Effect of Quinacrine (Atabrine) upon Lupus Erythematosus Phenomenon

Dubois, Edmund L.

doi:10.1001/archderm.1955.01540290010002

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1956

2021

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Cited by 21 publications

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“…This bond stabilizes DNA, inhibiting heat denaturation, enzymatic depolymerization, RNA transcription, and translation. Dubois (39) documented that the binding of QE to nucleoproteins can block the LE cell factor.…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

Antimalarials

VanBeek

Piette

2001

Dermatol Ther

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Over the last century, antimalarial medications have become the parenteral drugs of choice for treating the cutaneous manifestations of lupus erythematosus. The effects of immune modulation with the concomitant preservation of host immune response to exogenous antigens procures these agents as powerful tools in a wide range of conditions. With prudent dosage and monitoring, antimalarials can be used safely and effectively in the treatment and management of autoimmune connective tissue disease.

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Section: Mechanisms Of Actionmentioning

confidence: 99%

Antimalarials

VanBeek

Piette

2001

Dermatol Ther

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“…From this era, when corticosteroids were just being introduced, there are dozens of reports of the efficacy of quinacrine for discoid and systemic lupus [4–7]. Dubois described highly favorable responses to quinacrine [8] and interestingly reported that quinacrine impaired the formation of LE cells in vitro [9]. Frances Page in 1951 wrote that ‘Quinacrine …was used in a case of lupus erythematosus.…”

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confidence: 99%