Effect of rosuvastatin on serum levels of vaspin and visfatin in patients with CAD

Werida, Rehab H.; Khedr, Lamiaa; El‐Sisi, Alaa E.; Salama, Mai

doi:10.4172/2368-0512.1000107

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…Also, the present study found a significant positive correlation between vaspin and D-dimer levels in all groups. Experiments also indicated that vaspin could inhibit the release of many inflammatory markers in vascular smooth muscle cells and reduce FFA-induced apoptosis in endothelial cells [39].…”

Section: Discussionmentioning

confidence: 97%

Serum Adropin and Vaspin Levels in Obese Rats with Polycystic Ovary Syndrome and After Metformin Treatment

Ashour

Abdel-Aleem

Khalil

et al. 2019

Zagazig University Medical Journal

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Background: Poly cystic ovary syndrome (PCOS) is the principal cause of anovulatory infertility.Adropin is a nutrient-regulated metabolic hormone shown to encourage glucose oxidation over fatty acid oxidation.Vaspin expression in visceral adipose tissue is associated with metabolic derangement in rat model of obesity and T2DM.Some studies addressed adropin and vaspin levels in PCOS, however, the results are controversial. Aim of the study: This study was designed to evaluate both serum adropin and vaspin levels in obese rats with PCOS and to detect any possible association of these levels with metabolic and hormonal changes in this condition with and without metformin treatment. Material and Methods: Twenty four female albino rats were divided into three equal groups. Group I:Control,Group II:obese rats with PCOS fed HFD for 9 weeks and given letrozole(1mg/kg BW)by gavage daily for the last 21 consecutive days.Group III:Metformin pretreated obese PCOS rats,at a dose of 200 mg/kgBWdaily along with letrozole for the last 21days.At the end of the experiment,Serum adropin,vaspin,sex hormones,insulin,glucose,lipid profile,TNF,plasma D-dimer and ovarian MDA levels were estimated.BMI, HOMA-IR were calculated.Ovarian histopathology was done. Results: Obese PCOS group showed significantly lower serum adropin and higher vaspin levels when compared to control group.Metformin pretreated group showed significantly higher serum adropin and lower vaspin levels when compared to obese PCOS group.Adropin was negatively correlated with all parameters except sex hormones.Vaspin was positively correlated with all parameters except sex hormones in all groups. Conclusion: Adropin and vaspin may represent a novel link between obesity and metabolic disturbance in obese PCOS rats.

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Section: Discussionmentioning

confidence: 97%

Serum Adropin and Vaspin Levels in Obese Rats with Polycystic Ovary Syndrome and After Metformin Treatment

Ashour

Abdel-Aleem

Khalil

et al. 2019

Zagazig University Medical Journal

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“…It has been reported that administration of atorvastatin, a lipophilic statin, decreases visfatin serum levels in Type II diabetic patients (Kadoglou et al 2012). In humans, serum visfatin levels have been decreased with the treatment of rosuvastatin in diabetic patients (Werida et al 2018). Both pravastatin and rosuvastatin decreased the visfatin level, but only pravastatin improved the fasting glucose level and body weight in our study.…”

Section: Discussionmentioning

confidence: 99%

The effect of hydrophilic statins on adiponectin, leptin, visfatin and vaspin levels in streptozocin-induced diabetic rats

Kaya,

Demirtas

2024

Preprint

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Statins may affect glucose metabolism through adipokines. The aim of this study was to measure the effects of hydrophilic statins on some adipokine levels in diabetic rats. Wistar albino rats were divided into four groups: healthy control, untreated diabetic, diabetic treated with pravastatin, and diabetic treated with rosuvastatin. Diabetes was induced by intraperitoneal injection of streptozotocin. Thereafter, 20 mg/kg/day doses of either pravastatin or rosuvastatin were administered to the treated diabetic rats for eight weeks. At the end of the experiment, the body weights, the levels of fasting blood glucose, serum insulin and insulin resistance as wel as serum adiponectin, leptin, visfatin and vaspin were measured. Fasting blood glucose and insulin resistance levels were significantly higher, whereas insulin level and the body weight were significantly lower in untreated diabetic group than the control group. Diabetes caused significant decreases in adiponectin, leptin, vaspin levels, but a significant increase in visfatin level. Pravastatin treatment significantly increased the body weight and decreased the fasting blood glucose level, whereas rosuvastatin decreased the body weight and did not have any effect on fasting blood glucose level. Pravastatin caused significant increases in both adiponectin and vaspin levels. However, rosuvastatin did not have any effect on adiponectin level, whereas caused a decrease in vaspin level. Both pravastatin and rosuvastatin treatments decreased the levels of leptin and visfatin. In conclussion, pravastatin is more effective to improve the fasting blood glucose level and the body weight in diabetes, probably by increasing adiponectin and vaspin levels.

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Effect of rosuvastatin on serum levels of vaspin and visfatin in patients with CAD

Cited by 2 publications

References 21 publications

Serum Adropin and Vaspin Levels in Obese Rats with Polycystic Ovary Syndrome and After Metformin Treatment

Serum Adropin and Vaspin Levels in Obese Rats with Polycystic Ovary Syndrome and After Metformin Treatment

The effect of hydrophilic statins on adiponectin, leptin, visfatin and vaspin levels in streptozocin-induced diabetic rats

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