Effect of S-allylcysteine, a sulphur containing amino acid on iron metabolism in streptozotocin induced diabetic rats

Saravanan, G.; Ponmurugan, P.; Begum, Mustapha Shabana

doi:10.1016/j.jtemb.2012.07.009

Cited by 12 publications

(9 citation statements)

References 37 publications

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“…To further explore the underlying mechanisms of iron metabolism disorder in T2DM, we demonstrated iron metabolism disorder in STZ-induced diabetic rats fed with an HFD, as elucidated by the elevations in the serum ferritin and serum iron levels. These results concur with those of previous studies ( 22 , 23 , 24 ). Saravanan et al ( 23 ) showed that serum iron was increased in STZ rats, and Dogukan et al ( 17 ) reported that STZ injection following HFD intake markedly increased hepatic and serum iron levels.…”

Section: Discussionsupporting

confidence: 94%

“…These results concur with those of previous studies. [22][23][24] Saravanan et al [23] showed that serum iron was increased in STZ rats, and Dogukan et al [17] reported that STZ injection following HFD intake markedly increased hepatic and serum iron levels. There is little consensus on the underlying mechanisms of iron metabolism disorders in T2DM.…”

Section: Discussionmentioning

confidence: 99%

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Serum ferritin as a risk factor for type 2 diabetes mellitus, regulated by liver transferrin receptor 2

Zhang

Huang

et al. 2021

Endocrine Connections

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Objective The aim of this study was to evaluate the effect of TFR2 on iron storage in type 2 diabetes. Methods A cross-sectional study was conducted among 1938 participants from the Jiangchuan Community of Shanghai. A total of 784 participants with T2DM and 1154 normal participants (non-T2DM) were enrolled in this study. Serum ferritin, fasting blood glucose, postprandial blood glucose, and HbA1C (glycated hemoglobin A1c) levels were determined. Eighteen Wistar male rats were randomly assigned into three groups (n = 6/group): rats in a high-fat diet streptozotocin (HFD+STZ) group were fed with HFD for 4 weeks and intraperitoneally injected with streptozotocin (STZ); rats in a control group were fed with a standard diet for 4 weeks and intraperitoneally injected with buffer; rats in an STZ group were fed with a standard diet for 4 weeks and intraperitoneally injected with streptozotocin. Glucose tolerance test was performed at the end of the study. Blood samples and liver tissues were assessed for liver TFR2, blood glucose, serum ferritin, and iron levels. Results The mean serum ferritin level of T2DM participants was significantly higher than that of the control group (227 (140–352) vs 203.5 (130.5–312) ng/mL, P < 0.05). Serum ferritin level was an independent risk factor for T2DM (high ferritin group vs low ferritin group, 1.304 (1.03–1.651), P < 0.05). Diabetic rats showed reduced liver TFR2 levels, with increased serum ferritin levels. Conclusion T2DM participants exhibited iron disorder with elevated serum ferritin levels. Elevated serum ferritin levels in diabetic rats were accompanied by reduced liver TFR2 levels.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Serum ferritin as a risk factor for type 2 diabetes mellitus, regulated by liver transferrin receptor 2

Zhang

Huang

et al. 2021

Endocrine Connections

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“…STZ-induced elevation of iron storage was also observed in the proximal tubular lysosomes (27), myocardium (28), and artery (29), while studies of Silva et al (30) and Saravanan et al (31) showed that serum iron was increased in STZ rats. Additionally, Dogukan et al (32) reported that STZ injection following HFD induction markedly increased the hepatic and serum iron levels.…”

Section: Discussionmentioning

confidence: 90%

Hepcidin Is Directly Regulated by Insulin and Plays an Important Role in Iron Overload in Streptozotocin-Induced Diabetic Rats

et al. 2014

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Iron overload is frequently observed in type 2 diabetes mellitus (DM2), but the underlying mechanisms remain unclear. We hypothesize that hepcidin may be directly regulated by insulin and play an important role in iron overload in DM2. We therefore examined the hepatic iron content, serum iron parameters, intestinal iron absorption, and liver hepcidin expression in rats treated with streptozotocin (STZ), which was given alone or after insulin resistance induced by a high-fat diet. The direct effect of insulin on hepcidin and its molecular mechanisms were furthermore determined in vitro in HepG2 cells. STZ administration caused a significant reduction in liver hepcidin level and a marked increase in intestinal iron absorption and serum and hepatic iron content. Insulin obviously upregulated hepcidin expression in HepG2 cells and enhanced signal transducer and activator of transcription 3 protein synthesis and DNA binding activity. The effect of insulin on hepcidin disappeared when the signal transducer and activator of transcription 3 pathway was blocked and could be partially inhibited by U0126. In conclusion, the current study suggests that hepcidin can be directly regulated by insulin, and the suppressed liver hepcidin synthesis may be an important reason for the iron overload in DM2.

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“…Saravanan and colleagues have shown that oral administration of S -Allyl cysteine (SAC) treatment at 150 mg/kg bw for 45 days reduced fasting blood glucose (FBG) by 65%, ameliorated oxidative damages, glycosuria and improved the activities of glucose metabolizing enzymes in STZ-diabetic rats (Saravanan et al, 2009 , 2010 , 2013 ; Saravanan and Ponmurugan, 2010 , 2011 , 2012a , b ). Oral supplementation of SAC (0.5–1.0 g/l) for 4 or 10 weeks showed 34% more FBG reduction compared to n -acetyl cysteine, S -ethyl cysteine, S -methyl cysteine, and S -propyl cysteine (<30% FBG reduction) in STZ-induced Balb/cA mice (Hsu et al, 2004 ; Mong and Yin, 2012 ).…”

Section: Methodsmentioning

confidence: 99%

Spice-Derived Bioactive Ingredients: Potential Agents or Food Adjuvant in the Management of Diabetes Mellitus

Mohammed

Islam

2018

Front. Pharmacol.

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Spices possess tremendous therapeutic potential including hypoglycemic action, attributed to their bioactive ingredients. However, there is no study that critically reviewed the hypoglycemic potency, safety and the bioavailability of the spice-derived bioactive ingredients (SDBI). Therefore, the aim of the study was to comprehensively review all published studies regarding the hypoglycemic action of SDBI with the purpose to assess whether the ingredients are potential hypoglycemic agents or adjuvant. Factors considered were concentration/dosages used, the extent of blood glucose reduction, the IC50 values, and the safety concern of the SDBI. From the results, cinnamaldehyde, curcumin, diosgenin, thymoquinone (TQ), and trigonelline were showed the most promising effects and hold future potential as hypoglycemic agents. Conclusively, future studies should focus on improving the tissue and cellular bioavailability of the promising SDBI to achieve greater potency. Additionally, clinical trials and toxicity studies are with these SDBI are warranted.

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Effect of S-allylcysteine, a sulphur containing amino acid on iron metabolism in streptozotocin induced diabetic rats

Cited by 12 publications

References 37 publications

Serum ferritin as a risk factor for type 2 diabetes mellitus, regulated by liver transferrin receptor 2

Serum ferritin as a risk factor for type 2 diabetes mellitus, regulated by liver transferrin receptor 2

Hepcidin Is Directly Regulated by Insulin and Plays an Important Role in Iron Overload in Streptozotocin-Induced Diabetic Rats

Spice-Derived Bioactive Ingredients: Potential Agents or Food Adjuvant in the Management of Diabetes Mellitus

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