volume 66, issue 9, P5553-5560 1992
DOI: 10.1128/jvi.66.9.5553-5560.1992
View full text
F Lori, L Hall, P Lusso, M Popovic, P Markham, G Franchini, M S Reitz

Abstract: Human immunodeficiency virus type 1 (HIV-1) displays both interstrain and intrastrain genetic variability. Virus populations with extensive microheterogeneity have been defined as swarms or quasispecies. Many of the genomes within HIV-1 swarms appear to be defective in one or more genes required for viral replication. It is unclear to what extent defective viruses play a role in the process of HIV-1 infection or in the pathogenesis of AIDS. We have isolated two biologically active HIV-1 clones: LW 12.3, which …

expand abstract