Effect of Peripheral Opioid Receptor Agonists on Depressive Activity of Ethanol

Trigub, M. M.; Bogdanova, N. G.; Kolpakov, A. A.; Bashkatova, Valentina; Sudakov, S. K.

doi:10.1007/s10517-014-2448-6

Cited by 8 publications

(7 citation statements)

References 15 publications

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“…All peptides were manufactured by Tocris. The dose of these compounds was selected from the results of our previous experiments [5]. Metabolic indexes were evalua ted by means of indirect calorimetry.…”

Section: Methodsmentioning

confidence: 99%

Effect of Peptide Agonists of Peripheral Opioid Receptors on Operant Feeding Behavior and Food Motivation in Rats

2015

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We studied the effect of intragastric administration of peptide agonists of μ-opioid receptors (DAMGO) and δ-opioid receptors (DADLE) on food consumption and food motivation during operant feeding behavior of different intensity and effectiveness. To obtain one food granule, trained rats should press a lever 1 time (day 1), 2 times (day 2), 4 times (day 3), 8 times (day 4), 16 times (day 5), or 32 times (day 6). Activation of δ-opioid receptors in the stomach was followed by suppression of feeding behavior at low energy expenditure. The level of food motivation under these conditions practically did not differ from the control. Activation of μ-opioid receptors in the stomach suppressed energy-consuming feeding behavior, which was accompanied by an increase in the level of food motivation. It can be hypothesized that protein metabolites exhibiting μ-opioid activity probably provide afferent signals into CNS via the vagus nerve to terminate energy expenditure under adverse conditions (although food motivation is not satisfied). Food motivation under these conditions probably contributes to the behavior aimed towards the search for more available food.

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Section: Methodsmentioning

confidence: 99%

Effect of Peptide Agonists of Peripheral Opioid Receptors on Operant Feeding Behavior and Food Motivation in Rats

2015

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“…The first (control) group of animals (n = 10) was administered vehicle alone (water); the second group (n = 10) was administered 200 mg/kg DAMGO (Tocris Bioscience, Bristol, UK); and the third group (n = 10) was administered 200 mg/kg DADLE (Tocris Bioscience). The dose of the administered substances was selected on the basis of our previous experiments (Trigub et al, 2014;Bogdanova et al, 2015).…”

Section: Free Feeding Sessionmentioning

confidence: 99%

Involvement of Peripheral Opioid Receptors in the Realization of Food Motivation Into Eating Behavior

Sudakov

Bogdanova

2021

Front. Behav. Neurosci.

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The involvement of peripheral opioid receptors in the mechanisms of eating behavior is still unclear. The aim of this work was to study the role of peripheral, predominantly gastric mu and delta opioid receptors in the realization of food motivation in conditions of different energy costs for eating behavior. Experiments were performed under a between-sessions progressive ratio schedule of reinforcement in food-deprived rats. The level of food motivation was calculated using a self-developed method. Food intake, motor activity, and metabolic rate were recorded in fed and hungry animals. Results showed that intragastric administration of the mu opioid receptor agonist DAMGO led to an increase in the level of food motivation in the light variant of operant feeding behaviors. Food consumption did not change. At high costs for feeding behavior, the administration of DAMGO did not alter food motivation; however, food consumption and motor activity were reduced. Intragastric administration of the delta opioid receptor agonist DADLE did not lead to changes in the level of food motivation and physical activity, but inhibition of feeding behavior was observed in all reinforcement schedules. Three regulatory pathways of eating behavior in difficult food conditions by peripheral, predominantly gastric opioid receptors are hypothesized: environmental-inhibitory afferentations and suppression of the realization of food motivation into behavior; homeostatic-inhibitory action on food motivation; and rewarding-suppression of the anticipatory reinforcement.

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“…The opioid is a substance of synthetic and semi-synthetic origin, which is in its composition,morphochemically, related to opiate receptors and provides a certain psycho-vegetative action. The representative of this group is nalbuphine -a synthetic opioid of an agonist-antagonist group (agonist of k-receptors and an antagonist of mu-receptors) [4,5]. Unfortunately, uncontrolled use of opioids leads to an increase in drug addiction not only in Ukraine, but also in the world [6].…”

Section: Introductionmentioning

confidence: 99%

Changes in the Cell Squad of Iliac Lymph Nodes of White Rats in Case of Longterm Influence of Nalbufin

Valko

Holovatskyi

2018

EUREKA: Health Sciences

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The article presents data on the change in the cellular composition of the lymph nodes of the white rats, males of reproductive age, who received intramuscular opioid analgesics-nalbuphine every day for six weeks. The weekly dose of nalbuphine was gradually increased, creating a model of physical opioid dependence according to the patent of Ukraine No. 76564 U. All experimental animals were divided into 8 groups. Morphometric method was used to determine the relative number of cells of the lymphoid series-small, medium and large lymphocytes, blasts and plasmocytes in the cloak zone and the embryonic center of the secondary lymphoid nodes and brain strands of the lymph nodes. Morphometric studies were performed using a system of visual analysis of histological preparations.

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Effect of Peripheral Opioid Receptor Agonists on Depressive Activity of Ethanol

Cited by 8 publications

References 15 publications

Effect of Peptide Agonists of Peripheral Opioid Receptors on Operant Feeding Behavior and Food Motivation in Rats

Effect of Peptide Agonists of Peripheral Opioid Receptors on Operant Feeding Behavior and Food Motivation in Rats

Involvement of Peripheral Opioid Receptors in the Realization of Food Motivation Into Eating Behavior

Changes in the Cell Squad of Iliac Lymph Nodes of White Rats in Case of Longterm Influence of Nalbufin

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