Effect of rosmarinic acid on inhibition of gentamicin induced nephrotoxicity in rats

Beneficial Effects of Green Tea Extract in Gentamicin-Induced Acute Renal Failure in Rats / Povoljni efekti ekstrakta zelenog čaja na akutnu bubrežnu insuficijenciju uzrokovanu gentamicinom kod pacova

“…Our results showed decrease in serum creatinine and urea in group that was simultaneously treated with green tea, which indicates that administration of green tea ameliorates glomerular function (3). The biochemical analysis of our study was confirmed by the histopathological analysis, where GM group show necrosis of proximal tubules, vacuolization of cytoplasm and massive mononuclear inflammatory infiltrates in interstitium.…”

“…However, its use has been limited because of its adverse effect of causing nephrotoxicity (2). Gentamicin-induced nephrotoxicity is an animal model for study of acute kidney failure in experimental research (3). Although the mechanism by which gentamicin causes nephrotoxicity remains unclear, proposed pathological mechanisms include induction of oxidative stress, apoptosis, necrosis, elevation of endothelin I and increase of monocyte/macrophages infiltration (3)(4)(5).…”

“…Gentamicin-induced nephrotoxicity is an animal model for study of acute kidney failure in experimental research (3). Although the mechanism by which gentamicin causes nephrotoxicity remains unclear, proposed pathological mechanisms include induction of oxidative stress, apoptosis, necrosis, elevation of endothelin I and increase of monocyte/macrophages infiltration (3)(4)(5). Getamicininduced nephrotoxicity is clinically characterized by increased serum creatinine and blood urea nitrogen and decreased glomerular filtration rate (2,3) and morphologically by focal necrosis and apoptosis in tubular epithelium with extensive peritubular cell inflammation (2).…”

“…Getamicininduced nephrotoxicity is clinically characterized by increased serum creatinine and blood urea nitrogen and decreased glomerular filtration rate (2,3) and morphologically by focal necrosis and apoptosis in tubular epithelium with extensive peritubular cell inflammation (2). Gentamicin increases generation of reactive oxygen species (ROS), such as super oxide anions (6), hydroxyl radicals, hydrogen peroxide and reactive nitrogen species in the kidney (3).…”

Isolation, Quantification, and Identification of Rosmarinic Acid, Gas Chromatography-Mass Spectrometry Analysis of Essential Oil, Cytotoxic Effect, and Antimicrobial Investigation of Rosmarinus Officinalis Leaves.

“…Literature review revealed that rosmarinic acid and its derivatives have been shown to have biological activities, which included: antiinflammatory [8], anti hyperglycemic [9],anti allergic [10], anti bacterial activity [11], anti-oxidant [12], in addition those have beneficial effect in Parkinson's disease [13], neuroprotective effect [14], and also have nephroprotective activity belong to their antioxidant potency through enhancing the activity of antioxidant enzymes and enhancing the glutathione content [15]. R. officinalis contains a great quantity of essential oil that formed from chemical components; these are hydrocarbon monoterpenes (e.g., camphene, pinene, limonene, and myrcene), sesquiterpenes (e.g., caryophyllene), and oxygen deravatives such as alcohols (e.g., borneol, linalool, and terpineol), ketones (e.g., camphor and verbenone), oxide (e.g., 1, 8-cineole), esters (e.g., bornyl acetate), and others [16].…”