volume 93, issue 0, P2-P-216 2020
DOI: 10.1254/jpssuppl.93.0_2-p-216
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Wataru Morozumi,
Satoshi Inagaki,
Yuki Iwata
et al.

Abstract: In primary open angle glaucoma patients, inhibition of aqueous humor discharge due to accumulation of extracellular matrix (ECM) in trabecular meshwork (TM) is often observed. It is known as a cause of high intraocular pressure (IOP). A previous report showed that TM cells express 11 types of mechanoreceptor including Piezo 1. However, its role in TM cell is still unclear and this study has evaluated the effect of Piezo 1 on ECM expression level in TM. At first, we measured the IOP in mice treated with a Piezo…

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