Effect of Resveratrol on Blood Lipid Levels in Patients with Type 2 Diabetes: A Systematic Review and Meta‐Analysis

Abstract

Objective: Few studies have considered the effect of resveratrol on blood lipid levels, and the results of these studies are inconsistent. In this study, the first meta-analysis on the effect of resveratrol on blood lipid levels in patients with type 2 diabetes was conducted. Methods: This study used keywords such as type 2 diabetes, total cholesterol, triglyceride (TG), high-density lipoprotein, low-density lipoprotein, and resveratrol and their abbreviations, free words, and related words to search PubMed, Cochrane Library, and Embase. The Cochrane risk of bias tool was used to evaluate the risk of bias, and Review Manager 5.3 and Stata 13.0 were used for data merging and statistical analysis. Results: Ten randomized controlled trials involving a total of 363 patients with type 2 diabetes were included in the analysis. The results show that longer resveratrol intervention time (≥6 months) can reduce TG levels. But resveratrol increased total cholesterol in patients within obesity range. In type 2 diabetes patients with obesity and in those who took lipid-lowering drugs, resveratrol increased low-density lipoprotein levels. Conclusions: Resveratrol can improve TG in patients with type 2 diabetes.

Efficacy and Safety of Resveratrol in Type 1 Diabetes Patients: A Two-Month Preliminary Exploratory Trial

“…To address this unique clinical difficulty, frontline T2D drug metformin has been explored as an addition to insulin treatment in such T1D patients [39]. Preclinical data showed that resveratrol was efficacious in preventing metabolic syndrome related to high-fat feeding, including insulin resistance, which lead to the pursuance of randomized clinical trials in T2D patients [40,41]. Evidently, resveratrol is known to recover dysregulated glucose homeostasis, while decreasing insulin resistance in T2D patients as reported by a myriad of clinical trials.…”

The Effect of Resveratrol Supplementation on Cardio‐Metabolic Risk Factors in Patients with Type 2 Diabetes: A Randomized, Double‐Blind Controlled Trial

“…Also, previous studies reported that resveratrol mediates cholesterol clearance by raising hydroxycholesterol production through regulation of the expression of cytochrome P450 27‐hydroxylase enzyme (Bingham et al, ). HDL‐C formation was also stimulated by resveratrol through adjusting the expression of main cholesterol transporters (Zhao et al, ). In addition, studies reported that resveratrol contributes to preventing the conversion of LDL‐C to oxidized LDL (Liu, Chen, & Li, ).…”

Urinary Resveratrol Metabolites Output: Differential Associations with Cardiometabolic Markers and Liver Enzymes in House-Dwelling Subjects Featuring Metabolic Syndrome

“…While in our results, no differences were found in the HDL-c concentrations. The discrepancies between our results related to the lipid metabolism could be partly explained for the T2DM status attributable to the synergetic effects of anti-diabetic drug and resveratrol as well as lipid-lowering medication [ 28 ]. It is important to mention that incidence of T2DM in our population was lower compared to Zamora et al, reported [ 35 ].…”

“…The lack of commercially available glucuronide and sulfate resveratrol standards is still an issue that hampers advancements in the quantification of total resveratrol metabolite. The lipophilic nature of resveratrol could facilitate the entry into the surface of albumin and lipoprotein, and these properties could confer benefits on lipid profile, avoiding the oxidation of LDL [ 28 , 37 , 38 ]. A study found that resveratrol metabolites, including trans -/ cis -resveratrol-3- O -glucuronide, and cis -resveratrol-3- O -glucoside, as well as free trans -resveratrol, were incorporated into the LDL of human participants after intake of moderate red wine, which could suggest the cardioprotective role of resveratrol on atherogenic markers and oxidative stress [ 37 ].…”

“…NAFLD, most of the studies on resveratrol, and the mechanism of action have been developed in vitro and animal rodents, which used higher resveratrol concentrations, different cell lines, and animal models that often overlap [ 26 ]. The protective effects of resveratrol on NAFLD mainly include improvements in principal risk factors, such as blood glucose and insulin levels [ 27 ], lipid metabolism [ 28 ], and liver damage [ 29 ], but results have remained inconclusive. In this regard, knowledge of the underlying effects of resveratrol metabolites on liver markers and risk of NAFLD in individuals diagnosed with MetS is still needed.…”