Effect of Probiotic Supplementation on Intestinal Permeability in Overweight and Obesity: A Systematic Review of Randomized Controlled Trials and Animal Studies

DiMattia, Zachary; Damani, Janhavi J; Van Syoc, Emily; Rogers, Connie J

doi:10.1016/j.advnut.2023.100162

Cited by 3 publications

(2 citation statements)

References 109 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The GI tract safeguards the body from inflammatory stimuli from bacteria-derived compounds by mechanisms that include the tight junctions between epithelial cells, the intestinal alkaline phosphatase (IAP) produced by epithelial cells, the inner and outer mucus layers lining the lumen, and the anti-microbial proteins secreted from Paneth cells [8]. In both human studies and animal models, obesity is associated with compromised GI tract defense mechanisms as well as dysbiosis of the gut microbiota that together allow increased LPS passage into the liver and systemic circulation [29,30]. Macrophages are the most abundant immune cells in the liver and play a crucial role in regulating liver inflammation and immune response [31].…”

Section: Discussionmentioning

confidence: 99%

Soy Protein Concentrate Diets Inversely Affect LPS-Binding Protein Expression in Colon and Liver, Reduce Liver Inflammation, and Increase Fecal LPS Excretion in Obese Zucker Rats

Li,

Hakkak

2024

Nutrients

View full text Add to dashboard Cite

Dietary soy protein and soy isoflavones have anti-inflammatory properties. Previously, we reported that feeding soy protein concentrate diet (SPC) with low or high isoflavone (LIF or HIF) to young (seven-week-old) obese (fa/fa) Zucker rats inhibits lipopolysaccharide (LPS) translocation and decreases liver inflammation compared to a casein control (CAS) diet. The current study investigated whether SPC-LIF and SPC-HIF diets would reduce liver inflammation in adult obese Zucker rats fed a CAS diet. A total of 21 six-week-old male obese (fa/fa) Zucker rats were given CAS diet for 8 weeks to develop obesity then randomly assigned to CAS, SPC-LIF, or SPC-HIF (seven rats/group) diet for an additional 10 weeks. The expression of LPS-translocation, inflammation, and intestinal permeability markers were quantified by qPCR in liver, visceral adipose tissue (VAT), and colon. LPS concentration was determined in both the colon content and fecal samples by a Limulus amebocyte lysate (LAL) test. SPC-LIF and SPC-HIF diets significantly decreased liver LPS-binding protein (LBP) expression compared to CAS diet (p < 0.01 and p < 0.05, respectively). SPC-HIF diet also significantly decreased liver MCP-1 and TNF-α expression (p < 0.05) and had a trend to decrease liver iNOS expression (p = 0.06). In the colon, SPC-HIF diet significantly increased LBP expression compared to CAS diet (p < 0.05). When samples from all three groups were combined, there was a negative correlation between colon LBP expression and liver LBP expression (p = 0.046). SPC diets did not alter the expression of intestinal permeability markers (i.e., occludin, claudin 3, and zonula occludens-1) in the colon or inflammation markers (i.e., TNF-α and iNOS) in VAT or the colon. LPS levels in the colon content did not differ between any groups. Fecal LPS levels were significantly higher in the SPC-LIF and SPC-HIF groups compared to the CAS group (p < 0.01). In conclusion, SPC, particularly SPC with HIF, reduces liver LBP expression and inflammation makers (i.e., TNF-α and MCP-1 expression) in adult obese Zucker rats, likely by reducing LPS translocation.

show abstract

Section: Discussionmentioning

confidence: 99%

Soy Protein Concentrate Diets Inversely Affect LPS-Binding Protein Expression in Colon and Liver, Reduce Liver Inflammation, and Increase Fecal LPS Excretion in Obese Zucker Rats

Li,

Hakkak

2024

Nutrients

View full text Add to dashboard Cite

show abstract

“…In diseased states, this barrier can be impaired, resulting in increased intestinal permeability, allowing pathogenic microbial components such as LPS or even entire microbes into the systemic circulation, and causing inflammatory states and malabsorption. Increased intestinal permeability has been implicated in numerous disease states including autoimmune conditions such as systemic lupus erythematosus, cardiovascular disease, obesity, fatty liver disease, and inflammatory bowel disease, to name a few [ 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ]. While there are several mechanisms by which the intestinal barrier is regulated, the host microbiome and metabolome appear to be critically involved.…”

Section: Impact Of Prebiotics and Probiotics On Intestinal Permeabili...mentioning

confidence: 99%

Prebiotics and Probiotics for Gastrointestinal Disorders

Rau,

Gregg,

Yaceczko

et al. 2024

Nutrients

View full text Add to dashboard Cite

The complex role of the gut microbiome in the pathogenesis of gastrointestinal (GI) disorders is an emerging area of research, and there is considerable interest in understanding how diet can alter the composition and function of the microbiome. Prebiotics and probiotics have been shown to beneficially modulate the gut microbiome, which underlies their potential for benefit in GI conditions. Formulating specific recommendations for the public regarding these dietary supplements has been difficult due to the significant heterogeneity between strains, doses, and duration of treatment investigated across studies, as well as safety concerns with administering live organisms. This review aims to summarize the existing evidence for the use of prebiotics and probiotics in various GI disorders, paying special attention to strain-specific effects that emerged and any adverse effects noted.

show abstract

The effect of different sweeteners on the oral microbiome: a randomized clinical exploratory pilot study

Zakis,

Brandt,

van der Waal

et al. 2024

Journal of Oral Microbiology

View full text Add to dashboard Cite

Effect of Probiotic Supplementation on Intestinal Permeability in Overweight and Obesity: A Systematic Review of Randomized Controlled Trials and Animal Studies

Cited by 3 publications

References 109 publications

Soy Protein Concentrate Diets Inversely Affect LPS-Binding Protein Expression in Colon and Liver, Reduce Liver Inflammation, and Increase Fecal LPS Excretion in Obese Zucker Rats

Soy Protein Concentrate Diets Inversely Affect LPS-Binding Protein Expression in Colon and Liver, Reduce Liver Inflammation, and Increase Fecal LPS Excretion in Obese Zucker Rats

Prebiotics and Probiotics for Gastrointestinal Disorders

The effect of different sweeteners on the oral microbiome: a randomized clinical exploratory pilot study

Contact Info

Product

Resources

About