Laminated Ti-Al composite sheets with different mesostructures have been fabricated through hot pressing. The influence of mesostructure on mechanical properties of the composite is investigated. The results indicate that with the increase of sintering temperature, different mesostructures of composite are obtained, that is, laminated Ti/Ti-Al composite, laminated Ti 3 Al/TiAl composite, and monolithic Ti 3 Al/TiAl composite. The mechanical properties tests reveal that laminated Ti/Ti-Al composite exhibits better comprehensive mechanical properties, including flexural strength, fracture toughness, and microhardness, than those of laminated Ti 3 Al/TiAl composite and monolithic Ti 3 Al/TiAl composite. The fracture analysis shows that the propagation route of crack is zigzag for Ti/Ti-Al composite, curving for laminated Ti 3 Al/TiAl composite, and approximately a straight line for monolithic Ti 3 Al/TiAl composite. The relevant strengthening and toughening mechanism of the composites is discussed.