Effect of platelet-rich plasma in alveolar distraction osteogenesis: a controlled clinical trial

Menezes, Diogo José Barreto de; Shibli, Jamil Awad; Gehrke, Sérgio Alexandre; Beder, Andréa M.; Sendyk, Wilson Roberto

doi:10.1016/j.bjoms.2015.09.027

Cited by 15 publications

(12 citation statements)

References 17 publications

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“…Among the different procedures that can be used to regenerate bone defects are guided bone regeneration (GBR) with membranes [9], the application of onlay/inlay bone blocks [10, 11], maxillary sinus augmentation [12], and the use of bone distraction [13] or the split-crest technique [14]. …”

Section: Introductionmentioning

confidence: 99%

“…Although all these surgical techniques can be successful in regenerating bone, the incidence of failures and problems that occur during these augmentation procedures is rather high [4, 5, 9–13]. In fact, these techniques are complex and require skill and experience from the operator; the operating time can be lengthy with major discomfort for the patient, and the risk of complications can be high [4–6, 9–13].…”

Section: Introductionmentioning

confidence: 99%

“…In fact, these techniques are complex and require skill and experience from the operator; the operating time can be lengthy with major discomfort for the patient, and the risk of complications can be high [4–6, 9–13]. …”

Section: Introductionmentioning

confidence: 99%

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Custom-Made Synthetic Scaffolds for Bone Reconstruction: A Retrospective, Multicenter Clinical Study on 15 Patients

Luongo¹,

Mangano

Macchi

et al. 2016

BioMed Research International

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Purpose. To present a computer-assisted-design/computer-assisted-manufacturing (CAD/CAM) technique for the design, fabrication, and clinical application of custom-made synthetic scaffolds, for alveolar ridge augmentation. Methods. The CAD/CAM procedure consisted of (1) virtual planning/design of the custom-made scaffold; (2) milling of the scaffold into the exact size/shape from a preformed synthetic bone block; (3) reconstructive surgery. The main clinical/radiographic outcomes were vertical/horizontal bone gain, any biological complication, and implant survival. Results. Fifteen patients were selected who had been treated with a custom-made synthetic scaffold for ridge augmentation. The scaffolds closely matched the shape of the defects: this reduced the operation time and contributed to good healing. A few patients experienced biological complications, such as pain/swelling (2/15: 13.3%) and exposure of the scaffold (3/15: 20.0%); one of these had infection and complete graft loss. In all other patients, 8 months after reconstruction, a well-integrated newly formed bone was clinically available, and the radiographic evaluation revealed a mean vertical and horizontal bone gain of 2.1 ± 0.9 mm and 3.0 ± 1.0 mm, respectively. Fourteen implants were placed and restored with single crowns. The implant survival rate was 100%. Conclusions. Although positive outcomes have been found with custom-made synthetic scaffolds in alveolar ridge augmentation, further studies are needed to validate this technique.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Custom-Made Synthetic Scaffolds for Bone Reconstruction: A Retrospective, Multicenter Clinical Study on 15 Patients

Luongo¹,

Mangano

Macchi

et al. 2016

BioMed Research International

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“…These techniques include onlay/inlay bone grafting [6, 7], distraction osteogenesis [8], maxillary sinus augmentation [9], inferior alveolar nerve transposition [10], alveolar ridge split [11], and guided bone regeneration (GBR) with resorbable [12] and nonresorbable membranes, such as those in polytetrafluoroethylene (PTFE) [13] or titanium [14]. …”

Section: Introductionmentioning

confidence: 99%

Alveolar Ridge Reconstruction with Titanium Meshes and Simultaneous Implant Placement: A Retrospective, Multicenter Clinical Study

Gomes¹,

Freixas²,

Han³

et al. 2016

BioMed Research International

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Objective. To evaluate horizontal bone gain and implant survival and complication rates in patients treated with titanium meshes placed simultaneously with dental implants and fixed over them. Methods. Twenty-five patients treated with 40 implants and simultaneous guided bone regeneration with titanium meshes (i–Gen®, MegaGen, Gyeongbuk, Republic of Korea) were selected for inclusion in the present retrospective multicenter study. Primary outcomes were horizontal bone gain and implant survival; secondary outcomes were biological and prosthetic complications. Results. After the removal of titanium meshes, the CBCT evaluation revealed a mean horizontal bone gain of 3.67 mm (±0.89). The most frequent complications were mild postoperative edema (12/25 patients: 48%) and discomfort after surgery (10/25 patients: 40%); these complications were resolved within one week. Titanium mesh exposure occurred in 6 patients (6/25 : 24%): one of these suffered partial loss of the graft and another experienced complete graft loss and implant failure. An implant survival rate of 97.5% (implant-based) and a peri-implant marginal bone loss of 0.43 mm (±0.15) were recorded after 1 year. Conclusions. The horizontal ridge reconstruction with titanium meshes placed simultaneously with dental implants achieved predictable satisfactory results. Prospective randomized controlled trials on a larger sample of patients are required to validate these positive outcomes.

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“…A systematic review of the effects of PRP concluded that it is of minimal benefit in sinus elevation but that it is of clear benefit in the treatment of periodontal defects (Plachokova et al). The effect of PRP in alveolar distraction osteogenesis was evaluated and its addition had a protective effect on the mucous membrane around the distractor, which decreased the potential for complications (Menezes et al, 2016). These favorable effects in soft tissue repair have been attributed to antimicrobial properties of PRP.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Effect of Platelet-Rich Plasma on Alveolar Wound Healing in Rats

et al. 2017

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SUMMARY:Opinions about the clinical utility of platelet-rich plasma (PRP) vary, as a large number of experimental studies have questioned its efficacy. The purpose of this study was to evaluate the effects of PRP on experimental alveolar wound healing in rats. Fifty young adult male Wistar rats were divided in control and PRP groups and submitted to extraction of the right maxillary incisor. In the PRP group, blood was collected by cardiac puncture, and the socket was filled with a PRP gel. Animals were euthanized after 1, 3, 7, 14 and 30 days. Histological and histomorphometric analyses were performed at each experimental time point. Semiquantitative histological analysis showed that the PRP group exhibited significantly more collagen-matrix deposition and less bone-matrix formation in the socket than did the control group from 7 to 30 days. Histomorphometric analyses showed that the PRP group also exhibited lower bonetissue areas than the control group at 7 (p=0.0250) and 14 days (p<0.0001), but at 30 days, no significant difference between the groups was observed. In the present study, PRP did not enhance alveolar wound healing, and PRP-treated rats exhibited low rates of bone deposition during the intermediate phases of alveolar socket repair.

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Effect of platelet-rich plasma in alveolar distraction osteogenesis: a controlled clinical trial

Cited by 15 publications

References 17 publications

Custom-Made Synthetic Scaffolds for Bone Reconstruction: A Retrospective, Multicenter Clinical Study on 15 Patients

Custom-Made Synthetic Scaffolds for Bone Reconstruction: A Retrospective, Multicenter Clinical Study on 15 Patients

Alveolar Ridge Reconstruction with Titanium Meshes and Simultaneous Implant Placement: A Retrospective, Multicenter Clinical Study

Evaluation of the Effect of Platelet-Rich Plasma on Alveolar Wound Healing in Rats

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