Effect of palm vitamin E on the healing of ethanol-induced gastric injury in rats

Jaarin, Kamsiah; Renuvathani, M.; Nafeeza, M. I.; Gapor, M. T.

doi:10.1080/096374800111113

Cited by 8 publications

(8 citation statements)

References 9 publications

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“…The metabolism of EtOH generates superoxide radicals supporting lipid peroxidation which is known to be a mechanism of ethanol-induced gastric mucosal injury. Moreover, MDA is known to be a good indicator of the degree of lipid peroxidation [22][23][24][25]. In the current study, parallel to ulcer formation, a significant elevation in MDA content was observed once ethanol given orally and also indicate that SF pretreatment significantly prevents MDA production implying the idea that reduction in lipid peroxidation and cellular injury protecting the gastric tissue against ethanol-induced oxidative damage.…”

Section: Discussionsupporting

confidence: 61%

Potential protective effects of silk fibroin against ethanol induced gastric ulcer

Aykaç¹,

Karanlik²,

Şehirli³

2018

mpj

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Ulcers that develop due to alcohol consumption are frequently confronted. The aim of this study was to investigate the protective effects of silk fibroin on the pro-apoptotic and anti-apoptotic protein expression levels on ethanol induced-ulcer models in rats. For three consecutive days, orogastrically either silk fibroin or saline were given to rats. On the 4th day, animals were deprived of food but allowed free access to water for 24 h before the experiment. While control groups were treated with only physiological saline, the ulcer groups were treated orally either with saline or silk fibroin groups. For ulcer induction, 1 ml of absolute ethanol by gavage were given to both group. Firstly, intracardiac blood was taken at 60 min of EtOH or saline administration and immediately animals were decapitated. In blood samples, the amount of TNF-, IL-1β were analysed whereas in stomach tissues, the levels of MDA, GSH, and MPO activity and the expression levels of bcl-2, Bax, caspase-3 and-9 were determined. In ulcer groups, the amount of TNF- , IL-1β, MDA, MPO, caspase-3 and caspase-9 were found to be significantly higher compared to control groups whereas in GSH, Bcl-2/Bax were found to be lower (p < 0.005). In treatment groups it is observed that silk fibroin recovers the amount of TNF-, IL 1-β, MDA, MPO, GSH, caspase-3, caspase-9, and Bcl-2/Bax. In conclusion, for the treatment of the gastric ulcer SF thought to be very efficient therapeutic agent.

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Section: Discussionsupporting

confidence: 61%

Potential protective effects of silk fibroin against ethanol induced gastric ulcer

Aykaç¹,

Karanlik²,

Şehirli³

2018

mpj

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“…PVE was also shown to be effective in increasing the PGE 2 level in rats given indomethacin [239] but not in ethanol-induced ulcers [246]. Prostaglandin is produced from arachidonic acid by the action of cyclooxygenase (COX) enzyme.…”

Section: Effects Of Tocotrienol On Peptic Ulcersmentioning

confidence: 99%

“…Another important protective factor in the gastric mucosa is the mucus covering it [251]. However, the gastric adherent mucus content was unaltered in rats fed with a diet containing various doses of TRF (60, 100, 150, and 300 mg/kg) for 4-8 weeks and administered absolute ethanol even though there was a reduction in gastric lesion index compared to the untreated control [240,242,244,246,249]. A similar finding was also observed in rats given a diet containing αTF (20, 30, 50, and 300 mg/kg) for 4-8 weeks and challenged with aspirin [240,242], which confirms that neither T3 or TF exerts any significant effect on gastric mucus production.…”

Section: Effects Of Tocotrienol On Peptic Ulcersmentioning

confidence: 99%

Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence

et al. 2020

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Tocotrienol (T3) is a subfamily of vitamin E known for its wide array of medicinal properties. This review aimed to summarize the health benefits of T3, particularly in prevention or treatment of non-communicable diseases (NCDs), including cardiovascular, musculoskeletal, metabolic, gastric, and skin disorders, as well as cancers. Studies showed that T3 could prevent various NCDs, by suppressing 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in the mevalonate pathway, inflammatory response, oxidative stress, and alternating hormones. The efficacy of T3 in preventing/treating these NCDs is similar or greater compared to tocopherol (TF). TF may lower the efficacy of T3 because the efficacy of the combination of TF and T3 was lower than T3 alone in some studies. Data investigating the effects of T3 on osteoporosis, arthritis, and peptic ulcers in human are limited. The positive outcomes of T3 treatment obtained from the preclinical studies warrant further validation from clinical trials.Nutrients 2020, 12, 259 2 of 84 Nutrients 2020, 12, 259 4 of 84 the order δ > γ > β > α [45]. Using HepG2 cells, γT3 was shown to stimulate apolipoprotein B (Apo-B) degradation by decreasing its translocation into the endoplasmic reticulum (ER) lumen. This action eventually caused a reduction in the number of Apo-B in lipoprotein particles [46]. Other reports showed that γT3 and δT3 had the potential to reduce the hepatic TG synthesis and very-low-density lipoprotein (VLDL) secretion by suppressing expression of genes involved in lipid homeostasis, particularly the TG, cholesterol, and VLDL biosynthesis. Moreover, δT3 also promoted the efflux of LDL through LDL receptor expression [47]. A summary of the literature on effect of T3 supplementation on lipid profile of hypercholesterolemic model in vitro is shown in Table 1.Animal models of dyslipidemia have been used to investigate the effects of T3 on lipid profile. Several animals have been tested, including chicken, swine and rodents (rats, hamsters, guinea pigs). In chickens fed with a varying level of αTF and γT3, Qureshi et al. (1996) showed that αTF enhanced the inhibition of HMGCR by γT3. They further stipulated that the vitamin E mixture should contain 15-20% of αTF and approximately 60% of γT3 or δT3 for optimal anti-cholesterol effects [48]. In the subsequent study, demonstrated that combination of 50 ppm T3-rich fraction (TRF) and 50 ppm lovastatin was more effective in suppressing HMGCR activity compared to lovastatin alone in chickens. The combination also reduced serum TC and LDL-C, TG, Apo-B, thromboxane B 2 , and platelet factor 4 in contrast to individual treatment [49]. Using chicken supplemented with 50 ppm of δT3, Qureshi et al. (2011) further revealed that δT3 reduced TC and LDL-C besides suppressing the lipid elevating effects of dexamethasone and potentiated the TG-lowering effect of riboflavin [50]. Using genetically hypercholesterolemic swine, Qureshi et al. (1991) demonstrated the significant effect of TRF in lowering serum TC, LDL-C, Apo-B, thrombo...

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“…The mucus covers the mucosa of the gastrointestinal tract (Repetto & Llesuy, 2002). The gastric adherent mucus content was unaltered in rats that were fed a diet containing various doses of tocotrienol-rich fraction (60, 100, 150, and 300 mg/kg) for 4-8 weeks and administered absolute ethanol, indomethacin, or aspirin even though there was a reduction in gastric lesion index compared with the untreated control (Jaarin et al, 1999(Jaarin et al, , 2000(Jaarin et al, , 2002Nafeeza et al, 2002;Qodriyah et al, 2002). A similar finding was also observed in rats given a diet containing a-tocopherol (20, 30, 50, and 300 mg/kg) for 4-8 weeks and challenged with aspirin (Jaarin et al, 2002;Nafeeza et al, 2002).…”

Section: Diminished Endogenous Gastroprotective Factorsmentioning

confidence: 99%

“…On one hand, a-tocopherol increased gastric PGE 2 level in many gastric lesion models (Fesharaki et al, 2006, Jiang et al, 2009Tariq, 1988). Tocotrienol, on the other hand, was also not effective in increasing the PGE 2 level in rats given indomethacin (Qodriyah et al, 2002) or ethanol (Jaarin et al, 2000). However, when the two were combined, a protective effect of the combination was observed (Nafeeza & Kang, 2005).…”

Section: Diminished Endogenous Gastroprotective Factorsmentioning

confidence: 99%

Vitamin E: A potential therapy for gastric mucosal injury

Kamisah¹,

Qodriyah²,

Chua

et al. 2014

Pharmaceutical Biology

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Effect of palm vitamin E on the healing of ethanol-induced gastric injury in rats

Cited by 8 publications

References 9 publications

Potential protective effects of silk fibroin against ethanol induced gastric ulcer

Potential protective effects of silk fibroin against ethanol induced gastric ulcer

Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence

Vitamin E: A potential therapy for gastric mucosal injury

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