Effect of molecular weight of chitosan and its oligosaccharides on antitumor activities of chitosan-selenium nanoparticles

Preparation and characterisation of PHT-loaded chitosan lecithin nanoparticles for intranasal drug delivery to the brain

“…18 Low molecular weight chitosan was used in this study, which has been reported to have a higher aqueous solubility, and short polymer chains that contributes to forming smaller particles compared to medium and high molecular weight chitosan. 25,33,34 The pH values of prepared NP suspensions were between 4.5 and 5.0, which is compatible with the biological pH of nasal mucous, and in agreement with previous study. 32 In the present study, the ADS and zeta potentials of the prepared NPs were highly dependent on the amount of chitosan used.…”

Using of Nano - Selenium in Reducing the Negative Effects of High Temperature Stress on Chrysanthemum morifolium Ramat.

“…On the other hand, nano -selenium (nano-Se) or selenium nanoparticles (Se-NPs) has also distinguished features including low toxicity and high bioactivity comparing with other Se-forms like selenate or selenite or selenomethionine (Djanaguiraman et al, 2018). In human and animal health, many applications have been reported also for nano-selenium including the nano-medicine and therapeutic applications (Chaudhary et al, 2016;Zhao et al, 2017;Hosnedlova et al, 2018;Khurana et al, 2019 andSong et al, 2020). Nano-Se has the ability to alleviate the stressful conditions on many cultivated plants such as heavy metal stress on rice (Hussain et al, 2020), NaCl stress on the growth and fruit quality of tomato (Morales-Espinoza et al, 2019), salinity stress on the yield of strawberry (Zahedi et al, 2019a), high-temperature stress on sorghum grains (Djanaguiraman et al, 2018), and disease stress on tomato (Quiterio-Gutiérrez et al, 2019).…”

Molar mass effect in food and health

“…Recently, Se containing nanoparticles have been actively studied to improve the bioavailability by stabilising Se by polysaccharides, chitosan, curdlan, and mushroom polysaccharides ( Song et al, 2020 ). Chitosan (CH or CS), a cationic polysaccharide widely found in the exoskeleton of crustaceans, insects and fungi, was proved to be effective to stabilise selenium nano particles (SeNPs) ( Song et al, 2020 ; Zhang et al, 2015 ).…”

“…Recently, Se containing nanoparticles have been actively studied to improve the bioavailability by stabilising Se by polysaccharides, chitosan, curdlan, and mushroom polysaccharides ( Song et al, 2020 ). Chitosan (CH or CS), a cationic polysaccharide widely found in the exoskeleton of crustaceans, insects and fungi, was proved to be effective to stabilise selenium nano particles (SeNPs) ( Song et al, 2020 ; Zhang et al, 2015 ). Zhang et al (2015) prepared CS (<3 kDa)-Se 0 NPs and CS(200 kDa)-Se 0 NPs, and examined the release of Se from the nanoparticles in different environments, pH 1.2 with pepsin, pH 7.4 with pancreatin, simulated sweat, and in free radical systems.…”

“… Song et al (2020) stabilised Se 0 NPs (Se 0 stands for the element Se with zero oxidation state) using CS with three different molar masses, 3 k, 65 k, and 600 k Da. They examined the anti-tumour activities of CS stabilised Se 0 NPs, CS (3 k)-Se 0 NPs, CS (65 k)-Se 0 NPs, and CS (600 k)-Se 0 NPs both in vitro and in vivo .…”