2018
DOI: 10.1016/j.foodchem.2017.07.144
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Abstract: Guabiroba fruit has been highlighted for its high phytochemical content, particularly of phenolic compounds. The stability, bioavailability, and bioactivity of these compounds can be enhanced by nanoencapsulation, to improve functionality. Poly(d,l-lactic-co-glycolic) acid (PLGA) nanoparticles containing phenolic extract of guabiroba (GPE) were synthesized by an adapted emulsion-evaporation method and their physico-chemical and functional properties were studied at two lactic to glycolic acid ratios (50:50 and… Show more

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Cited by 101 publications
(53 citation statements)
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“…However, in the ferric and molybdenum reduction assays, antioxidant activities of the water and methanol extracts were significantly (p < 0.05) greater than for the ethanol extracts. This might be due to the presence of more hydrophilic compounds in the water extracts [49].…”
Section: Ferric and Molybdenum Reductionmentioning
confidence: 99%
“…However, in the ferric and molybdenum reduction assays, antioxidant activities of the water and methanol extracts were significantly (p < 0.05) greater than for the ethanol extracts. This might be due to the presence of more hydrophilic compounds in the water extracts [49].…”
Section: Ferric and Molybdenum Reductionmentioning
confidence: 99%
“…Moreover, it has been described that the chemical structure of mangiferin creates a xanthone framework made up of four phenolic units and a glucose moiety [27]. Hence, it may be assumed that mangiferin might exhibit high affinity by PLGA and PVA forming a long structure that occurs for interaction of OH groups in the chemical composition [28]. In addition, the phenolic and glucose units present in mangiferin can efficiently stabilize the formed nanoparticle.…”
Section: Mangiferin Release Profilementioning
confidence: 99%
“…PLGA NP are internalized by cells partly through pinocytosis and also through clathrin-mediated endocytosis and enter the cytoplasm within 10 min of incubation [107]. The controlled release, biocompatibility, and biodegradability properties of PLGA NP have produced an overall decrease in cytotoxicity; therefore, they have been used as delivery systems for polyphenols rich-materials from fruit and other nutraceuticals [108][109][110][111]. The negative surface charges of PLGA could also be modified by PEGylation of the polymer [112] or coating NP with chitosan [113].…”
Section: Poly(lactic-co-glycolic Acid) Nanoparticlesmentioning
confidence: 99%