Effect of Para-Aminobenzoic Acid on the Course of Retinal Degeneration in the rd10 Mouse

Galbinur, Tural; Obolensky, Alexey; Berenshtein, Eduard; Vinokur, Vladimir; Chowers, Itay; Chevion, Mordechai; Banin, Eyal

doi:10.1089/jop.2009.0020

Cited by 22 publications

(17 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thickness of the ONL was measured as previously described [29]. Briefly, ONL thickness was measured three times in the central part of each hemiretina and results from the corresponding retinal areas were averaged.…”

Section: Methodsmentioning

confidence: 99%

Characterization of physiological defects in adult SIRT6-/- mice

et al. 2017

Self Cite

View full text Add to dashboard Cite

The NAD+-dependent SIRT6 deacetylase was shown to be a major regulator of lifespan and healthspan. Mice deficient for SIRT6 develop a premature aging phenotype and metabolic defects, and die before four weeks of age. Thus, the effect of SIRT6 deficiency in adult mice is unknown. Here we show that SIRT6-/- mice in mixed 129/SvJ/BALB/c background reach adulthood, allowing examination of SIRT6-related metabolic and developmental phenotypes in adult mice. In this mixed background, at 200 days of age, more than 80% of the female knock-out mice were alive whereas only 10% of male knock-out mice survived. In comparison to their wild-type littermates, SIRT6 deficient mice have reduced body weight, increased glucose uptake and exhibit an age-dependent progressive impairment of retinal function accompanied by thinning of retinal layers. Together, these results demonstrate a role for SIRT6 in metabolism and age-related ocular changes in adult mice and suggest a gender specific regulation of lifespan by SIRT6.

show abstract

Section: Methodsmentioning

confidence: 99%

Characterization of physiological defects in adult SIRT6-/- mice

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…Much better outcomes in DR and RP can thus be expected if antioxidant therapy is started before gross changes are evident. However, testing the effectiveness of an antioxidant against rod oxidative stress has mostly relied on post-mortem studies and/or observing improvements in animal models following (often pleiotropic) anti-oxidant therapy (Berkowitz et al, 2007c(Berkowitz et al, , 2012a(Berkowitz et al, , 2009bCampochiaro et al, 2015;Du et al, 2013Du et al, , 2015Fukuda et al, 2014;Galbinur et al, 2009;Jaliffa et al, 2009;Komeima et al, 2006;Rohrer et al, 2004;Sanz et al, 2007;Usui et al, 2009a;Yang et al, 2007;Zeng et al, 2014;Zheng et al, 2007). Such approaches i) are often unable to determine whether oxidative stress in rod cells per se has been corrected, and ii) are not useful for examining the same animal over time or for examining rod cell oxidative stress in patients.…”

Section: Introductionmentioning

confidence: 99%

MRI of rod cell compartment-specific function in disease and treatment in vivo

Berkowitz

Bissig

Roberts

2016

Progress in Retinal and Eye Research

View full text Add to dashboard Cite

Rod cell oxidative stress is a major pathogenic factor in retinal disease, such as diabetic retinopathy (DR) and retinitis pigmentosa (RP). Personalized, non-destructive, and targeted treatment for these diseases remains elusive since current imaging methods cannot analytically measure treatment efficacy against rod cell compartment-specific oxidative stress in vivo. Over the last decade, novel MRI-based approaches that address this technology gap have been developed. This review summarizes progress in the development of MRI since 2006 that enables earlier evaluation of the impact of disease on rod cell compartment-specific function and the efficacy of anti-oxidant treatment than is currently possible with other methods. Most of the new assays of rod cell compartment-specific function are based on endogenous contrast mechanisms, and this is expected to facilitate their translation into patients with DR and RP, and other oxidative stress-based retinal diseases.

show abstract

“…It is a building block used in design of drugs and frequently found as a structure moiety in drugs [5]. p ABA exhibits a wide range of therapeutic uses as antioxidant [6], [7], antibacterial [8], [9], antimutagenic [10], anticoagulant [11], [12], fibrinolytic and immunomodulating agent [13], protective drug against UV-irradiation [14]–[16] and in diagnostic tests for the state of the gastrointestinal tract [17], [18].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Crystal Structure and Biological Activity of 2-Hydroxyethylammonium Salt of p-Aminobenzoic Acid

et al. 2014

View full text Add to dashboard Cite

p-Aminobenzoic acid (pABA) plays important roles in a wide variety of metabolic processes. Herein we report the synthesis, theoretical calculations, crystallographic investigation, and in vitro determination of the biological activity and phytotoxicity of the pABA salt, 2-hydroxyethylammonium p-aminobenzoate (HEA-pABA). The ability of neutral and anionic forms of pABA to interact with TIR1 pocket was investigated by calculation of molecular electrostatic potential maps on the accessible surface area, docking experiments, Molecular Dynamics and Quantum Mechanics/Molecular Mechanics calculations. The docking study of the folate precursor pABA, its anionic form and natural auxin (indole-3-acetic acid, IAA) with the auxin receptor TIR1 revealed a similar binding mode in the active site. The phytotoxic evaluation of HEA-pABA, pABA and 2-hydroxyethylamine (HEA) was performed on the model plant Arabidopsis thaliana ecotype Col 0 at five different concentrations. HEA-pABA and pABA acted as potential auxin-like regulators of root development in Arabidopsis thaliana (0.1 and 0.2 mM) and displayed an agravitropic root response at high concentration (2 mM). This study suggests that HEA-pABA and pABA might be considered as potential new regulators of plant growth.

show abstract

Effect of Para-Aminobenzoic Acid on the Course of Retinal Degeneration in the rd10 Mouse

Cited by 22 publications

References 36 publications

Characterization of physiological defects in adult SIRT6-/- mice

Characterization of physiological defects in adult SIRT6-/- mice

MRI of rod cell compartment-specific function in disease and treatment in vivo

Synthesis, Crystal Structure and Biological Activity of 2-Hydroxyethylammonium Salt of p-Aminobenzoic Acid

Contact Info

Product

Resources

About