Effect of Regular Physical Training on Hemopoiesis in Experimental Animals

Kudaeva, O. T.; Колесникова, О. П.; Sukhenko, T. G.; Va, Kozlov

doi:10.1007/s10517-012-1680-1

Cited by 2 publications

(6 citation statements)

References 9 publications

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“…Increased levels of estrogen and IL-6 during physical activity can lead to the polyclonal activation of B-lymphocytes, which can be confirmed by the appearance of plasma cells in the peripheral blood of mice [18]. This increase in the number of lymphocytes and plasma cells was also observed in the present study.…”

Section: Discussionsupporting

confidence: 89%

“…This effect depends on the type, duration, and intensity of loads and immune parameters studied. In many cases, the suppression of immune processes was also observed [18]. Average number of neutrophils, macrophages, lymphocytes, and plasmocytes in the CG and EG after 2, 7, 14, and 21 Macrophages play an important role in the lesion repair process, as they are capable of promoting angiogenesis and tissue repair.…”

Section: Discussionmentioning

confidence: 92%

“…The polyclonal activation of B cells can be observed, together with a reduction in the intensity of the immune response. Hence, the phenomenon of the polyclonal activation of B-lymphocytes during exercise may well be a cause of immunosuppression under these conditions [18]. It is possible that, if the animals form the present study had been evaluated over a longer period of time, this immunosuppression may well have been detected.…”

Section: Discussionmentioning

confidence: 94%

“…In this sense, the greater number of neutrophils verified after 7 days in the EG may have indirectly favored the greater deposition of type III collagen after 14 days, considering that, since these cells were identified in a smaller quantity, possibly a lesser quantity of enzymes were also released, in turn promoting a lesser breakdown of the tissues, favoring progress in the lesion repair process. Kudaeva et al (2012) [18] observed that regular physical activity (swimming) of moderate intensity over a long period promotes a decrease of granulocytes in the peripheral blood. These authors postulate that the reduced relative content of granulocytes in the peripheral blood can be associated with the development of inflammation in muscle tissue, which is characteristic of active working muscles, the migration of granulocytic cells towards the site of inflammation, and their rapid death in these areas.…”

Section: Discussionmentioning

confidence: 99%

“…Godbout et al (2006) [19] also reported an increase in the number of macrophages in an acute injury of the tendon after physical activity. Kudaeva et al (2012) [18] observed that regular physical activity (swimming) of moderate intensity over a long period promotes an increase in the relative number of lymphocytes Fig. (1).…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Effect of Physical Activity on the Lesion Repair Process in the Gastrocnemius Muscle of Rats

Namba¹,

Nawick²,

Thome

et al. 2014

TOINFJ

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Abstract:The present study aimed to evaluate the effect of a progressive load of physical activity on a musculoskeletal injury in rats. Sixty-four rates were divided into two groups: experimental group (EG), which underwent physical activity (swimming) with a progressive load, and the control group (CG), which was not submitted to this program. The training was carried out according to an adapted version of the Gonçalves (1999) swimming system. Injuries were caused to the gastrocnemic muscle by inducing 40% NaOH. On days 2, 7, 14, and 21 after inducing muscle injury, the animals from both EC and CG were sacrificed. The injured area was removed and processed. The neutrophils, macrophages, lymphocytes, and plasmocytes were quantified by hematoxylin and eosin (H&E) stain. The percentage of the area of type I and type III collagen were quantified by a histological cut stained with picrosirius red stain (PSR) and submitted to polarization. A greater number of macrophages (GE=19.98±4.39; GC=2.48±1.00; p=0.006) and lymphocytes (GE=2.12±0.82; GC=0.06±0.82; p=0.037) after 2 days, and of macrophages (GE=15.74±3.00; GC=6.02±1.95; p=0.007) and lymphocytes (GE=2.01±0.78; GC=0.14±0.09; p=0.044) after 7 days, could be observed in the EG when compared to the CG; however, the opposite was true for neutrophils (GE=48.12±17.04; GC=105.54±12.25; p=0.005). After 14 days, a smaller quantity of neutrophils (GE= 32.70±10.26; GC= 90.96±17.62; p= 0.044) and a larger quantity of plasmocytes (GE=9.06±3.84; GC=0.68±0.53; p=0.028) could be observed in the EG as compared to the CG. A greater area of type III collagen could be observed in the EG when compared to the CG over a 14-day period (GE=44.90±16.15; GC=0.74±0.40; p=0.000) and a 21-day period (GE=13.19±9.09; GC=1.02±0.94; p=0.029), whereas the opposite could be observed for type I collagen. The physical activity promoted an increase in the deposition of type III collagen in the muscle injury. This activity accelerated the repair process after 14 days, possibly moderated by the larger number of inflammatory cells, while after 21 days, the lesion presented a lesser resistance.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Effect of Physical Activity on the Lesion Repair Process in the Gastrocnemius Muscle of Rats

Namba¹,

Nawick²,

Thome

et al. 2014

TOINFJ

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Influence of excessive exercise on immunity, metabolism, and gut microbial diversity in an overtraining mice model

Yuan

Huang

et al. 2018

Scandinavian Med Sci Sports

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The purpose of this study was to evaluate the negative influence of excessive exercise on immunity, substance and energy metabolism as well as gut microbiota in mice. Firstly, an overtraining model of Male Kunming mice was established by high-intensity swimming exercise for 4 weeks. Then, a series of evaluation indicators, including the routine blood analysis, immune organ coefficient, digestive enzymes, and aquaporins expression levels of small intestine and colon tissue, histological examinations of liver, spleen, small intestine, and colon, were determined based on this model. Furthermore, 16S rRNA gene sequencing was also employed to measure the microbial composition in gut. The results found that immune parameters, substance and energy metabolism of all mice was altered and disturbed after high-intensity swimming for 4 weeks, led to an atrophy of thymus and spleen as well as abnormal structural changes in liver when compared to non-swimming mice. Besides, excessive swimming mice had lower microbial diversity compared to non-swimming mice. However, there was no significant difference in gut microbial taxa between the two groups. The data indicated that excessive exercise exhibits negative impacts on immunity, substance and energy metabolism as well as gut microbial diversity.

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Effect of Regular Physical Training on Hemopoiesis in Experimental Animals

Cited by 2 publications

References 9 publications

Effect of Physical Activity on the Lesion Repair Process in the Gastrocnemius Muscle of Rats

Effect of Physical Activity on the Lesion Repair Process in the Gastrocnemius Muscle of Rats

Influence of excessive exercise on immunity, metabolism, and gut microbial diversity in an overtraining mice model

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