2017
DOI: 10.1159/000456547
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Abstract: In children, proper growth and development are often regarded as a surrogate marker for good health. A complex system controls the initiation, rate, and cessation of growth, and thus gives a wonderful example of the interactions between genetics, epigenetics, and environmental factors (especially stress and nutrition). Malnutrition is considered a leading cause of growth attenuation in children. This review summarizes our current knowledge regarding the mechanisms linking nutrition and skeletal growth, includi… Show more

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Cited by 24 publications
(14 citation statements)
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References 172 publications
(229 reference statements)
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“…Elevated circulating IGF-I levels were absent prior to rGH therapy for 23.8% of the patients in our cohort but IGF-I levels rose markedly after initiating rGH treatment. The absence of high IGF-I levels prior to rGH therapy can be explained by the previously described feeding difficulties of some patients with IGF1R defects, which can lead to nutritional deficiency and low basal levels of IGF-I 31. This pattern of low IGF-I levels which increase rapidly after initiating rGH therapy, should alert clinicians to the possibility of an IGF1R defect in a child born SGA, especially with the presence of microcephaly.…”
Section: Discussionmentioning
confidence: 97%
“…Elevated circulating IGF-I levels were absent prior to rGH therapy for 23.8% of the patients in our cohort but IGF-I levels rose markedly after initiating rGH treatment. The absence of high IGF-I levels prior to rGH therapy can be explained by the previously described feeding difficulties of some patients with IGF1R defects, which can lead to nutritional deficiency and low basal levels of IGF-I 31. This pattern of low IGF-I levels which increase rapidly after initiating rGH therapy, should alert clinicians to the possibility of an IGF1R defect in a child born SGA, especially with the presence of microcephaly.…”
Section: Discussionmentioning
confidence: 97%
“…IGF-1 is also an important growth hormone, mediating protein anabolism and linear growth [ 27 ]. IGF-1 serum levels are responsive to improved nutritional status [ 61 ] and high-protein intake [ 48 , 62 ]. Protein restriction in children results in declined IGF-I concentrations [ 48 ].…”
Section: Discussionmentioning
confidence: 99%
“…processes (Gat-Yablonski & De Luca 2017). To resume normal growth or initiate CUG, undernourished children must regain up to 85% of their weight for height (Kay's & Hindmarsh 2006).…”
Section: Introductionmentioning
confidence: 99%