2006
DOI: 10.1001/archderm.142.12.1599
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Effect of Neonatal Phototherapy on Melanocytic Nevus Count in Children

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Cited by 47 publications
(37 citation statements)
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“…There are several studies assessing the risk of developing moles in children 8-9 years after receiving neonatal blue light phototherapy for jaundice treatment [20,21,22]. Some of these studies find an association of naevus count with phototherapy, some do not.…”
Section: Discussionmentioning
confidence: 99%
“…There are several studies assessing the risk of developing moles in children 8-9 years after receiving neonatal blue light phototherapy for jaundice treatment [20,21,22]. Some of these studies find an association of naevus count with phototherapy, some do not.…”
Section: Discussionmentioning
confidence: 99%
“…There are however potential sideeffects attributable to phototherapy, including watery diarrhea, increased insensible water loss, skin rashes, blue baby syndrome and transient bronzing of the skin. There is also controversy surrounding whether phototherapy treatment for jaundice may increase the risk of developing melanoma later in life (Matichard et al 2006;Dennery and Lorch 2007;Newman and Maisels 2007). Furthermore, the baby and mother could suffer mental and emotional pressure induced by separation when phototherapy is performed.…”
mentioning
confidence: 99%
“…Having many nevi is a recognized risk for melanoma, leading the authors to suggest that exposed children should undergo dermatologic preventive measures and surveillance for the development of melanoma. 10 Other potential derangements have previously been described, but we do not see them in daily clinical neonatal practice. For example, children who had been treated with phototherapy have increased risk for myeloid leukemia (OR = 7.5; 95%CI 1.8-31.9), 11 increased production of nitric oxide, a vasodilator involved in immunological defense mechanisms, cytotoxicity and neurotransmission, 12 and also have alterations in cytokine production, with an increase of 70% in IL-2 secretion and 56% in IL-10 production together with a reduction of 43% in the spontaneous secretion of IL-1beta.…”
Section: Phototherapymentioning
confidence: 74%