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Cited by 112 publications
(82 citation statements)
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“…Over the past decades, methods have differed as to the beginning of administration of corticosteroids: (i) from the first hours of life (early), 6,[7][8][9]16,[45][46][47] (ii) from 7 to 14 days of life (moderately early), 12,23,48 (iii) after 14 days of life (late) 10,13,49,50 . Doses and the length of treatment (from 9 to 42 days) are also reported.…”
Section: Discussionmentioning
confidence: 99%
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“…Over the past decades, methods have differed as to the beginning of administration of corticosteroids: (i) from the first hours of life (early), 6,[7][8][9]16,[45][46][47] (ii) from 7 to 14 days of life (moderately early), 12,23,48 (iii) after 14 days of life (late) 10,13,49,50 . Doses and the length of treatment (from 9 to 42 days) are also reported.…”
Section: Discussionmentioning
confidence: 99%
“…Several clinical trials have described favorable effects with the use of corticosteroids in the neonatal period, including a reduction of the incidence of BPD, [5][6][7][8][9] the duration of mechanical ventilation, 6,10-13 and short-term improvement in pulmonary compliance.…”
mentioning
confidence: 99%
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“…Possible mechanisms of corticosteroid action include: stabilization of cell and lysosomal membranes 1 , increment of surfactant synthesis 2 , inhibition of prostaglandin and leukotriene synthesis 3 , decrease in polymorphonuclear cell recruitment to the lung 4,5 , enhancement of beta adrenergic activity 6 , reduction of pulmonary and bronchial interstitial fluid 7 . Several randomized clinical trials of postnatal corticosteroids in premature infants with bronchopulmonary dysplasia have been performed [8][9][10][11][12][13][14][15][16][17][18][19][20][21] . Despite a variety of study designs, some studies report that corticosteroids improve pulmonary compliance and facilitate extubation 10,11,15,18 , reduce the use of mechanical ventilation [8][9][10][11][12][13][14][15][16][17] and the length of oxygen therapy 11,13,14,16,19 .…”
mentioning
confidence: 99%
“…Several randomized clinical trials of postnatal corticosteroids in premature infants with bronchopulmonary dysplasia have been performed [8][9][10][11][12][13][14][15][16][17][18][19][20][21] . Despite a variety of study designs, some studies report that corticosteroids improve pulmonary compliance and facilitate extubation 10,11,15,18 , reduce the use of mechanical ventilation [8][9][10][11][12][13][14][15][16][17] and the length of oxygen therapy 11,13,14,16,19 . Besides other adverse effects, reduced growth 13,15,17 has been described as a consequence of corticosteroid treatment.…”
mentioning
confidence: 99%