volume 268, issue 1-2, P71-79 2003
DOI: 10.1016/j.ijpharm.2003.09.003
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Abstract: The objective of the work was to investigate the effects of a range of poly-hydroxy aliphatic esters (poly-lactide (PLA) and poly-lactide-co-glycolide (PLGA)) of different molecular weight and composition on the release and stability of the amphoteric drug amoxycillin. The effect of this amphoteric drug on the extent and kinetics of polymer degradation was also investigated. The polymers were used to prepare drug-free and drug-loaded cylindrical discs. Drug release profiles were determined while changes in pol…

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