Effect of oil sands process-affected water on toxicity of retene to early life-stages of Japanese medaka (Oryzias latipes)

Alharbi, Hattan A.; Morandi, Garrett; Giesy, John P.; Wiseman, Steve

doi:10.1016/j.aquatox.2016.04.009

Cited by 24 publications

(19 citation statements)

References 61 publications

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“…Compared to conventional crudes, middle distillates and heavy fuel oils, very little is known about the toxicity of dilbits and synthetic crudes derived from bitumen (Dew et al 2015). Previous studies have reported the toxicity of bitumen, bitumen extracts, or process water from the Alberta tar sands region of Canada (e.g., Colavecchia et al 2004;Alharbi et al 2016;Bauer et al 2017). The toxicity of a few dilbits has only recently been reported in three species of fish, and there has been no published studies on the toxicity to freshwater or saltwater invertebrates or estuarine fish species (Madison et al 2015(Madison et al , 2017Alderman et al 2016;Philibert et al 2016).…”

Section: Discussionmentioning

confidence: 99%

Toxicity of Cold Lake Blend and Western Canadian Select dilbits to standard aquatic test species

et al. 2018

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Dilbits are blends of bitumen and natural gas condensates or crude oils with only limited toxicity data. Two dilbits, Cold Lake Blend and Western Canadian Select, were tested as either unweathered or weathered oils for acute and chronic toxicity to standard freshwater and estuarine organisms. Water accommodated fractions of the dilbits were characterized for total petroleum hydrocarbons (TPH), polycyclic aromatic hydrocarbons (PAHs), and monoaromatics (BTEX). Acute toxicity of unweathered and weathered dilbits ranged from 4 to 16 mg/L TPH, 8 to 40 μg/L total PAHs, and 0.7 to 16 mg/L BTEX in Ceriodaphnia dubia, Pimephales promelas, Americamysis bahia, and Menidia beryllina. Concentrations of weathered dilbits causing impaired growth (A. bahia) and reproduction (C. dubia) ranged from 0.8 to 3.5 mg/L TPH and 6 to 16 μg/L PAHs. The two dilbits had generally similar acute and short term chronic toxicity expressed as TPH or total PAHs as other crude oils and other petroleum products.

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Section: Discussionmentioning

confidence: 99%

Toxicity of Cold Lake Blend and Western Canadian Select dilbits to standard aquatic test species

et al. 2018

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“…The by-product water produced after mining, commonly referred to as oil sands process affected water (OSPW), is currently subject to a ‘zero discharge policy’ and is collected and stored in tailings ponds or recycled into process operations [3] , [4] . OSPW consists of process contaminated water with unrecovered bitumen, petroleum based chemicals, sand, heavy metals, and other inorganic compounds [5] , [6] , [7] . The organic fraction in OSPW is comprised of a myriad of contaminants of which naphthenic acids (NA) are the primary recalcitrants causing serious environmental issues and exhibiting chronic and acute toxicity [5] , [6] , [7] .…”

Section: Introductionmentioning

confidence: 99%

Insights into ultrasound-promoted degradation of naphthenic acid compounds in oil sands process affected water. Part I: Accelerated H-abstraction and decarboxylation of aromatic and alicyclic compounds

Ansari

Kirpalani

2022

Ultrasonics Sonochemistry

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“…Because results of the in vitro assay indicated that basic and neutral compounds, but not acidic compounds, in the water‐soluble organic fraction of OSPW inhibit P‐gp, a method that isolates basic and neutral compounds into one fraction and contains smaller amounts of acidic compounds was used to prepare samples for assays with embryos (Vieno et al ., ). Details of this method have been described previously (Alharbi et al ., ). Briefly, 1000 ml of OSPW was passed through a glass microfiber filter (GF/D 0.47 mm; Whatman) to remove any particulate matter and the pH of the OSPW adjusted to pH 9 by use of NH 4 OH.…”

Section: Methodsmentioning

confidence: 97%

“…Therefore, the concentration of dissolved organic compounds in the final sample was 2000× greater than in the original sample of OSPW. The profile of heteroatom classes in these fractions has been described previously (Alharbi et al ., ).…”

Section: Methodsmentioning

confidence: 97%

Toxicokinetics and toxicodynamics of chlorpyrifos is altered in embryos of Japanese medaka exposed to oil sands process‐affected water: evidence for inhibition of P‐glycoprotein

Alharbi

Alcorn

Almousa

et al. 2016

J of Applied Toxicology

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Oil sands process-affected water (OSPW) is generated during extraction of bitumen in the surface mining oil sands industry in Alberta, Canada. Studies were performed in vitro by use of Caco-2 cells, and in vivo with larvae of Japanese medaka (Oryzias latipes) to determine if organic compounds from the aqueous phase of OSPW inhibit ATP binding cassette protein ABCB1 (permeability-glycoprotein, P-gp). Neutral and basic fractions of OSPW inhibited activity of P-gp in Caco-2 cells by 1.9- and 2.0-fold, respectively, while the acidic fraction had the least effect. The organophosphate pesticides chlorpyrifos (a substrate of P-gp) and malathion (not a substrate of P-gp), were used as model chemicals to investigate inhibition of P-gp in larvae. Co-exposure to chlorpyrifos and an extract of OSPW containing basic and neutral compounds reduced survival of larvae to 26.5% compared to survival of larvae exposed only to chlorpyrifos, which was 93.7%. However, co-exposure to malathion and the extract of OSPW did not cause acute lethality compared to exposure only to malathion. Accumulation and bioconcentration of chlorpyrifos, but not malathion, was greater in larvae co-exposed with the extract of OSPW. The terminal elimination half-life of chlorpyrifos in larvae exposed to chlorpyrifos in freshwater was 5 days compared with 11.3 days in larvae exposed to chlorpyrifos in OSPW. Results suggest that in non-acute exposures, basic and neutral organic compounds in the water-soluble fraction of OSPW inhibit activity of P-gp, which suggests that OSPW has the potential to cause adverse effects by chemosensitization. Copyright © 2016 John Wiley & Sons, Ltd.

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Effect of oil sands process-affected water on toxicity of retene to early life-stages of Japanese medaka (Oryzias latipes)

Cited by 24 publications

References 61 publications

Toxicity of Cold Lake Blend and Western Canadian Select dilbits to standard aquatic test species

Toxicity of Cold Lake Blend and Western Canadian Select dilbits to standard aquatic test species

Insights into ultrasound-promoted degradation of naphthenic acid compounds in oil sands process affected water. Part I: Accelerated H-abstraction and decarboxylation of aromatic and alicyclic compounds

Toxicokinetics and toxicodynamics of chlorpyrifos is altered in embryos of Japanese medaka exposed to oil sands process‐affected water: evidence for inhibition of P‐glycoprotein

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