Effect of “Pistacia atlantica” Resin (Baneh) on Functional Dyspepsia: A Double-Blind, Randomized Clinical Study

Eftekharafzali, Mahdiyehsadat; Mehrabani, Mitra; Tajadini, Haleh; Ahmadi, Bijan; Zahedi, Mohammad Javad

doi:10.5812/ircmj.63822

Cited by 7 publications

(11 citation statements)

References 29 publications

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“…Comparison of the Effect of Mastic, Coriander Triphala, and Omeprazole on the Improvement (%) of GERD-HRQL, Reflux Syndrome, FSSG, and VAS Another study byDabos et al (20) in patients with functional dyspepsia proved that Pistacia improved the symptoms compared to a placebo. Similar to what we concluded, Eftekharafzali et al(47) also showed that an eight-week treatment with Pistacia spp. reduced the GI symptoms such as pain and burning compared to the placebo group.…”

supporting

confidence: 91%

Effects of Pistacia lentiscus and Coriander Triphala on Adult Gastroesophageal Reflux Disease: A Randomized Double-Blinded Clinical Trial

Sadeghi

Fazljou

Sepehri

et al. 2020

Iran Red Crescent Med J

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Background: The cardinal symptoms of gastroesophageal reflux disease include heartburn (pyrosis) and regurgitation. Conventional treatment is done by proton pump inhibitors. In Persian traditional medicine, several herbs (single or combined) have been used to treat gastrointestinal disorders. Objectives: This study aimed to assess the effects of Pistacia lentiscus (mastic) and Coriander Triphala on reflux symptoms compared to omeprazole in a double-blinded randomized clinical trial. Methods: In a double-blinded, multicenter, randomized clinical trial, we assessed the effects of Pistacia lentiscus L., Coriander Triphala, and omeprazole on the symptoms of GERD in Tabriz, Iran, in 2018 - 2019. Thus, 105 patients with GERD symptoms were assigned randomly to three groups as group A (Pistacia lentiscus L., 1000 mg/TDS), group B (Coriander Triphala, 1000 mg/TDS), and group C (omeprazole, 20 mg/day plus five placebo capsules per day). The assessments were done at the beginning and the end of the study using FSSG, VAS, RS, and GERD-HRQL questionnaires. Results: In the beginning, no significant differences were observed between the groups in the background characteristics. There was no statistically significant difference between Pistacia lentiscus, Coriander Triphala, and omeprazole in the improvement of FSSG, VAS, GERD-HRQL, and reflux scores. In all groups, the FFSG, VAS, reflux, and GERD-HRQL scores significantly decreased and improved after four weeks of intervention compared to the respective baselines. The FSSG score improvements after four weeks of intervention were 73.68%, 83.33%, and 68.62%, in groups A, B, and C, respectively. The VAS score improvements were 66.66%, 75.00%, and 62.50% in groups A, B, and C, respectively. Improvements in GERD-HRQL were 90.00%, 91.28%, and 82.00%, in groups A, B, and C, respectively. Reflux improvements were 66.66%, 80.00%, and 66.66% in groups A, B, and C, respectively. Conclusions: The results showed that Pistacia lentiscus and Coriander Triphala are as effective as omeprazole in the treatment of GERD.

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supporting

confidence: 91%

Effects of Pistacia lentiscus and Coriander Triphala on Adult Gastroesophageal Reflux Disease: A Randomized Double-Blinded Clinical Trial

Sadeghi

Fazljou

Sepehri

et al. 2020

Iran Red Crescent Med J

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“…F unctional Dyspepsia (FD) as a non-ulcer dyspepsia [1] involves more than half of the patients with dyspepsia [2] and is a common gastrointestinal problem with a prevalence rate of 5-11% [3]. Its prevalence ranges from 2.2 to 29.9% in Iran [4]. FD does not cause death [5] but because it is considered a chronic condition [2], in addition to disrupting the quality of life [6], it also imposes significant financial and economic costs [4].…”

Section: Introductionmentioning

confidence: 99%

“…Its prevalence ranges from 2.2 to 29.9% in Iran [4]. FD does not cause death [5] but because it is considered a chronic condition [2], in addition to disrupting the quality of life [6], it also imposes significant financial and economic costs [4]. The main symptoms of dyspepsia are bothersome postprandial fullness, early satiation, epigastric pain, and epigastric burning in the absence of systemic, organic, or metabolic diseases existed in the past 3 months and at least started 6 months before diagnosis [2][3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…FD does not cause death [5] but because it is considered a chronic condition [2], in addition to disrupting the quality of life [6], it also imposes significant financial and economic costs [4]. The main symptoms of dyspepsia are bothersome postprandial fullness, early satiation, epigastric pain, and epigastric burning in the absence of systemic, organic, or metabolic diseases existed in the past 3 months and at least started 6 months before diagnosis [2][3][4][5][6][7][8]. Drugs, such as acid suppressors, prokinetics, proton pump inhibitors, H. pylori eradication therapy, anti-anxiety medications, and antidepressants are used to mitigate the symptoms of FD, but no definitive treatment has been introduced for it [2,3,9,10] thus, there is a need to evaluate new therapeutic methods.…”

Section: Introductionmentioning

confidence: 99%

“…Oral mastic has anti-Helicobacter pylori (H. pylori) effect [24][25][26] as well as digestive aid [16] and antioxidant [27] properties and has been studied as a complementary treatment in the Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS) [28]. In a previous study, the effect of applying 350 mg/BD of Pistacia atlantica resin for 4 weeks was compared with placebo and a significant decrease was observed in the severity and frequency of early satiation, pain, and nausea in the Pistacia atlantica-treated group compared to the placebo group [4]. Results of a clinical trial conducted on 148 patients with FD in 2010 in Greece showed that oral administration of 350 mg of mastic gum/ TDS for 3 weeks reduced the symptoms of dyspepsia compared to the placebo [29].…”

Section: Introductionmentioning

confidence: 99%

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Topical Mastic Oil for Treatment of Functional Dyspepsia: A Randomized , Triple-Blind Controlled Trial

Sattarzadeh

Shojaii

Toosi

et al. 2021

GMJ

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Background: The main goal of the present study was to evaluate the effect of topical mastic oil, compared to placebo on treatment of functional dyspepsia (FD). Materials and Methods: Sixty-three patients with FD were included. Thirty-two subjects received the topical mastic oil (10 drops/TDS after meal) with massage and 31 patients received topical sesame oil with massage. Both groups received pantoprazole (40 mg daily) along with oil and massage. The severity of early satiation, postprandial fullness, epigastric pain and epigastric burning was assessed after 4 weeks using the Visual Analogue Scale (VAS) as well as frequency of symptoms. Satisfaction with the treatment was also assessed using a researcher-made questionnaire. Changes in the severity of symptoms were evaluated by Friedman’s test. Results: Mean and standard deviation of age of the subjects were equal to 36.95±13.64 and 50 (79.4%) patients were female. Both groups experienced a significant decrease in the severity of all the four symptoms (P<0.001). The percentage of decrease in the severity of early satiation was significantly higher in the mastic group than the control group (76.03±34.91% vs. 37.24±38.86%, P=0.003). No significant differences were found in the percentage of decrease in the severity of postprandial fullness, epigastric pain and burning between the study groups (P=0.05, 0.06, and 0.13, respectively). The frequency of symptoms was decreased similarly in both groups. Satisfaction with the treatment was reported to be significantly higher in the mastic group than the sesame group (P=0.01). There were no intolerable side effects in both groups. Conclusion: Mastic oil reduced early satiation better than the placebo. In addition, satisfaction with the treatment was higher in the mastic group than the sesame group. [GMJ.2021;10:e1965]

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Non-Chinese herbal medicines for functional dyspepsia

Baez

Vargas

Arancibia

et al. 2023

Cochrane Database of Systematic Reviews

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Effect of “Pistacia atlantica” Resin (Baneh) on Functional Dyspepsia: A Double-Blind, Randomized Clinical Study

Cited by 7 publications

References 29 publications

Effects of Pistacia lentiscus and Coriander Triphala on Adult Gastroesophageal Reflux Disease: A Randomized Double-Blinded Clinical Trial

Effects of Pistacia lentiscus and Coriander Triphala on Adult Gastroesophageal Reflux Disease: A Randomized Double-Blinded Clinical Trial

Topical Mastic Oil for Treatment of Functional Dyspepsia: A Randomized , Triple-Blind Controlled Trial

Non-Chinese herbal medicines for functional dyspepsia

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