Effect of neurotrophic factor, MDP, on rats’ nerve regeneration

ObjectiveTo evaluate the clinical results from treating chronic peripheral nerve injuries using the superficial peroneal nerve as a graft donor source.MethodsThis was a study on eleven patients with peripheral nerve injuries in the upper limbs that were treated with grafts from the sensitive branch of the superficial peroneal nerve. The mean time interval between the dates of the injury and surgery was 93 days. The ulnar nerve was injured in eight cases and the median nerve in six. There were three cases of injury to both nerves. In the surgery, a longitudinal incision was made on the anterolateral face of the ankle, thus viewing the superficial peroneal nerve, which was located anteriorly to the extensor digitorum longus muscle. Proximally, the deep fascia between the extensor digitorum longus and the peroneal longus muscles was dissected. Next, the motor branch of the short peroneal muscle (one of the branches of the superficial peroneal nerve) was identified. The proximal limit of the sensitive branch was found at this point.ResultsThe average space between the nerve stumps was 3.8 cm. The average length of the grafts was 16.44 cm. The number of segments used was two to four cables. In evaluating the recovery of sensitivity, 27.2% evolved to S2+, 54.5% to S3 and 18.1% to S3+. Regarding motor recovery, 72.7% presented grade 4 and 27.2% grade 3. There was no motor deficit in the donor area. A sensitive deficit in the lateral dorsal region of the ankle and the dorsal region of the foot was observed. None of the patients presented complaints in relation to walking.ConclusionsUse of the superficial peroneal nerve as a graft source for treating peripheral nerve injuries is safe and provides good clinical results similar to those from other nerve graft sources.

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“…Despite decades of advances in nerve research, 12 treatment of peripheral nerve injuries continues to be a significant challenge.…”

Section: Discussionmentioning

confidence: 99%

Use of superficial peroneal nerve graft for treating peripheral nerve injuries

Ribak

Filho

Tietzmann

et al. 2016

Revista Brasileira de Ortopedia (English Edition)

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“… Ferreira et al, 2019 [ 75 ] Effect of treadmill exercise after crush injury Wistar 21 Crush injury / / At day 11 and day 21 post-surgery 11 days 21 days Fregnan et al, 2016 [ 76 ] Chitosan conduits Wistar 12 Nerve transection 5 mm 10 mm Every three weeks for 12 weeks Six weeks ? Fregnan et al, 2020 [ 77 ] Silk-based nerve conduit Wistar 36 Nerve transection 10 mm 12 mm Every 3 weeks for 24 weeks 6 weeks 12 weeks Fornazari et al, 2011 [ 78 ] Effect of neurotrophic factor Wistar 40 Nerve transection / / Weekly for 12 weeks 42 days 84 days Galtrey & Fawcett, 2007 [ 19 ] …”

Section: Table A1mentioning

confidence: 99%

The Grasping Test Revisited: A Systematic Review of Functional Recovery in Rat Models of Median Nerve Injury

et al. 2022

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The rat median nerve model is a well-established and frequently used model for peripheral nerve injury and repair. The grasping test is the gold-standard to evaluate functional recovery in this model. However, no comprehensive review exists to summarize the course of functional recovery in regard to the lesion type. According to PRISMA-guidelines, research was performed, including the databases PubMed and Web of Science. Groups were: (1) crush injury, (2) transection with end-to-end or with (3) end-to-side coaptation and (4) isogenic or acellular allogenic grafting. Total and respective number, as well as rat strain, type of nerve defect, length of isogenic or acellular allogenic allografts, time at first signs of motor recovery (FSR) and maximal recovery grasping strength (MRGS), were evaluated. In total, 47 articles met the inclusion criteria. Group I showed earliest signs of motor recovery. Slow recovery was observable in group III and in graft length above 25 mm. Isografts recovered faster compared to other grafts. The onset and course of recovery is heavily dependent from the type of nerve injury. The grasping test should be used complementary in addition to other volitional and non-volitional tests. Repetitive examinations should be planned carefully to optimize assessment of valid and reliable data.

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“…These confirmed that this procedure was effective for reconstructing the loss of a nerve segment. Recently, several studies on the possibility of using neurotrophic factors for increasing the efficacy of the nerve regeneration process have been published, although there remains no standardization regarding use of these factors (11). …”

Section: Introductionmentioning

confidence: 99%

What has changed in brachial plexus surgery?

Rezende¹,

Silva²,

Paula³

et al. 2013

Clinics

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Brachial plexus injuries, in all their severity and complexity, have been extensively studied. Although brachial plexus injuries are associated with serious and often definitive sequelae, many concepts have changed since the 1950s, when this pathological condition began to be treated more aggressively. Looking back over the last 20 years, it can be seen that the entire approach, from diagnosis to treatment, has changed significantly. Some concepts have become better established, while others have been introduced; thus, it can be said that currently, something can always be offered in terms of functional recovery, regardless of the degree of injury. Advances in microsurgical techniques have enabled improved results after neurolysis and have made it possible to perform neurotization, which has undoubtedly become the greatest differential in treating brachial plexus injuries. Improvements in imaging devices and electrical studies have allowed quick decisions that are reflected in better surgical outcomes.In this review, we intend to show the many developments in brachial plexus surgery that have significantly changed the results and have provided hope to the victims of this serious injury.

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Effect of neurotrophic factor, MDP, on rats’ nerve regeneration

Cited by 4 publications

References 15 publications

Use of superficial peroneal nerve graft for treating peripheral nerve injuries

Use of superficial peroneal nerve graft for treating peripheral nerve injuries

The Grasping Test Revisited: A Systematic Review of Functional Recovery in Rat Models of Median Nerve Injury

What has changed in brachial plexus surgery?

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