Effect of procainamide on fibrillation threshold of normal and ischemic ventricles

Yoon, Myung S.; Han, Jaok; Goel, Brij G.; Creamer, Paula

doi:10.1016/0002-9149(74)90281-1

Cited by 28 publications

(3 citation statements)

References 9 publications

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“…4 Paradoxically, most antiarrhythmic medications increase the defibrillation threshold and, in theory, make defibrillation more difficult. [14][15][16][17][18][19] In a study involving historical controls, lidocaine appeared The New England Journal of Medicine to improve the success of resuscitation, 20 but it had no effect 21 or worsened the outcome 22,23 in other studies. Bretylium has been shown to be as effective as lidocaine, 24,25 but not necessarily better than placebo 26 for treating ventricular fibrillation.…”

Section: Discussionmentioning

confidence: 99%

Amiodarone for Resuscitation after Out-of-Hospital Cardiac Arrest Due to Ventricular Fibrillation

Kudenchuk,

Cobb,

Copass

et al. 1999

N Engl J Med

763

321

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Section: Discussionmentioning

confidence: 99%

Amiodarone for Resuscitation after Out-of-Hospital Cardiac Arrest Due to Ventricular Fibrillation

Kudenchuk,

Cobb,

Copass

et al. 1999

N Engl J Med

763

321

View full text Add to dashboard Cite

show abstract

“…4 Paradoxically, most antiarrhythmic medications increase the defibrillation threshold and, in theory, make defibrillation more difficult. [14][15][16][17][18][19] In a study involving historical controls, lidocaine appeared to improve the success of resuscitation, 20 but it had no effect 21 or worsened the outcome 22,23 in other studies. Bretylium has been shown to be as effective as lidocaine, 24,25 but not necessarily better than placebo 26 for treating ventricular fibrillation.…”

Section: Discussionmentioning

confidence: 97%

Amiodarone for Resuscitation After Out-ofHospital Cardiac Arrest Due to Ventricular Fibrillation

Pj¹,

La²,

Mk³

2000

Annals of Emergency Medicine

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“…But instead of complete time courses just single VFT data obtained at a constant time interval after repeated short-term coronary ligations performed on the same animal have been compared with each other (5,9,38,45,46,66,79,95). But instead of complete time courses just single VFT data obtained at a constant time interval after repeated short-term coronary ligations performed on the same animal have been compared with each other (5,9,38,45,46,66,79,95).…”

Section: Discussionmentioning

confidence: 99%

Changes in ventricular fibrillation threshold during repeated short-term coronary occlusion and release

et al. 1977

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The time course of changes in VFT was determined during the 1st phase of arrhythmia following coronary occlusion and during consecutive reperfusion in five repeated periods of occlusion and reperfusion in 10 mongrel dogs (17--24 kg). VFT was determined using a square wave pulse series of 140 ms duration which was triggered by the R-wave of the ECG and placed into the vulnerable period of the cardiac cycle. After acute occlusion VFT decreased to a minimum level within a few minutes and then increased again slowly up to the control value which was reached about 20 min after the ligation. When the occlusions were repeated several times the extent of the decrease in VFT became increasingly less and its duration increasingly shorter until finally there was no significant decrease in VFT. Reperfusion after coronary occlusion led to an abrupt decrease in VFT within 1 min, followed by a rapid increase to the control value. This time course did not depend upon the number of prior occlusions. The results show that in the case of repeating short-term coronary occlusions one cannot expect comparable VFT time courses for the consecutive periods of occlusion except for the 1st and 2nd ones. Differing mechanisms leading to the occurrence of VF after coronary ligation and during reperfusion are discussed.

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Effect of procainamide on fibrillation threshold of normal and ischemic ventricles

Cited by 28 publications

References 9 publications

Amiodarone for Resuscitation after Out-of-Hospital Cardiac Arrest Due to Ventricular Fibrillation

Amiodarone for Resuscitation after Out-of-Hospital Cardiac Arrest Due to Ventricular Fibrillation

Amiodarone for Resuscitation After Out-ofHospital Cardiac Arrest Due to Ventricular Fibrillation

Changes in ventricular fibrillation threshold during repeated short-term coronary occlusion and release

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