Effect of nanoemulsion modification with chitosan and sodium alginate on the topical delivery and efficacy of the cytotoxic agent piplartine in 2D and 3D skin cancer models

Giacone, Daniela V; Dartora, Vanessa Franco Carvalho; Matos, Jenyffer K.R. de; Passos, Julia Sapienza; Miranda, Daniel A.G.; Oliveira, Érica Aparecida de; Silveira, Edilberto R.; Costa-Lotufo, Letı́cia V.; Maria-Engler, Silvya Stuchi; Lopes, Luciana B.

doi:10.1016/j.ijbiomac.2020.09.167

Cited by 32 publications

(18 citation statements)

References 72 publications

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“…Piper longum L. is an important and common ingredient in Ayurvedic medicine, which has various biological activities, such as cardiovascular activities, anti-inflammatory activity, anti-tumor activity [ 24 , 25 ]. Piplartine is one of the main bioactive components found in Piper longum L. Recent studies indicated that piplartine has anti-cancer activities in several types of cancers, including glioblastoma [ 17 ], colon cancer [ 26 ], skin cancer [ 27 ], leukemia [ 28 ], hepatocellular carcinoma [ 29 ]. In addition, piplartine also exhibits antiparasitic activity [ 30 , 31 , 32 , 33 ]; however, the effect of piplartine on immunoregulation has not been well investigated.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Piplartine against LPS-Induced Sepsis through Attenuating the MAPKs/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation

et al. 2021

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Piplartine (or Piperlongumine) is a natural alkaloid isolated from Piper longum L., which has been proposed to exhibit various biological properties such as anti-inflammatory effects; however, the effect of piplartine on sepsis has not been examined. This study was performed to examine the anti-inflammatory activities of piplartine in vitro, ex vivo and in vivo using murine J774A.1 macrophage cell line, peritoneal macrophages, bone marrow-derived macrophages and an animal sepsis model. The results demonstrated that piplartine suppresses iNOS and COX-2 expression, reduces PGE2, TNF-α and IL-6 production, decreases the phosphorylation of MAPKs and NF-κB and attenuates NF-κB activity by LPS-activated macrophages. Piplartine also inhibits IL-1β production and suppresses NLRP3 inflammasome activation by LPS/ATP- and LPS/nigericin-activated macrophages. Moreover, piplartine reduces the production of nitric oxide (NO) and TNF-α, IL-6 and IL-1β, decreases LPS-induced tissue damage, attenuates infiltration of inflammatory cells and enhances the survival rate. Collectively, these results demonstrate piplartine exhibits anti-inflammatory activities in LPS-induced inflammation and sepsis and suggest that piplartine might have benefits for sepsis treatment.

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Section: Discussionmentioning

confidence: 99%

Protective Effect of Piplartine against LPS-Induced Sepsis through Attenuating the MAPKs/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation

et al. 2021

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“…Due to the encapsulation, there was a 2.8-fold reduction in the drug IC50 against melanoma cells. The developed formulation exhibited marked epidermis destruction in a 3D melanoma model, demonstrating efficacy [109]. The role of nanoemulsions is being explored as Nanoemulgels, development of nanoemulsions for polychemotherapy, as vaccine carriers and as theranostic agents.…”

Section: (Iii) Transferosomesmentioning

confidence: 99%

Skin cancer therapeutics: nano-drug delivery vectors—present and beyond

et al. 2021

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Background Skin cancers are among the widely prevalent forms of cancer worldwide. The increasing industrialization and accompanied environmental changes have further worsened the skin cancer statistics. The stern topical barrier although difficult to breach is a little compromised in pathologies like skin cancer. The therapeutic management of skin cancers has moved beyond chemotherapy and surgery. Main body of the abstract The quest for a magic bullet still prevails, but topical drug delivery has emerged as a perfect modality for localized self-application with minimal systemic ingress for the management of skin cancers. Advances in topical drug delivery as evidenced by the exploration of nanocarriers and newer technologies like microneedle-assisted/mediated therapeutics have revolutionized the paradigms of topical treatment. The engineered nanovectors have not only been given the liberty to experiment with a wide-array of drug carriers with very distinguishing characteristics but also endowed them with target specificity. The biologicals like nucleic acid-based approaches or skin penetrating peptide vectors are another promising area of skin cancer therapeutics which has demonstrated potential in research studies. In this review, a panoramic view is presented on the etiology, therapeutic options, and emerging drug delivery modalities for skin cancer. Short conclusion Nanocarriers have presented innumerable opportunities for interventions in skin cancer therapeutics. Challenge persists for the bench to bedside translation of these highly potential upcoming therapeutic strategies. Graphic abstract

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“…The excess organic solvent used, the complexity of the washing process, and the amount of time this method takes is its main drawback [3,44]. Chitosan nanoparticles prepared using the inotropic gelation method depend upon electrostatic interaction between the amino group of chitosan and the polyanions group such as triphosphate in an aqueous medium [45][46][47][48]. Firstly, the chitosan is dissolved in acetic acid in the presence of stabilizers such as poloxamer.…”

Section: Chitosan-based Nanoparticlesmentioning

confidence: 99%

A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

et al. 2020

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Biodegradable natural polymers have been investigated extensively as the best choice for encapsulation and delivery of drugs. The research has attracted remarkable attention in the pharmaceutical industry. The shortcomings of conventional dosage systems, along with modified and targeted drug delivery methods, are addressed by using polymers with improved bioavailability, biocompatibility, and lower toxicity. Therefore, nanomedicines are now considered to be an innovative type of medication. This review critically examines the use of natural biodegradable polymers and their drug delivery systems for local or targeted and controlled/sustained drug release against fatal diseases.

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Effect of nanoemulsion modification with chitosan and sodium alginate on the topical delivery and efficacy of the cytotoxic agent piplartine in 2D and 3D skin cancer models

Cited by 32 publications

References 72 publications

Protective Effect of Piplartine against LPS-Induced Sepsis through Attenuating the MAPKs/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation

Protective Effect of Piplartine against LPS-Induced Sepsis through Attenuating the MAPKs/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation

Skin cancer therapeutics: nano-drug delivery vectors—present and beyond

A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

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