Effect of Obstructive Sleep Apnea on Aortic Elastic Parameters

Tanrıverdi, Halil; Evrengül, Harun; Kaftan, Asuman; Kara, Cüneyt Orhan; Kuru, Ömür; Tanrıverdi, Seyhan; Özkurt, Sibel; Semiz, Ender

doi:10.1253/circj.70.737

Cited by 30 publications

(23 citation statements)

References 36 publications

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“…Tanriverdi et al 55 found that the stiffness index of OSA patients was higher as compared to control patients, and that aortic distensibility was lower than in control patients. They also noted a correlation between aortic stiffness and RDI as well as a negative correlation between RDI and distensibility (r¼À0.41, P¼0.001).…”

Section: Resultsmentioning

confidence: 98%

Increased arterial stiffness in obstructive sleep apnea: a systematic review

et al. 2010

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Obstructive sleep apnea is a prevalent disease that is associated with significant morbidity and mortality, particularly due to cardiovascular disease. An emerging cardiovascular risk factor, arterial stiffness, may also be involved in the cardiovascular complications of obstructive sleep apnea. The purpose of this review was to summarize the current literature regarding the effect of obstructive sleep apnea on arterial stiffness. We conducted a systematic literature review using PubMed, Embase and the Cochrane Library. We identified 24 studies that met search criteria investigating the effect of obstructive sleep apnea on arterial stiffness. Arterial stiffness was found to be increased in obstructive sleep apnea patients compared with controls or increased in severe compared with mild sleep apnea. In some studies, a positive correlation was identified between the degree of arterial stiffness and sleep apnea severity. In the two randomized, controlled trials and the two nonrandomized trials identified, treatment of obstructive sleep apnea with continuous positive airway pressure led to significant decreases in arterial stiffness. Obstructive sleep apnea appears to have an independent effect on arterial stiffness, which may be one of the mechanisms accounting for sleep apnea-associated cardiovascular risk.

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Section: Resultsmentioning

confidence: 98%

Increased arterial stiffness in obstructive sleep apnea: a systematic review

et al. 2010

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“…In the previous studies the relationship between aortic stiffness and the myocardial mass and functions has been presented. 9,18 Some structural changes occur in the myocardium when the end-systolic stress increases. Thus, systolic and diastolic stiffness develops in the myocardium.…”

Section: Discussionmentioning

confidence: 99%

“…8 In the present study, we reported that there might possibly be a relationship between the increment in aortic stiffness and left ventricular (LV) diastolic dysfunction. 9 In the current study our objective was to investigate the elastic properties of the aorta in the patients with CE and the relationship between these characteristics and LV diastolic functions. …”

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confidence: 99%

Aortic Elastic Properties in Patients With Coronary Artery Ectasia

Tüzün

Tanrıverdi

Evrengül

et al. 2007

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oronary ectasia (CE) is a clinical situation which is characterized by luminal widening of the coronary arteries and the resultant decrease in the coronary blood flow. Its incidence has been reported to be between 0.3% and 4.9% in the autopsy and cardiac catheterization series. 1 Coronary atherosclerosis (50%), congenital diseases (20%), inflammatory diseases (10-20%), collagenous and connective tissue diseases are presumed to be responsible for its cause. 2 The essential histopathological finding in the diagnosis of CE is the replacement of coronary artery media layer smooth muscle cells with hyalinized collagen, as a consequence of the increased degeneration of the media layer. 3 As a result, the loss of musculo-elastic components is observed in the media. 2 Thus, progressive artery dilatation occurs. Moreover, along with this disease, the presence of extracardiac artery dilatation has been reported in the previous studies. 4,5 Arterial stiffness, which is defined as the arterial rigidity caused by the loss of elastic tissue in the artery wall, decreases the widening capacity of the artery. Many studies searching the effects of the cardiovascular risk factors on the arteries showed that, as a consequence of the structural changes in the arteries caused by these risk factors, arterial rigidity develops and arterial widening capacity is deteriorated. It has been established that as the stiffness of the large arteries such as aorta increases, cardiovascular mortality and morbidity also increase. 6 Consequently, aortic stiffness has recently been regarded as a risk factor that needs to be treated. 7 It has also been established that aortic stiffness is increased in individuals with coronary artery disease (CAD) and in those with atherosclerosis and that it is an independent predictor of CAD. 8 In the present study, we reported that there might possibly be a relationship between the increment in aortic stiffness and left ventricular (LV) diastolic dysfunction. 9 In the current study our objective was to investigate the elastic properties of the aorta in the patients with CE and the relationship between these characteristics and LV diastolic functions. Methods Study PopulationThe cases were selected from the patients who admitted to our cardiology department for coronary angiography between the years 2001 and 2004. The study population was divided into 3 groups according to the results of the coronary angiograms. A total of 105 patients were enrolled in the present study; in the first group there were 35 patients with CE, the second group consisted of 35 patients with CAD (coronary lesion causing ≥50% luminal narrowing in at least 1 coronary artery) and the third group consisted of 35 patients with normal coronary arteries. CE was defined as localized or diffuse non-obstructive lesions of the epicardial Aortic Elastic Properties in Patients WithCoronary Artery Ectasia Nurullah Tuzun, MD; Halil Tanriverdi, MD*; Harun Evrengul, MD*; Deniz Seleci Kuru, MD*; Asim Oktay Ergene, MD** Background The purpose of the present...

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“…3,4 This pressure load is regarded as a potential mechanism of left ventricular hypertrophy 5 and to trigger cardiovascular diseases, [6][7][8] such as sudden death, 5,9 myocardial infarction 10 and stroke. 11 As BP surge and BP variability are considerably associated with baroreceptor reflex function and sympathetic nervous activation, 1,12 the degree of SLBPS may differ among patients, even when they show similar degrees of O 2 desaturation.…”

Section: Introductionmentioning

confidence: 99%

Development and clinical application of a new technique for detecting ‘sleep blood pressure surges’ in sleep apnea patients based on a variable desaturation threshold

et al. 2011

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Obstructive sleep apnea (OSA) places an enormous pressure load on the cardiovascular system by inducing a temporary blood pressure (BP) surge (sleep BP surge (SLBPS)), often resulting in target organ damage and cardiovascular events, such as left ventricular hypertrophy, sudden death, myocardial infarction and stroke. Accurate measurement of SLBPS would be valuable for the risk stratification of OSA patients. We developed a new oxygen-triggered BP monitoring system based on a variable SpO 2 threshold (VT algorithm) to selectively detect severe SLBPS, which are associated with morbidity, and evaluated its performance in comparison with a previous technique based on a fixed SpO 2 threshold (FT algorithm). In 23 OSA patients, the correlation between individual minimum SpO 2 values and SLBPS was not significant when the FT algorithm was used alone (r¼0.400, P¼0.058) but became significant (r¼0.725, Po0.0001) when the VT algorithm was additionally used. In another 13 OSA patients, when the FT algorithm was eliminated from the FT+VT algorithm, the number of BP readings was drastically reduced (36±22.7 vs. 61±55.0 times, P¼0.004) with a similar correlation between minimum SpO 2 and SLBPS. The correlation between the apnea hypopnea index and SLBPS was significant when measured with the present method, but not when assessed with ambulatory BP monitors (ABPM) simulation (r¼0.519, P¼0.001 vs. r¼0.149, P¼0.385). In conclusion, oxygen-triggered BP monitoring with a variable threshold is able to detect severe OSA-related BP surges more specifically and reduce the number of BP readings required during sleep compared with detection using a fixed threshold or the conventional ABPM method.

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Effect of Obstructive Sleep Apnea on Aortic Elastic Parameters

Cited by 30 publications

References 36 publications

Increased arterial stiffness in obstructive sleep apnea: a systematic review

Increased arterial stiffness in obstructive sleep apnea: a systematic review

Aortic Elastic Properties in Patients With Coronary Artery Ectasia

Development and clinical application of a new technique for detecting ‘sleep blood pressure surges’ in sleep apnea patients based on a variable desaturation threshold

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