Effect of Repeated Injection and Continuous Infusion of Omeprazole and Ranitidine on Intragastric Ph Over 72 Hours Figure 1

Netzer, Peter; Gaia, C.; Sandoz, M.; Huluk, Tomas; Gut, A.; Halter, F; Hüsler, Jürg; Inauen, W.

doi:10.1111/j.1572-0241.1999.857_y.x

Cited by 69 publications

(7 citation statements)

References 40 publications

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“…PPIs increase intragastric pH effectively and reduce rebleeding in patients with peptic ulcer bleeding; however, the optimal dose of PPI is unknown. With PPI use, intragastric pH increases >6.0 for 84–99% of the day, which is optimal for stability of clot and hemostasis [23]. In a recent study, Hung et al [17] reported that bolus PPI is more effective in preventing rebleeding than without treatment.…”

Section: Discussionmentioning

confidence: 99%

Intermittent versus Continuous Pantoprazole Infusion in Peptic Ulcer Bleeding: A Prospective Randomized Study

et al. 2008

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Background and Aim: Rebleeding has remained the most important determinant of poor prognosis in peptic ulcer bleeding. Gastric acid plays an important role in the pathogenesis of rebleeding. We aimed to compare the efficiency of intermittent and continuous pantoprazole infusion treatment on peptic ulcer rebleeding after endoscopic therapy. Materials and Method: In this prospective study, patients with active peptic ulcer bleeding or non-bleeding visible vessel were treated initially with endoscopic therapy. They were randomized to receive intermittent or continuous intravenous pantoprazole treatment. Rebleeding rate, duration of hospital stay, need for total blood transfusion and need for urgent surgery were compared among both groups. Results: Rebleeding rate (6.1 vs. 8.3%), duration of hospital stay (4.17 vs. 4.41), need for total blood transfusion (2.18 vs. 2.59) and need for urgent surgery (4.1 vs. 4.2%) were similar in intermittent and continuous pantoprazole infusion therapy groups, respectively. There was no bleeding-related death in either group. Conclusion: In patients with peptic ulcer bleeding, intermittent and continuous pantoprazole infusion after successful endoscopic therapy have comparable outcomes in reducing rebleeding. Both have similar effects on hospital stay, need for blood transfusion and urgent surgery. Intermittent administration has application and cost advantages over continuous infusion.

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Section: Discussionmentioning

confidence: 99%

Intermittent versus Continuous Pantoprazole Infusion in Peptic Ulcer Bleeding: A Prospective Randomized Study

et al. 2008

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“…For example, an infusion of omeprazole (Prilosec) can keep the gastric pH above 6 for 72 hours without inducing tachyphylaxis. 20,21 Started after endoscopy. Randomized controlled trials have found proton pump inhibitors to be effective when given in high doses intravenously for 72 hours after successful endoscopic treatment of bleeding ulcers with high-risk endoscopic signs, such as active bleeding or nonbleeding visible vessels.…”

Section: Proton Pump Inhibitorsmentioning

confidence: 99%

Managing acute upper GI bleeding, preventing recurrences

Albeldawi

Qadeer

Vargo

2010

CCJM

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Acute upper gastrointestinal (GI) bleeding is common and potentially life-threatening and needs a prompt assessment and aggressive medical management. All patients need to undergo endoscopy to diagnose, assess, and possibly treat any underlying lesion. In addition, patients found to have bleeding ulcers should receive a proton pump inhibitor, the dosage and duration of treatment depending on the endoscopic findings and clinical factors.

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“…This attenuation of antisecretory activity has also been documented for other H 2 -receptor antagonists. 3,23) Netzer et al reported that tolerance to the antisecretory activity of ranitidine develops during infusion for 72-h periods leading to a loss of pH control. 3) In addition, Komazawa et al reported that tolerance occurs during 14 d of continuous famotidine administration.…”

Section: Resultsmentioning

confidence: 99%

“…3,23) Netzer et al reported that tolerance to the antisecretory activity of ranitidine develops during infusion for 72-h periods leading to a loss of pH control. 3) In addition, Komazawa et al reported that tolerance occurs during 14 d of continuous famotidine administration. 23) In the present study, 16 subjects (8 PMs, 7 heteroEMs, and 1 homoEM) also received 30 mg lansoprazole repetitively for 5 d, and 24-h intragastric pH monitoring was performed on day 1 and day 5.…”

Section: Resultsmentioning

confidence: 99%

Population Pharmacokinetics and Proton Pump Inhibitory Effects of Intravenous Lansoprazole in Healthy Japanese Males

Sakurai

Hirayama

Hashimoto

et al. 2007

Biological & Pharmaceutical Bulletin

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A total of 56 healthy Japanese males were enrolled in single- or multiple- dose pharmacokinetic trials of intravenous lansoprazole administration. The population pharmacokinetics of the drug was evaluated using nonlinear mixed effects model (NONMEM) software. In addition, the effect of CYP2C19 polymorphism on proton pump inhibition by lansoprazole was investigated using 24-h intragastric pH monitoring in the 32 subjects. Time course of serum lansoprazole concentration following intravenous short infusion was well described by a 2-compartment model. The mean volume of the central and peripheral compartments was 0.110 and 0.201 l/kg, respectively. The mean inter-compartment clearance was estimated to be 0.0882 l/h/kg. The population mean value of systemic clearance in the homoEM (CYP2C19 1/ 1), heteroEM (CYP2C19 1/2 and 1/3), and PM (CYP2C19 2/2, 2/3, and 3/3) groups was 0.179, 0.109, and 0.038 l/h/kg, respectively. The mean intragastric pH following twice-daily doses of 30 mg lansoprazole was approximately 6, 5, and 4 in the PM, heteroEM, and homoEM groups, respectively. These findings indicate that large interindividual variability exists in the pharmacokinetics of intravenously administered lansoprazole, but that twice-daily infusion of a 30 mg dose leads to significant and sustained proton pump inhibition, even in the homoEM group, despite the short elimination half-life of the drug.

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Effect of Repeated Injection and Continuous Infusion of Omeprazole and Ranitidine on Intragastric Ph Over 72 Hours Figure 1

Cited by 69 publications

References 40 publications

Intermittent versus Continuous Pantoprazole Infusion in Peptic Ulcer Bleeding: A Prospective Randomized Study

Intermittent versus Continuous Pantoprazole Infusion in Peptic Ulcer Bleeding: A Prospective Randomized Study

Managing acute upper GI bleeding, preventing recurrences

Population Pharmacokinetics and Proton Pump Inhibitory Effects of Intravenous Lansoprazole in Healthy Japanese Males

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