2021
DOI: 10.1186/s12967-021-02892-5
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Abstract: Background Until now, epidemiological evidence regarding the association between vitamin C intake (both diet and supplements) and Parkinson’s disease (PD) remains inconsistent. Hence, it is necessary to establish the causal link between vitamin C levels and PD, and further develop effective therapies or prevention. Methods We selected 11 newly identified plasma vitamin C genetic variants from a large-scale plasma vitamin C GWAS dataset (n = 52,018)… Show more

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Cited by 20 publications
(16 citation statements)
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“…Three principal assumptions were prerequisites in the MR study [ 24 , 25 ] and are described in Fig. 1 .…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Three principal assumptions were prerequisites in the MR study [ 24 , 25 ] and are described in Fig. 1 .…”
Section: Methodsmentioning
confidence: 99%
“…The TwoSampleMR R package was used to perform a two-sample MR study. One hundred and fifteen independent 25OHD genetic variants with each trait at p < 5 × 10 −8 are demonstrated in Additional file 1 : Table S1 and were selected as “suggestive” instruments in our MR studies, as described in recent studies [ 24 , 25 ]. To obtain a more accurate effect size estimate with these variants, the following rules was used to remove some variants.…”
Section: Methodsmentioning
confidence: 99%
“…In the two-sample MR study, three principal assumptions ( 11 , 12 ) were described in Figure 1 . Assumption 1 was that omega-3 fatty acid genetic instrument variants are reliably associated with the levels of plasma omega-3 fatty acids (exposure factor).…”
Section: Methodsmentioning
confidence: 99%
“…IVs should satisfy three major hypotheses (Figure 1), which have been widely described in recent studies (Liu et al, 2018;Liu et al, 2021).…”
Section: Introductionmentioning
confidence: 92%