Effect of nanodiamond powders on the viability and production of reactive oxygen and nitrogen species by human endothelial cells

Solarska, K.; Gajewska, Agnieszka; Kaczorowski, W.; Bartosz, Grzegorz; Mitura, Katarzyna

doi:10.1016/j.diamond.2011.10.020

Cited by 39 publications

(33 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The same nanoparticle can be captured via various mechanisms. For example, diamond powder particle uptake is based on macropinocytosis or on clathrinmediated endocytosis pathways and uptake type affects intracellular metabolism [5]. Additionally, physicochemical parameters (coating, charge) of QDs may discriminate NPs uptake type [24].…”

Section: Exposure Routes Cellular Uptake and Toxicological Effectsmentioning

confidence: 99%

“…Toxicological effects of nanoparticles on the cell structure are caused by their indirect or direct interactions with cellular organic molecules [5,38]. The major mechanism underlining NPs-mediated macromolecule toxicity is the disruption of intracellular redox homeostasis which in turn leads to oxidative damage of macromolecules such as lipids, proteins and nucleic acids [38][39][40].…”

Section: Interactions Between Nanoparticles and Organic Macromoleculesmentioning

confidence: 99%

“…Here, we resume current information on negative effects of NPs especially including their toxicity (Figure 1) [5][6][7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nanoparticle Technology as a Double-Edged Sword: Cytotoxic, Genotoxic and Epigenetic Effects on Living Cells

Jennifer¹,

Wnuk²

2013

JBNB

View full text Add to dashboard Cite

Nanoparticles are considered as powerful tools in nanotechnological applications. Due to their unique physicochemical properties, their interactions with different biological systems have been shown. Nanomaterials have been successfully used as coating materials or treatment and diagnosis tools. Nevertheless, toxic effects of nanoparticles in vitro and in vivo have also been reported. Here, we summarize the current state of knowledge on exposure routes, cellular uptake and toxicological activities of the commonly used nanoparticles. In this context, we discuss the mechanisms of toxicity of nanoparticles involving perturbation of redox milieu homeostasis and cellular signaling pathways.

show abstract

Section: Exposure Routes Cellular Uptake and Toxicological Effectsmentioning

confidence: 99%

Section: Interactions Between Nanoparticles and Organic Macromoleculesmentioning

confidence: 99%

See 1 more Smart Citation

Nanoparticle Technology as a Double-Edged Sword: Cytotoxic, Genotoxic and Epigenetic Effects on Living Cells

Jennifer¹,

Wnuk²

2013

JBNB

View full text Add to dashboard Cite

show abstract

“…42,43 It might be attributed to their chemical stability, biostability, and appropriate mechanical characteristics. 44 Toxicity of nanoparticles is affected by surface physicochemical properties such as size, morphology, hydrophobicity, and charge. 45 The ND-COOH in the present study was a negatively charged, hydrophilic, and highly functionalized nanoparticle.…”

mentioning

confidence: 99%

Comprehensive evaluation of carboxylated nanodiamond as a topical drug delivery system

Lim¹,

Kim²,

Kang³

et al. 2016

IJN

View full text Add to dashboard Cite

The best strategy in the development of topical drug delivery systems may be to facilitate the permeation of drugs without any harmful effects, while staying on the skin surface and maintaining stability of the system. Nanodiamonds (NDs) play a key role with their excellent physicochemical properties, including high biocompatibility, physical adsorption, reactive oxygen species (ROS) scavenging capability, and photostabilizing activity. Z -average sizes of carboxylated ND (ND–COOH) agglutinate decreased significantly as the pH increased. Fluorescein-conjugated ND was observed only on the stratum corneum, and no sample diffused into the dermal layer even after 48 hours. Moreover, ND–COOH and ND–COOH/eugenol complex did not show significant toxic effects on murine macrophage cells. ND improved in vitro skin permeation >50% acting as a “drug reservoir” to maintain a high drug concentration in the donor chamber, which was supported by quartz crystal microbalance results. Moreover, ND–COOH could adsorb a drug amount equivalent to 80% of its own weight. A photostability study showed that ND–COOH increased the photostability ~47% with regard to rate constant of the eugenol itself. A significant decrease in ROS was observed in the ND–COOH and ND–COOH/eugenol complex compared with the negative control during intracellular ROS assay. Moreover, ROS and cupric reducing antioxidant capacity evaluation showed that ND–COOH had synergistic effects of antioxidation with eugenol. Therefore, ND–COOH could be used as an excellent topical drug delivery system with improved permeability, higher stability, and minimized safety issue.

show abstract

“…However, for the last few years the number of publications related to this topic has been increasing and included results proving that this type of powders may find their future in biomedical applications [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

CVD carbon powders modified by ball milling

Kaźmierczak

Kaczorowski

Niedzielski

2015

Materials Science-Poland

View full text Add to dashboard Cite

Carbon powders produced using a plasma assisted chemical vapor deposition (CVD) methods are an interesting subject of research. One of the most interesting methods of synthesizing these powders is using radio frequency plasma. This method, originally used in deposition of carbon films containing different sp 2 /sp 3 ratios, also makes possible to produce carbon structures in the form of powder. Results of research related to the mechanical modification of these powders have been presented. The powders were modified using a planetary ball mill with varying parameters, such as milling speed, time, ball/powder mass ratio and additional liquids. Changes in morphology and particle sizes were measured using scanning electron microscopy and dynamic light scattering. Phase composition was analyzed using Raman spectroscopy. The influence of individual parameters on the modification outcome was estimated using statistical method. The research proved that the size of obtained powders is mostly influenced by the milling speed and the amount of balls. Powders tend to form conglomerates sized up to hundreds of micrometers. Additionally, it is possible to obtain nanopowders with the size around 100 nm. Furthermore, application of additional liquid, i.e. water in the process reduces the graphitization of the powder, which takes place during dry milling.

show abstract

Effect of nanodiamond powders on the viability and production of reactive oxygen and nitrogen species by human endothelial cells

Cited by 39 publications

References 18 publications

Nanoparticle Technology as a Double-Edged Sword: Cytotoxic, Genotoxic and Epigenetic Effects on Living Cells

Nanoparticle Technology as a Double-Edged Sword: Cytotoxic, Genotoxic and Epigenetic Effects on Living Cells

Comprehensive evaluation of carboxylated nanodiamond as a topical drug delivery system

CVD carbon powders modified by ball milling

Contact Info

Product

Resources

About