Effect of probiotics on the development of dimethylhydrazine-induced preneoplastic lesions in the mice colon

Abstract

ABSTRACT PURPOSE:To determine the effect of probiotics on the development of chemically induced (1, 2-dimethylhydrazine) colonic preneoplastic lesions, in mice. METHODS:The animals were divided into five groups. The control group was injected with carcinogen alone and the other groups also received probiotics (1-Lactobacillus delbrueckii UFV-H2b20; 2-Bifidobacterium animalis var. lactis Bb12; 3-L. delbrueckii UFVH2b20 plus B. animalis var. lactis Bb12; and 4-Saccharomyces boulardii) administered orally in dri…