Effect of prenatal exposure to bisphenol a on the vagina of albino rats: immunohistochemical and ultrastructural study

Ahmed, Raeesa; ElGhamrawy, T. A.; Salama, Essam Eldin Abdelhady

doi:10.5603/fm.2014.0061

Cited by 7 publications

(4 citation statements)

References 42 publications

(48 reference statements)

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“…In general there was sever keratinization (hyper keratosis), epithelial atrophy and many cells completely degenerated, in addition to focal patches of decreasing of epithelial lining. These results came in harmony with study done by Ahmed et al (2014) who reported that exposure to BPA both in low environmental and high doses exerted degeneration of the vaginal epithelium with desquamation, hydropic degeneration and pyknosis. With high dose of BPA, there was extensive desquamation in addition to nearby areas of reactive thickening.…”

Section: Discussionsupporting

confidence: 90%

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Histopathological and Biochemical Study About the Chronic Administration of Bisphenol a on the Genital Tract of Adult Female Albino Rats

2021

Al-Azhar Medical Journal

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Background: Bisphenol A (BPA) is an industrial chemical synthesized by condensation of two phenol groups and one acetone molecule. Sources of exposure to bisphenol A including food especially canned food, dust, papers especially thermal because it comes with food or due to recycling with other types of paper, dental materials, medical devices and healthcare applications. In rodents and primates, as well as humans, orally administered bisphenol A is rapidly and efficiently (95% of dose) absorbed from the gastrointestinal tract and undergoes extensive first-pass metabolism in the gut wall and in the liver. During this first-pass metabolism, biotransformation of bisphenol A to bishenol Aglucuronide is the major pathway of BPA metabolism. Objective:To demonstrate the possible chronic toxic effect (biochemical & histopathological) of Bisphenol A on ovaries, uterus and vagina of adult female albino rats.

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Section: Discussionsupporting

confidence: 90%

“…BPA significantly downregulates their expression, leading to striking morphologic changes in the differentiation and cornification of vagina (Schönfelder et al 2010). Estrogen receptor α (ERα) down-regulation seems to be responsible for the observed altered vaginal morphology (Ahmed et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Histopathological and Biochemical Study About the Chronic Administration of Bisphenol a on the Genital Tract of Adult Female Albino Rats

2021

Al-Azhar Medical Journal

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“…Ahmed et al examined the morphological changes of the vagina after BPA exposure in rats, and the results showed that 0.1 mg/kg BPA treatment reduced the upper layer of the local vaginal plaque, whereas 50 mg/kg BPA directly caused the foamy cytoplasmic vacuolation and the pyknotic nuclei of the epithelial nucleus in the vagina, which might further lead to vaginal tumor lesions [ 293 ]. Both BPA and BPF exposure could alter the secretion function of vaginal epithelial cells in mice and lead to increased vaginal mucus [ 294 , 295 ].…”

Section: Toxic Effects Of Bisphenols On Other Female Reproductive Organsmentioning

confidence: 99%

Invisible Hand behind Female Reproductive Disorders: Bisphenols, Recent Evidence and Future Perspectives

Wu,

Tian,

Zhu

et al. 2023

Toxics

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Reproductive disorders are considered a global health problem influenced by physiological, genetic, environmental, and lifestyle factors. The increased exposure to bisphenols, a chemical used in large quantities for the production of polycarbonate plastics, has raised concerns regarding health risks in humans, particularly their endocrine-disrupting effects on female reproductive health. To provide a basis for future research on environmental interference and reproductive health, we reviewed relevant studies on the exposure patterns and levels of bisphenols in environmental matrices and humans (including susceptible populations such as pregnant women and children). In addition, we focused on in vivo, in vitro, and epidemiological studies evaluating the effects of bisphenols on the female reproductive system (the uterus, ovaries, fallopian tubes, and vagina). The results indicate that bisphenols cause structural and functional damage to the female reproductive system by interfering with hormones; activating receptors; inducing oxidative stress, DNA damage, and carcinogenesis; and triggering epigenetic changes, with the damaging effects being intergenerational. Epidemiological studies support the association between bisphenols and diseases such as cancer of the female reproductive system, reproductive dysfunction, and miscarriage, which may negatively affect the establishment and maintenance of pregnancy. Altogether, this review provides a reference for assessing the adverse effects of bisphenols on female reproductive health.

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“…Alterations in other reproductive tissues were also noted upon treatment with BPA. For example, prenatal BPA exposure in rhesus macaque altered the percentage of different cells in the fetal oviduct [27], and exposure of albino rats to BPA led to the degeneration of the vaginal epithelium [28]. In addition, CD1 mice treated with BPA exhibited uterine polyps and sarcoma of the uterine cervix [29].…”

Section: Introductionmentioning

confidence: 99%

Impact of Environmentally Relevant Concentrations of Bisphenol A (BPA) on the Gene Expression Profile in an In Vitro Model of the Normal Human Ovary

Zahra

Kerslake

Kyrou

et al. 2022

IJMS

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Endocrine-disrupting chemicals (EDCs), including the xenoestrogen Bisphenol A (BPA), can interfere with hormonal signalling. Despite increasing reports of adverse health effects associated with exposure to EDCs, there are limited data on the effect of BPA in normal human ovaries. In this paper, we present a detailed analysis of the transcriptomic landscape in normal Human Epithelial Ovarian Cells (HOSEpiC) treated with BPA (10 and 100 nM). Gene expression profiles were determined using high-throughput RNA sequencing, followed by functional analyses using bioinformatics tools. In total, 272 and 454 differentially expressed genes (DEGs) were identified in 10 and 100 nM BPA-treated HOSEpiCs, respectively, compared to untreated controls. Biological pathways included mRNA surveillance pathways, oocyte meiosis, cellular senescence, and transcriptional misregulation in cancer. BPA exposure has a considerable impact on 10 genes: ANAPC2, AURKA, CDK1, CCNA2, CCNB1, PLK1, BUB1, KIF22, PDE3B, and CCNB3, which are also associated with progesterone-mediated oocyte maturation pathways. Future studies should further explore the effects of BPA and its metabolites in the ovaries in health and disease, making use of validated in vitro and in vivo models to generate data that will address existing knowledge gaps in basic biology, hazard characterisation, and risk assessment associated with the use of xenoestrogens such as BPA.

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Effect of prenatal exposure to bisphenol a on the vagina of albino rats: immunohistochemical and ultrastructural study

Abstract: (Folia Morphol 2014; 73, 4: 399-408)

Cited by 7 publications

References 42 publications

Histopathological and Biochemical Study About the Chronic Administration of Bisphenol a on the Genital Tract of Adult Female Albino Rats

Histopathological and Biochemical Study About the Chronic Administration of Bisphenol a on the Genital Tract of Adult Female Albino Rats

Invisible Hand behind Female Reproductive Disorders: Bisphenols, Recent Evidence and Future Perspectives

Impact of Environmentally Relevant Concentrations of Bisphenol A (BPA) on the Gene Expression Profile in an In Vitro Model of the Normal Human Ovary

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