Effect of nut consumption on oxidative stress and the endothelial function in metabolic syndrome

López-Uriarte, Patricia; Nogués, Rosa; Sáez, Guillermo; Bulló, Mònica; Romeu, Marta; Masana, Luís; Tormos, Carmen; Casas‐Agustench, Patricia; Salas‐Salvadó, Jordi

doi:10.1016/j.clnu.2009.12.008

Cited by 84 publications

(69 citation statements)

References 49 publications

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“…Conversely, a smaller study using the same mixed-nut diet against a similar healthy diet without nuts for 12 weeks in patients with metabolic syndrome failed to show any between-diet differences in oxidized LDL and other oxidation biomarkers, except for reduced DNA damage with the nut diet [107]. …”

Section: Nut Feeding Trials With Outcomes On Cardiovascular Risk Fmentioning

confidence: 99%

“…Two further studies have assessed the effects of nuts on vascular reactivity [107,126]. A recent study from Turkey reported improved FMD after a diet supplemented with pistachios compared with a healthy diet, but the sequential design of the interventions precludes firm conclusions [126].…”

Section: Nut Feeding Trials With Outcomes On Cardiovascular Risk Fmentioning

confidence: 99%

“…A recent study from Turkey reported improved FMD after a diet supplemented with pistachios compared with a healthy diet, but the sequential design of the interventions precludes firm conclusions [126]. Finally, a 12-week parallel design study in patients with metabolic syndrome comparing healthy diets with or without supplementation with 30 g of mixed nuts per day found no between-diet differences in vascular reactivity, as assessed by digital pulse amplitude tonometry [107]. However, it must be noted that this is a non-standard technique to measure endothelial function with much less clinical trial experience than FMD of the brachial artery [117].…”

Section: Nut Feeding Trials With Outcomes On Cardiovascular Risk Fmentioning

confidence: 99%

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Health Benefits of Nut Consumption

2010

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Nuts (tree nuts and peanuts) are nutrient dense foods with complex matrices rich in unsaturated fatty and other bioactive compounds: high-quality vegetable protein, fiber, minerals, tocopherols, phytosterols, and phenolic compounds. By virtue of their unique composition, nuts are likely to beneficially impact health outcomes. Epidemiologic studies have associated nut consumption with a reduced incidence of coronary heart disease and gallstones in both genders and diabetes in women. Limited evidence also suggests beneficial effects on hypertension, cancer, and inflammation. Interventional studies consistently show that nut intake has a cholesterol-lowering effect, even in the context of healthy diets, and there is emerging evidence of beneficial effects on oxidative stress, inflammation, and vascular reactivity. Blood pressure, visceral adiposity and the metabolic syndrome also appear to be positively influenced by nut consumption. Thus it is clear that nuts have a beneficial impact on many cardiovascular risk factors. Contrary to expectations, epidemiologic studies and clinical trials suggest that regular nut consumption is unlikely to contribute to obesity and may even help in weight loss. Safety concerns are limited to the infrequent occurrence of nut allergy in children. In conclusion, nuts are nutrient rich foods with wide-ranging cardiovascular and metabolic benefits, which can be readily incorporated into healthy diets.

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Section: Nut Feeding Trials With Outcomes On Cardiovascular Risk Fmentioning

confidence: 99%

Section: Nut Feeding Trials With Outcomes On Cardiovascular Risk Fmentioning

confidence: 99%

Section: Nut Feeding Trials With Outcomes On Cardiovascular Risk Fmentioning

confidence: 99%

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Health Benefits of Nut Consumption

2010

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“…In spite of this, endothelial functional improvement did not reach statistical significance (74) . A quantity of 10 -30 g nuts per d consumed by participants with either CVD risk or the metabolic syndrome also demonstrated no benefits on endothelial function (48,106) . Consumption of two doses (10 and 20 % of energy) of pistachios did not lead to a reduction in endothelial function (107) despite relatively high doses of up to 126 g/d consumed for 4 weeks.…”

Section: Effects Of Nut Consumption On Endothelial Vasodilator Functionmentioning

confidence: 99%

“…† Vasodilator function measured by flow-mediated dilatation, except Ló pez-Uriarte et al (2010) (106) , measured by Endo-PAT device. ‡ Mixed nuts ¼ walnuts, almonds and hazelnuts.…”

Section: G/d Hazelnuts Vcam (A) (B) Ns Ns-i; 0·1 Vcam (C) Ns Ns-i; 0·mentioning

confidence: 99%

Nut consumption for vascular health and cognitive function

et al. 2014

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Nuts are rich in many nutrients that can benefit multiple cardiometabolic functions, including arterial compliance, blood pressure, inflammation, glucoregulation and endothelial vasodilatation. Impaired vasodilatation may contribute to impaired cognitive performance due to poor cerebral perfusion. The present narrative review examines associations between nut consumption, vascular health and cognitive function. It includes a systematic search which identified seventy-one epidemiological or intervention studies in which effects of chronic nut consumption on blood pressure, glucoregulation, endothelial vasodilator function, arterial compliance, inflammatory biomarkers and cognitive performance were evaluated. Weighted mean changes were estimated where data were available; they indicate that nut consumption reduces blood pressure and improves glucoregulation, endothelial vasodilator function and inflammation, whilst a limited number of studies suggest that nut consumption may also improve cognitive performance. Further clinical trials are warranted to explore relationships between nut consumption, endothelial function and cognitive function.

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