Effect of Optimization of Tween 80 and Propylene Glycol as a Surfactant and Cosurfactant on the Physical Properties of Aspirin Microemulsion

Yati, Kori; Srifiana, Yudi; Putra, Farensyah

doi:10.22159/ijap.2017.v9s1.71_78

Cited by 10 publications

(8 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This can be explained by better emulsification due to the reduction of the oil/water interfacial tension, which makes it possible to reduce the size of the globules of microemulsions [37]. These results are consistent with previous research in which the addition of surfactant to the microemulsion system causes condensation and stability of the interfacial film, while the addition of the co-surfactant causes expansion of the interfacial film [38,39]. Smaller globule size is an important parameter affecting microemulsion stability, skin penetration and hence in vivo efficacy [40].…”

Section: Prediction Point Analysissupporting

confidence: 90%

Formulation, Optimization and Characterization of Ibuprofen Loaded Microemulsion System Using D-Optimal Mixture Design

et al. 2019

View full text Add to dashboard Cite

Objective: The purpose of this study was to develop, optimize and characterize a stable microemulsion, with an improvement of the solubility of a poorly aqueous soluble drug, ibuprofen. Methods: Various oils (oleic acid, cottonseed oil, olive oil, argan oil, and labrafac® WL 1349), surfactants (tween® 80, tween® 40, tween® 20) and co-surfactants including polyethylene glycol 400, ethanol, 1-butanol, and propylene glycol were selected after solubility studies. Then, pseudo-ternary phase diagrams with surfactant/co-surfactant ratio of 1:2, 1:1, 2:1 and 3:1 were constructed and a D-optimal mixture design method was used to optimize the ibuprofen loaded microemulsion. The optimized microemulsion was evaluated for several characteristics including globule size, zeta potential, pH, conductivity, refractive index and stability studies. Results: Optimized microemulsion obtained was composed of oleic acid (6.88% w/w), tween® 80/1-butanol (3:1, 63.11% w/w) and water (30.00% w/w). The results obtained showed an average globule size of 117.5 nm, a zeta potential of-6.47 mV and a transmittance of 96.95±0.77%. The optimized formulation showed an improvement in the solubility of ibuprofen with unchanged characteristics for one month. Conclusion: The use of pseudo-ternary phase diagrams and mathematical modeling allows to obtain an optimal microemulsion with perfect stability for 1 mo and a better solubilization capacity of ibuprofen.

show abstract

Section: Prediction Point Analysissupporting

confidence: 90%

Formulation, Optimization and Characterization of Ibuprofen Loaded Microemulsion System Using D-Optimal Mixture Design

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Shear pressure and shear rate (RPM) were poured in a theological pattern. This type of flow test was performed only at week 0 [20].…”

Section: Flow Type Testmentioning

confidence: 99%

Formulation Development and Characterization of Snakehead Fish Powder in Oral Double Emulsion

Tungadi

Imran

2018

Int J App Pharm

View full text Add to dashboard Cite

Objective: Snakehead fish has been scientifically proven to increase levels of albumin and boost the immune system so that the formulation development is required. The objective of this study was to formulate and characterize snakehead fish powder (SFP) in the form of the oral double emulsion.Methods: The manufacture of snakehead fish powder used the conventional method with dry heating at 50 °C. Characterization of SFP utilized proximate analysis method per 3 g of SFP. The double emulsion preparation was carried out by mixing 30% of the primary emulsion (w/o) into 70% of the secondary emulsion (w) to form the w/o/w emulsion. This preparation was prepared in 4 formulas having variations in Tween 80 concentrations at the secondary emulsions of 0.7%, 3.5%, 7.0% and 10.5% w/v, respectively using the spontaneous emulsification method. After that, all formulations were doing some tests, i.e. organoleptic test, pH, viscosity, flow types, globular diameter test and stability tests.Results: The results of proximate analysis every 3 g of SFP have obtained the contents of protein, 16.89%, lipid 24.52%, water 1.73% and ash 1.05%. Based on the optimization of the formula, the preparation of F4 with the content of Tween 80 at 10.5% secondary emulsion is the best formula due to slow phase separation, pH 7, unchanged organoleptic properties, large internal and external globular diameter (6.35 μm and 8.9 μm), as well as having a high viscosity value (1569.84 p) which correspond to pseudo plastic flow.Conclusion: The novelty of SFP can be developed as double emulsion orally based on the results of characterization and evaluation of double emulsion.

show abstract

“…Therefore, the activity of methylparaben as a preservative decreased, and resulted in a growth of microorganisms [ 24 , 25 ]. The use of PG > 10% can prevent interactions between methylparaben and tween 80 [ 26 , 27 ]. However, the film-forming solution had poor sprayability and prolonged film-drying time, so the PG concentration used was less than 10%.…”

Section: Resultsmentioning

confidence: 99%

“…This phenomenon may have been due to the high temperature generated by the probe sonicator, which can degrade hEGF [ 25 , 26 ]. In addition, using a probe sonicator for an extended period of time can cause the lipids to become de-esterified, and titanium on the probe can slough off and pollute the solution [ 27 ]. Therefore, the sonication process was carried out using a bath sonicator.…”

Section: Discussionmentioning

confidence: 99%

Film-Forming Spray of Water-Soluble Chitosan Containing Liposome-Coated Human Epidermal Growth Factor for Wound Healing

et al. 2021

View full text Add to dashboard Cite

Human epidermal growth factor (hEGF) has been known to have excellent wound-healing activity. However, direct application to the wound area can lead to low hEGF bioavailability due to protease enzymes or endocytosis. The use of liposomes as coatings and carriers can protect hEGF from degradation by enzymes, chemical reactions, and immune reactions. Sustained release using a matrix polymer can also keep the levels of hEGF in line with the treatment. Therefore, this study aimed to develop a film-forming spray of water-soluble chitosan (FFSWSC) containing hEGF-liposomes as a potential wound dressing. The hEGF-liposomes were prepared using the hydration film method, and the preparation of the FFSWSC was achieved by the ionic gelation method. The hydration film method produced hEGF-liposomes that were round and spread with a Z-average of 219.3 nm and encapsulation efficiency of 99.87%, whereas the film-forming solution, which provided good sprayability, had a formula containing 2% WSC and 3% propylene glycol with a viscosity, spray angle, droplet size, spray weight, and occlusion factor of 21.94 ± 0.05 mPa.s, 73.03 ± 1.28°, 54.25 ± 13.33 µm, 0.14 ± 0.00 g, and 14.57 ± 3.41%, respectively. The pH, viscosity, and particle size of the FFSWSC containing hEGF-liposomes were stable during storage for a month in a climatic chamber (40 ± 2 °C, RH 75 ± 5%). A wound healing activity test on mice revealed that hEGF-liposomes in FFSWSC accelerated wound closure significantly, with a complete wound closure on day 6. Based on the findings, we concluded that FFSWSC containing hEGF-liposomes has the potential to be used as a wound dressing.

show abstract

Effect of Optimization of Tween 80 and Propylene Glycol as a Surfactant and Cosurfactant on the Physical Properties of Aspirin Microemulsion

Cited by 10 publications

References 1 publication

Formulation, Optimization and Characterization of Ibuprofen Loaded Microemulsion System Using D-Optimal Mixture Design

Formulation, Optimization and Characterization of Ibuprofen Loaded Microemulsion System Using D-Optimal Mixture Design

Formulation Development and Characterization of Snakehead Fish Powder in Oral Double Emulsion

Film-Forming Spray of Water-Soluble Chitosan Containing Liposome-Coated Human Epidermal Growth Factor for Wound Healing

Contact Info

Product

Resources

About