Effect of nifedipine on rectoanal motility

Chrysos, Emmanuel; Xynos, Evaghelos; Tzovaras, George; Zoras, Odysseas; Tsiaoussis, John; Vassilakis, Sophocles John

doi:10.1007/bf02068078

Cited by 71 publications

(31 citation statements)

References 11 publications

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“…Used to treat hypertension, angina pectoris, Raynaud's syndrome, congestive heart failure, and cardiomyopathies, it may cause side effects like headache, upset stomach, dizziness, tiredness, flushing, heartburn, tachycardia, muscle cramps, enlargement of gum tissue around teeth, constipation, nasal congestion, and cough. The first clinical study on the effects of calcium antagonists on resting www.intechopen.com anal pressure showed that pressures were reduced with sublingual nifedipine in both healthy volunteers and patients with hypertonic sphincters (Chrysos et al, 1996). A medline database literature search concerning the non-surgical treatment of chronic anal fissures, including 282 patients, called the attention to nifedipine gel.…”

Section: Calcium Channel Blockersmentioning

confidence: 99%

Nifedipine Gel with Lidocaine in the Treatment of Anal Fissure in Children: A Pilot Study and Review of the Literature

Klin¹,

Abu-Kishk²,

Efrati³

et al. 2012

Complementary Pediatrics

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Section: Calcium Channel Blockersmentioning

confidence: 99%

Nifedipine Gel with Lidocaine in the Treatment of Anal Fissure in Children: A Pilot Study and Review of the Literature

Klin¹,

Abu-Kishk²,

Efrati³

et al. 2012

Complementary Pediatrics

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“…The first clinical study on the effects of calcium antagonists on resting anal pressure showed that pressures were reduced with sublingual nifedipine in both healthy volunteers and patients with hypertonic sphincters [58]. A small, uncontrolled study, where 20 mg of oral nifedipine retard twice daily was used to treat 15 patients with chronic anal fissure, showed 60% healing at 8 weeks [59].…”

Section: Calcium Channel Blockersmentioning

confidence: 98%

Anal fissure: the changing management of a surgical condition

Acheson

Scholefield

2003

Langenbecks Arch Surg

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Despite there being initial success with many of these pharmacological agents in the treatment of patients with chronic anal fissures, there are still some concerns about their use. In particular, the occurrence of side effects limits their use, and, unfortunately, they are not always effective at healing fissures. However, despite these drawbacks they remain excellent first-line options in the treatment of chronic anal fissures, and surgery should be offered only to patients who fail these therapies.

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“…As they observed, calcium channels are less well represented in skeletal muscle, but they are not absent; more data are needed in order to study the calcium antagonist activity (both locally and systemically administered) in the external anal sphincter.5, 6 Although we agree that further studies are required in order to use nifedipine locally in anorectal and urogenital conditions, our aim is to suggest that the topical use of nifedipine is effective because of its relaxing activity, in addition to its anti-inflammatory action 7 and modulating effect on the microcirculation. 8…”

mentioning

confidence: 88%