Effect of Nigella sativa fixed oil on the hormonal profile of androgens and circulating in male rats

Khasmi, Mohammed El; Allah, A. Issaoub; Mohamed, Fahim; Riad, Fouad; Safwate, Abdallah; Abbadi, Najia El; Tahri, El Hassane

doi:10.1007/s10298-011-0654-1

Cited by 7 publications

(4 citation statements)

References 35 publications

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“…These findings are in line with previous studies [ 30 , 53 ] that concluded that TT, LH, and FSH were dramatically enhanced by Ns seed extractions. The beneficial effects of Nigella sativa extracts are owed to the boosting functioning of the hypothalamic–pituitary–testicular axis [ 54 ]. Honey supplementation during ischemia followed by reperfusion led to increased FSH, LH, and TT levels [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Nigella sativa-Floral Honey and Multi-Floral Honey versus Nigella sativa Oil against Testicular Degeneration Rat Model: The Possible Protective Mechanisms

et al. 2023

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The male reproductive function, particularly the testes, and the related hormones are sensitive to various xenobiotics. This work aimed for the first time to assess Nigella sativa floral honey (NS floral honey) and multi-floral honey (M-floral honey) versus Nigella sativa oil (NS oil) against rat testicular degeneration induced with azathioprine (AZA). A total of 40 male Wister rats were assigned into 5 groups: (1) control, (2) 15 mg/kg of AZA, (3) AZA + 1.4 mL/kg of M-floral honey, (4) AZA + 1.4 mL/kg of NS floral honey, and (5) AZA + 500 mg/kg of NA oil. Total testosterone (TT), free testosterone (FT), free androgen index (FAI), gonadotrophins, sex-hormone-binding globulin (SHBG), apoptosis markers, and redox status were assessed to clarify the possible protective mechanisms. Pituitary–testicular axis disruption, apoptosis markers, poor redox status, and sperm quality (count, viability, and motility) were set with AZA. Serum TT, SHBG, and absolute and relative testis weight were significantly restored in the NS oil and NS floral honey groups. Meanwhile, the NS oil group exhibited a significant elevation in FT and FAI. Serum gonadotrophins increased significantly in the NS floral honey (p < 0.01) and M-floral honey and NS oil (p < 0.05) groups. Testicular caspase-3, caspase-9, and nitric oxide showed significant improvement in the NS floral honey and NS oil groups. NS oil supplementation significantly normalized redox status (p < 0.05), whereas NS floral honey improved malondialdehyde and superoxide dismutase activity. Sperm quality exhibited a significant improvement in the NS oil group (p < 0.05). M-floral honey did not show reliable results. Although NS floral honey could protect against testicular damage, it did not upgrade to the level of improvement achieved with NS oil. We claim that further clinical studies are essential for focusing on the quality and quantity of bioactive constituents.

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Section: Discussionmentioning

confidence: 99%

Nigella sativa-Floral Honey and Multi-Floral Honey versus Nigella sativa Oil against Testicular Degeneration Rat Model: The Possible Protective Mechanisms

et al. 2023

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“…In another study, the effect of Nigella sativa oil was studied on male rat, & it was found N. sativa oil extract induced a significant increase in the weight of reproductive organs, and in the circulating levels of serum FSH, LH & testosterone as compared to control animals (P< 0.05). The study concluded that the Nigella sativa fixed oil may stimulate steroidogenesis by activation of hypothalamo-pituitarytesticular axis, (22). Recently, an Iraqi study was done to investigate the effects of Nigella sativa oil on reproductive system of rat.…”

Section: Discussionmentioning

confidence: 99%

The use of Nigella sativa as a single agent in treatment of male infertility

M. Marbat,

Abid Ali,

M. Hadi

2023

Tikrit J. Pharm. Sci.

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Infertility is a condition defined by the failure of the wife to achieve a successful pregnancy after 12 months or more of regular unprotected intercourse. About 1 in 7 couples have problems conceiving, with a similar incidence worldwide. Over 80% of couples who have regular sexual intercourse and do not use contraception will achieve a pregnancy within one year. The aim of this was to investigate the effect of Nigella sativa on male infertility. This study is a case control longitudinal clinical study. It was conducted on 55 infertile men with age range from 18-40 years from December 2011 to December 2012. The patients included were those who attended the clinics of specialist urologist, who are complaining of infertility with low sperm count or quality. Forty patients from the total 55 patients (15 patients withdraw from the study for many reasons) who were complete the whole treatment trial were included in this study. 40 infertile men were treated with N. sativa Capsule 2g per day. Semen parameters, serum Follicle stimulating hormone (FSH), Luteinizing hormone (LH) and testosterone were measured before and after 3 months of treatment with N. sativa. Sperm count was significantly increased after 3 months of treatment with N. sativa. The percentage of actively moving sperms was significantly increased after 3 months of treatment with N sativa. The semen volume was significantly increased after 3 months of treatment with N sativa. The sperms viability was significantly increased after 3 months of treatment with N. sativa. Sperms normal morphology was significantly increased after 3 months of treatment with N. sativa. Serum FSH, LH and testosterone levels were significantly increased after 3 months of treatment with N. sativa. These results supported by many studies published that explained and concluded the effect of N. sativa on semen quality. The present study conclude that N. sativa can be used as a single agent for treatment of male infertility.

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“…El-Khasmi`s study showed that intraperitoneal injection of black seed oil in mice could increase the secretion of sex hormones (FSH, LH and Tes), a process that follows the activation of the hypothalamicpituitary-testicular axis, and then, LH is released leading to Tes biosynthesis (El Khasmi et al, 2011). Immature spermatozoa have a large amount of cytoplasm in the middle part of cells that is rich in the enzyme glucose-6-phosphate dehydrogenase.…”

Section: Discussionmentioning

confidence: 99%

“…Also, the study of Mohamad et al showed that oral consumption of black seed increased the germ cell population and the number of mature and immature Leydig cells and also reduced cell degeneration (Mohammad et al., 2009). El‐Khasmi`s study showed that intraperitoneal injection of black seed oil in mice could increase the secretion of sex hormones (FSH, LH and Tes), a process that follows the activation of the hypothalamic‐pituitary‐testicular axis, and then, LH is released leading to Tes biosynthesis (El Khasmi et al., 2011). Immature spermatozoa have a large amount of cytoplasm in the middle part of cells that is rich in the enzyme glucose‐6‐phosphate dehydrogenase.…”

Section: Discussionmentioning

confidence: 99%

Genetic, biochemical and histopathological evaluations of thymoquinone on male reproduction system damaged by paclitaxel in Wistar rats

et al. 2021

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One of the most critical side effects of anti-cancer drugs is disruption in spermatogenesis. Paclitaxel (PTX) is the most commonly used drug in chemotherapy for various cancers, including breast, ovarian and prostate (Semet et al., 2017). This herbal alkaloid-based drug prevents replication and metastasis of tumours through destruction of the cellular cytoskeleton (Yang & Horwitz, 2017). As testes are susceptible organs to chemotherapeutic drugs, these agents can reduce the quality of sperm chromatin with adverse effects on spermatogenesis process (Semet et al., 2017). Since the past, herbal medications have been widely used for disease treatments. Nigella sativa is a plant of the Ranunculaceae family with many medicinal applications in diseases treatment, including gastrointestinal, respiratory and renal disorders (Yimer et al., 2019). Medical properties of Nigella sativa are attributed to quinone compounds. Among these,

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Effect of Nigella sativa fixed oil on the hormonal profile of androgens and circulating in male rats

Abstract: Eff et de l'huile fi xe de la nigelle (Nigella sativa L.) sur le profi l des androgènes chez le rat mâle

Cited by 7 publications

References 35 publications

Nigella sativa-Floral Honey and Multi-Floral Honey versus Nigella sativa Oil against Testicular Degeneration Rat Model: The Possible Protective Mechanisms

Nigella sativa-Floral Honey and Multi-Floral Honey versus Nigella sativa Oil against Testicular Degeneration Rat Model: The Possible Protective Mechanisms

The use of Nigella sativa as a single agent in treatment of male infertility

Genetic, biochemical and histopathological evaluations of thymoquinone on male reproduction system damaged by paclitaxel in Wistar rats

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