Effect of prednisolone on IgE-dependent biphasic cutaneous reaction in BALB/c mice

Inagaki, Nobuya; Tsunematsu, Miwako; Sakurai, Tosifumi; Matsuo, Akihiko; Nagai, Hiroichi

doi:10.1016/s0306-3623(96)00166-8

Cited by 14 publications

(25 citation statements)

References 21 publications

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“…The cutaneous reaction was evaluated 24 h after the cytokine injection. As the injection of saline into mouse ears does not increase ear thickness at 24 h [18, 19], a saline (cytokine-free) control was omitted in the present experiments. Results are shown in figure 4.…”

Section: Resultsmentioning

confidence: 99%

“…IgE-mediated biphasic cutaneous reactions were evoked in BALB/c mice as reported previously [16, 17, 18, 19]. Briefly, mice were passively sensitized by an intravenous injection of 1.0 ml monoclonal IgE preparation.…”

Section: Methodsmentioning

confidence: 99%

“…Data were expressed as the net increase in ear thickness by subtracting the value measured immediately before antigen application. A cutaneous reaction was also elicited by injecting 10 µl of SIN-1, IL-1β or TNF-α solution into the ear of mice [18, 19]. The reaction was assessed by measuring the ear thickness as mentioned above.…”

Section: Methodsmentioning

confidence: 99%

“…data]. We also indicated the participation of proinflammatory cytokines, such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α), especially in the late phase [18, 19]. These cytokines could cause ear edema directly, which may correspond to the late phase.…”

Section: Introductionmentioning

confidence: 99%

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Possible Role of Nitric Oxide in IgE-Mediated Allergic Cutaneous Reaction in Mice

Musoh

Nakamura²,

Ueda³

et al. 1997

Int Arch Allergy Immunol

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The role of nitric oxide (NO) in the development of allergic cutaneous reactions in mice was investigated. A biphasic cutaneous reaction composed of an immediate-phase edema and a late-phase edema was evoked by epicutaneous application of 2,4-dinitrofluorobenzene on the ear of mice passively sensitized with mouse anti-dinitrophenol monoclonal IgE. Two NO synthase inhibitors, L-N^G-nitroarginine methyl ester (L-NAME) and N^G-monomethyl-L-arginine, significantly inhibited both phases of the IgE-mediated biphasic cutaneous reaction. Simultaneous treatment with L-arginine attenuated the inhibitory effect of L-NAME. An NO donor, 3-morpholinosydononimine-N-ethylcarbamide, caused a potent edematous reaction in the mouse ear. Furthermore, L-NAME inhibited the cutaneous reactions caused by both interleukin-1β and tumor necrosis factor-α, putative mediators of the late-phase edema in the biphasic cutaneous reaction. These results indicate that a gaseous mediator, NO, participates, at least in part, in the development of ear edema in the IgE-mediated biphasic cutaneous reaction in mice.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Possible Role of Nitric Oxide in IgE-Mediated Allergic Cutaneous Reaction in Mice

Musoh

Nakamura²,

Ueda³

et al. 1997

Int Arch Allergy Immunol

Self Cite

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show abstract

“…In contrast, inflammatory cytokines such as tumor necrosis factor (TNF)-α and interleukin (IL)-1β seem to participate in the second phase response (15,16). TNF-α and IL-1β induce ear swelling similar to the second phase response, and antibodies against TNF-α and IL-1β clearly inhibit the second phase ear swelling.…”

Section: Triphasic Cutaneous Reaction In the Mouse Earmentioning

confidence: 99%

Analysis of the Mechanism for the Development of Allergic Skin Inflammation and the Application for Its Treatment: Mouse Models for the Development of Remedies for Human Allergic Dermatitis

Inagaki

Nagai

2009

J Pharmacol Sci

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Abstract. Animal models for human diseases are important for the elucidation of mechanisms involved in as well as for the establishment of effective treatment strategies for the diseases. Many mouse allergic dermatitis models have been established and applied for the development of remedies for human allergic dermatitis. One of the simplest allergic cutaneous reaction models is passive cutaneous anaphylaxis. Skin mast cells passively sensitized with antigen-specific IgE are activated upon antigen challenge to cause vascular permeability increase. The triphasic cutaneous reaction is another interesting model in which triphasic cutaneous swelling appears in mice passively sensitized with IgE upon challenge with specific antigen. Recently, many allergic dermatitis models have been established by repeated antigen exposure. Although the induced dermatitis seems to be complex, these models may possess the characteristic features observed in patients. Naturally occurring dermatitis model mice such as NC/Nga, NOA, and DS-Nh mice, and gene-knockout and transgenic mice exhibiting spontaneous dermatitis are also known. Establishment and characterization of the mouse dermatitis models seem to be important for understanding dermatitis and development of new strategies for the treatment of these diseases.

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Effect of Y-24180, an antagonist at platelet-activating factor (PAF) receptors, on IgE-mediated cutaneous reactions in mice

Yamaguchi¹,

Tomomatsu²,

Kagoshima³

et al. 1998

Inflammation Research

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Effect of prednisolone on IgE-dependent biphasic cutaneous reaction in BALB/c mice

Cited by 14 publications

References 21 publications

Possible Role of Nitric Oxide in IgE-Mediated Allergic Cutaneous Reaction in Mice

Possible Role of Nitric Oxide in IgE-Mediated Allergic Cutaneous Reaction in Mice

Analysis of the Mechanism for the Development of Allergic Skin Inflammation and the Application for Its Treatment: Mouse Models for the Development of Remedies for Human Allergic Dermatitis

Effect of Y-24180, an antagonist at platelet-activating factor (PAF) receptors, on IgE-mediated cutaneous reactions in mice

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