Effect of polymer viscosity on physicochemical properties and ocular tolerance of FB-loaded PLGA nanospheres

Araújo, Joana; Vega, E.; Lopes, Carla Martins; Egea, M.A.; García, María L.; Souto, Eliana B.

doi:10.1016/j.colsurfb.2009.03.028

Cited by 141 publications

(81 citation statements)

References 34 publications

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“…If the BS profiles have a deviation of ≤±2% it can be considered that there are no significant variations in particle size. Variations up to ±10% indicate unstable formulations (Araújo et al, 2009;Celia et al, 2009). From the results depicted in Fig.…”

Section: Resultsmentioning

confidence: 92%

“…TurbiscanLab ® is useful to detect destabilization phenomena much earlier and also in a simpler way than other methods, since it is based on the measurement of backscattering (BS) and transmission (T) signals (Araújo et al, 2009;Celia et al, 2009;Marianecci et al, 2010;Liu et al, 2011).…”

Section: Stability Analysis Of Ln By Turbiscanlab ®mentioning

confidence: 99%

“…The equipment is composed of a near-infrared light source ( = 880 nm), and 2 synchronous transmission (T) and backscattering (BS) detectors. The T detector receives the light crossing the sample, whereas the BS detector receives the light scattered backwards by the sample (Araújo et al, 2009). The detection head scans the entire height of the sample cell (20 mm longitude), acquiring T and BS each 40 m, 3 times during 10 min at different times after production (7, 15 and 30 days).…”

Section: Stability Analysis Of Ln By Turbiscanlab ®mentioning

confidence: 99%

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Design of cationic lipid nanoparticles for ocular delivery: Development, characterization and cytotoxicity

Fangueiro

Andreani

Egea

et al. 2014

International Journal of Pharmaceutics

129

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a b s t r a c tIn the present study we have developed lipid nanoparticle (LN) dispersions based on a multiple emulsion technique for encapsulation of hydrophilic drugs or/and proteins by a full factorial design. In order to increase ocular retention time and mucoadhesion by electrostatic attraction, a cationic lipid, namely cetyltrimethylammonium bromide (CTAB), was added in the lipid matrix of the optimal LN dispersion obtained from the factorial design. There are a limited number of studies reporting the ideal concentration of cationic agents in LN for drug delivery. This paper suggests that the choice of the concentration of a cationic agent is critical when formulating a safe and stable LN. CTAB was included in the lipid matrix of LN, testing four different concentrations (0.25%, 0.5%, 0.75%, or 1.0%wt) and how composition affects LN behavior regarding physical and chemical parameters, lipid crystallization and polymorphism, and stability of dispersion during storage. In order to develop a safe and compatible system for ocular delivery, CTAB-LN dispersions were exposed to Human retinoblastoma cell line Y-79. The toxicity testing of the CTAB-LN dispersions was a fundamental tool to find the best CTAB concentration for development of these cationic LN, which was found to be 0.5 wt% of CTAB.

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Section: Resultsmentioning

confidence: 92%

Section: Stability Analysis Of Ln By Turbiscanlab ®mentioning

confidence: 99%

Section: Stability Analysis Of Ln By Turbiscanlab ®mentioning

confidence: 99%

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Design of cationic lipid nanoparticles for ocular delivery: Development, characterization and cytotoxicity

Fangueiro

Andreani

Egea

et al. 2014

International Journal of Pharmaceutics

129

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“…Para um determinado volume da fase interna, o aumento da concentração do polímero aumenta a viscosidade dessa fase, obtendo-se nanosferas de maiores dimensões, devido à maior dificuldade de dispersão da fase interna na fase externa [25] .…”

Section: Concentração Do Polímerounclassified

“…Este método permite controlar melhor as dimensões das nanosferas, em comparação com o método que se baseia na emulsificação-evaporação do solvente, permitindo, por isso, reduzir o seu tamanho. As características fisico-químicas das nanosferas obtidas por deslocamento do solvente são afetadas por um conjunto de parâmetros tecnológicos, que incluem a solubilidade do princípio ativo, a natureza do solvente orgânico, a massa molar e a concentração do polímero, a concentração do tensoativo, a temperatura da fase externa, as dimensões do dispositivo e a velocidade de injeção da fase interna na fase externa [25,34] .…”

Section: Nanosferasunclassified

Preparação de nanopartículas poliméricas a partir de polímeros pré-formados: parte II

2012

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Nanopartículas poliméricas produzidas a partir de polímeros pré-formados, como os poliésteres alifáticos, têm sido amplamente utilizadas para incorporar, principalmente, princípios ativos lipofílicos. A produção das nanopartículas (nanocápsulas e nanosferas) por polímeros pré-formados pode ser realizada por emulsificação-evaporação do solvente, por deslocamento do solvente, por salting-out ou por emulsificação-difusão do solvente. Estes métodos de produção estão revisados e descritos neste artigo, evidenciando os parâmetros tecnológicos que interferem nas características físico-químicas das nanopartículas, como a solubilidade do princípio ativo, o volume e pH do meio de polimerização, a massa molar e concentração do monômero e a natureza e concentração do tensoativo.

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Poly Lactic‐Co‐Glycolic Acid (PLGA) Copolymer and Its Pharmaceutical Application

Pandey

Jain

2015

Handbook of Polymers for Pharmaceutical Technologies

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Effect of polymer viscosity on physicochemical properties and ocular tolerance of FB-loaded PLGA nanospheres

Cited by 141 publications

References 34 publications

Design of cationic lipid nanoparticles for ocular delivery: Development, characterization and cytotoxicity

Design of cationic lipid nanoparticles for ocular delivery: Development, characterization and cytotoxicity

Preparação de nanopartículas poliméricas a partir de polímeros pré-formados: parte II

Poly Lactic‐Co‐Glycolic Acid (PLGA) Copolymer and Its Pharmaceutical Application

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