Effect of Oils Containing Unsaturated Fatty Acids on Patients With Dermatitis

Ginsberg, Julius E.

doi:10.1001/archderm.1937.01480050099013

Cited by 26 publications

(3 citation statements)

References 13 publications

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“…Taub and Zakon (1935) found no benefit in eight cases of atopic eczema (Besnier's prurigo, disseminated neurodermatitis) which they treated with linseed oil by mouth, and also pointed out that the use of linseed or cottonseed oil might be dangerous, a3 the patient could be sensitive to these sources of U.F.A.s. Ginsberg and Bernstein (1937) found satisfactory improvement in three adults in a group of 11 with atopic dermatitis and in four out of six children. They also pointed out, however, that two children receiving the same local treatment and no added U.F.A.s improved in the same time.…”

Section: Discussionmentioning

confidence: 87%

Use of Unsaturated Fatty Acids in the Eczemas of Childhood

Pettit¹

1954

BMJ

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Section: Discussionmentioning

confidence: 87%

Use of Unsaturated Fatty Acids in the Eczemas of Childhood

Pettit¹

1954

BMJ

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“…Several studies done in this field show, although with discordant results, positive therapeutic effects on the AD severity after dietetic supplementary LA and AGL [13][14][15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Essential Fatty Acids in Neonates at Risk for Atopy

Cantani¹

2015

J Biomol Res Ther

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Essential fatty acids (EFA) are the major components of cellular phospholipids (PLs), contributing to their stability and functions. They are also precursors of inflammation mediators such as prostaglandins and leukotrienes, and are involved in cellular immunoregulation.Most recent studies have stressed that EFA levels are important in various diseases. Several Authors have stated that patients with atopic dermatitis (AD) have altered EFA levels in plasmatic PLs, and showed clinical improvement after oral EFA administration. The aim of our work was to study EFA composition of PLs of cord blood lymphocytes in 32 newborns at risk for atopy, in order to correlate EFA levels at birth with total IgE values and with the onset of atopic disease. Thirty not at risk newborns were studied as controls.Our results demonstrate a significant decrease (p<0.0001) of arachidonic acid (AA) levels in lymphocytes of newborns at risk for atopy, compared to controls, whereas a not significant increase of linoleic acid (LA) was present. No reverse correlation between IgE values and AA levels was found, whereas the 6 month and 1 year follow-up have not shown any major alteration of total IgE values, on the contrary a normalization of AA levels in all but one child has been observed. Only this one child has developed AD. We stress that the preventive action on allergy development recognized to breast milk could be also due to its effect on the EFA composition of the PLs of cell membrane.

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“…He advocated dietary EFA supplementation for treatment of childhood eczema. Results of clinical trials were variable [13][14][15][16][17][18][19], and dietary treatment of eczema was eclipsed by treatment with adrenal corticosteroids. Even today, with the art of clinical observation being undervalued in medical education, knowledgeable dermatologists know that allergic individuals often have dry skin and follicular kératoses, another manifestation of human EFA deficiency [20].…”

Section: Introductionmentioning

confidence: 99%

Increased requirements for essential fatty acids in atopic individuals: a review with clinical descriptions.

Galland¹

1986

Journal of the American College of Nutrition

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Patients with atopic eczema and a mixture of allergic illnesses show biochemical evidence suggesting impairment in the desaturation of linoleic acid and linolenic acid by the enzyme delta-6 dehydrogenase. Consequences of this enzyme defect are 1) diminished synthesis of the 20-carbon polyunsaturated fatty acids, which are prostaglandin precursors and 2) a reduction in the concentration of double bonds in the cell membrane. A distortion in the production of prostaglandins and leukotrienes, which might result from this block, can account for the immunological defects of atopy and a variety of clinical symptoms experienced by atopic individuals. Dietary supplementation with essential fatty acids relieves the signs and symptoms of atopic eczema, may improve other types of allergic inflammation, and may also correct coexisting symptoms as diverse as excessive thirst and dysmenorrhea. Further research is suggested to test the hypothesis that some atopic states represent a condition of essential fatty acid dependency owing to defective desaturation of dietary fatty acids.

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Effect of Oils Containing Unsaturated Fatty Acids on Patients With Dermatitis

Cited by 26 publications

References 13 publications

Use of Unsaturated Fatty Acids in the Eczemas of Childhood

Use of Unsaturated Fatty Acids in the Eczemas of Childhood

Assessment of the Essential Fatty Acids in Neonates at Risk for Atopy

Increased requirements for essential fatty acids in atopic individuals: a review with clinical descriptions.

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