological activities of saffron and its active ingredients and their possible therapeutic uses. Key findings Recent phytochemistry and pharmacological experiments have indicated that crocin and safranal, the major active ingredients of saffron, exert important actions, such as antioxidant, anti-tumor, anti-diabetic, anti-inflammatory and anti-atherosclerotic. Unfortunately, the vast majority of those data derive from in vitro studies, whereas a limited number of in vivo experiments support the aforementioned effects. In addition to studies with mechanistic implications, very few clinical trials provide preliminary evidence of saffron potentiality to alleviate depression and increase cognitive function in patients with Alzheimer's disease. Summary The history and structural features of saffron constituents are given in the first part of the review, followed by a comprehensive and critical presentation of the published preclinical and clinical studies and review papers on the pharmacology and possible therapeutic uses of saffron and its main active components crocin and safranal.

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Section: Other Possible Applicationsmentioning

confidence: 99%

Saffron: a natural product with potential pharmaceutical applications

Christodoulou

Kadoglou

Kostomitsopoulos

et al. 2015

Journal of Pharmacy and Pharmacology

175

101

View full text Add to dashboard Cite

show abstract

“…In Iranian's traditional medicine, ointments containing saffron are used to treat hot palpitation of heart [4]. Scientific studies have confirmed the validity of saffron extracts in the treatment of mild to moderate depression [5,6], and agent against erectile dysfunction [7], and as anti-arrhythmic agent and restorer of cardicac functions [8,9]. Other studies showed a role of saffron as a protector against age related macular degeneration [10,11], in reducing cognitive decline in patients with Alzheimer Disease [12,13], and as a source for potential anti-cancer agents [14,15,16].…”

Section: Introductionmentioning

confidence: 99%

Petals of Crocus sativus L. as a potential source of the antioxidants crocin and kaempferol

et al. 2015

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“…Saffron aqueous extract 30 mg daily for 12 weeks could prevent metabolic syndrome and increases in blood glucose in schizophrenia patients on olanzapine treatment [48]. Saffron 15 mg twice daily for 4 weeks could significantly improve fluoxetine-related sexual dysfunction among both female and male patients with major depressive disorder who were stabilized on fluoxetine [49, 50]. …”

Section: Resultsmentioning

confidence: 99%

Therapeutic Risk and Benefits of Concomitantly Using Herbal Medicines and Conventional Medicines: From the Perspectives of Evidence Based on Randomized Controlled Trials and Clinical Risk Management

Zhang

Chen

Zhu

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Despite increased awareness of the potential of herb-drug interactions (HDIs), the lack of rigorous clinical evidence regarding the significance provides a challenge for clinicians and consumers to make rational decisions about the safe combination of herbal and conventional medicines. This review addressed HDIs based on evidence from randomized controlled trials (RCTs). Literature was identified by performing a PubMed search till January 2017. Risk description and clinical risk management were described. Among 74 finally included RCTs, 17 RCTs (22.97%) simply addressed pharmacodynamic HDIs. Fifty-seven RCTs (77.03%) investigated pharmacokinetic HDIs and twenty-eight of them showed potential or actual clinical relevance. The extent of an HDI may be associated with the factors such as pharmacogenomics, dose of active ingredients in herbs, time course of interaction, characteristics of the object drugs (e.g., administration routes and pharmacokinetic profiles), modification of herbal prescription compositions, and coexistence of inducers and inhibitors. Clinical professionals should enhance risk management on HDIs such as increasing awareness of potential changes in therapeutic risk and benefits, inquiring patients about all currently used conventional medicines and herbal medicines and supplements, automatically detecting highly substantial significant HDI by computerized reminder system, selecting the alternatives, adjusting dose, reviewing the appropriateness of physician orders, educating patients to monitor for drug-interaction symptoms, and paying attention to follow-up visit and consultation.

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Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trial

Abstract: Saffron is a tolerable and efficacious treatment for fluoxetine-related erectile dysfunction.

Cited by 96 publications

References 42 publications

Saffron: a natural product with potential pharmaceutical applications

Saffron: a natural product with potential pharmaceutical applications

Petals of Crocus sativus L. as a potential source of the antioxidants crocin and kaempferol

Therapeutic Risk and Benefits of Concomitantly Using Herbal Medicines and Conventional Medicines: From the Perspectives of Evidence Based on Randomized Controlled Trials and Clinical Risk Management

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