Effect of molecular weight of poly(ethylene glycol) as humectant in interpenetrating polymer network hydrogels based on poly(sodium AMPS) and gelatin for wound dressing applications

Kapanya, Apichaya; Somsunan, Runglawan; Phasayavan, Witchaya; Molloy, Robert; Jiranusornkul, Supat

doi:10.1080/00914037.2020.1740983

Cited by 9 publications

(6 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Generally, the amount of bound water depends on the hydrophilic group contents in the hydrogel network . Hence, water molecules that interact with the acrylamide and sulfonate groups (hydrophilic group) of Na-AMPS are the most tightly bound and therefore tend to be nonfreezable water . It is evident that the normal P(Na-AMPS) hydrogel is nonfreezable and higher than the PCLDA-introduced P(Na-AMPS) hydrogel, indicating that it is strongly affected by the hydrophobicity of the polymer network.…”

Section: Resultssupporting

confidence: 89%

“…These observations corroborate the states of water and water retention results. A previous study had reported that larger pore sizes indicate more free and loosely bound water, while smaller pore sizes indicate more tightly bound water in the hydrogel . The decreasing pore size of the hydrogel implies that more water molecules remain in the hydrogel.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis of Poly(ε-caprolactone) Diacrylate for Micelle-Cross-Linked Sodium AMPS Hydrogel for Use as Controlled Drug Delivery Wound Dressing

et al. 2021

Self Cite

View full text Add to dashboard Cite

This study focuses on the synthesis of poly(ε-caprolactone) diacrylate (PCLDA) for the fabrication of micelle-cross-linked sodium AMPS wound dressing hydrogels. The novel synthetic approach of PCLDA is functionalizing a PCL diol with acrylic acid. The influences of varying the PCL diol/AA molar ratio and temperature on the suitable conditions for the synthesis of PCLDA are discussed. The hydrogel was synthesized through micellar copolymerization of sodium 2-acrylamido-2-methylpropane sulfonate (Na-AMPS) as a basic monomer and PCLDA as a hydrophobic association monomer. In this study, an attempt was made to develop new hydrogel wound dressings meant for the release of antibacterial drugs (ciprofloxacin and silver sulfadiazine). The chemical structures, morphology, porosity, and water interaction of the hydrogels were characterized. The hydrogels’ swelling ratio and water vapor transmission rate (WVTR) showed a high swelling capacity (4688–10753%) and good WVTR (approximately 2000 g·m–2·day–1), which can be controlled through variation of the PCLDA concentration. The mechanical property results confirmed that PCLDA improved the mechanical properties of the hydrogel; the stress increased from 37 to 68 kPa, and the strain increased from 198 to 360% with increasing PCLDA (0–30% wt of Na-AMPS). These hydrogels presented no cytotoxicity based on over 70% cell viability responses (L929 fibroblasts) using an in vitro 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Additionally, the drug release mechanism, kinetic models, and antibacterial activity were determined. The results demonstrated that antibiotics were released from the hydrogel with a Fickian diffusion mechanism and antibacterial activity against Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and Gram-positive bacteria (Staphylococcus aureus). Based on the results obtained, and bearing in mind that further progress still needs to be made, the fabricated hydrogels show considerable potential for meeting the stringent property requirements of hydrogel wound dressings.

show abstract

Section: Resultssupporting

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Synthesis of Poly(ε-caprolactone) Diacrylate for Micelle-Cross-Linked Sodium AMPS Hydrogel for Use as Controlled Drug Delivery Wound Dressing

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Chitosan-based thermoresponsive hydrogels loaded with piscidin-1 demonstrated excellent bactericidal activity against drug-resistant pathogens while maintaining biocompatibility. , Liposomal encapsulation protected the antimicrobial activity of IK8, and PEG-based hydrogels with lipid-coated gold nanorods enabled light-activated release and enhanced bactericidal activity. pH-sensitive hydrogels made from dextran and pH-sensitive peptides released AMPs in response to the weakly acidic wound environment, promoting wound healing and reducing bacterial load. , DNA hydrogels displayed controlled AMP release in response to enzymatic degradation, showing promise in treating cutaneous S. aureus infections and accelerating wound healing. Additionally, injectable hydrogels using cyclic peptide linkers and modified HA released AMPs in the presence of MMP and ROS, efficiently treating infected diabetic wounds.…”

Section: Different Biomaterial-based Approaches In Transdermal Delive...mentioning

confidence: 99%

“…pH-sensitive hydrogels made from dextran and pH-sensitive peptides released AMPs in response to the weakly acidic wound environment, promoting wound healing and reducing bacterial load. 150,151 DNA hydrogels displayed controlled AMP release in response to enzymatic degradation, showing promise in treating cutaneous S. aureus infections and accelerating wound healing. Additionally, injectable hydrogels using cyclic peptide linkers and modified HA released AMPs in the presence of MMP and ROS, efficiently treating infected diabetic wounds.…”

Section: Different Biomaterial-based Approaches In Transdermal Delive...mentioning

confidence: 99%

Advances in Transdermal Delivery of Antimicrobial Peptides for Wound Management: Biomaterial-Based Approaches and Future Perspectives

Firdous,

Sagor,

Arafat

2023

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

Antimicrobial peptides (AMPs), distinguished by their cationic and amphiphilic nature, represent a critical frontier in the battle against antimicrobial resistance due to their potent antimicrobial activity and a broad spectrum of action. However, the clinical translation of AMPs faces hurdles, including their susceptibility to degradation, limited bioavailability, and the need for targeted delivery. Transdermal delivery has immense potential for optimizing AMP administration for wound management. Leveraging the skin's accessibility and barrier properties, transdermal delivery offers a noninvasive approach that can circumvent systemic side effects and ensure sustained release. Biomaterialbased delivery systems, encompassing nanofibers, hydrogels, nanoparticles, and liposomes, have emerged as key players in enhancing the efficacy of transdermal AMP delivery. These biomaterial carriers not only shield AMPs from enzymatic degradation but also provide controlled release mechanisms, thereby elevating stability and bioavailability. The synergistic interaction between the transdermal approach and biomaterial-facilitated formulations presents a promising strategy to overcome the multifaceted challenges associated with AMP delivery. Integrating advanced technologies and personalized medicine, this convergence allows the reimagining of wound care. This review amalgamates insights to propose a pathway where AMPs, transdermal delivery, and biomaterial innovation harmonize for effective wound management.

show abstract

“…On the one hand, the excellent swelling property can quickly absorb blood and exudate from the wound to keep the wound clean. On the other hand, the proper swelling ability can keep the wound moist and promote wound healing [26].…”

Section: Inflationary Behaviormentioning

confidence: 99%

Multifunctional Gel Films of Marine Polysaccharides Cross-Linked with Poly-Metal Ions for Wound Healing

et al. 2022

View full text Add to dashboard Cite

The development of an efficient and convenient material to improve skin tissue regeneration is a major challenge in healthcare. Inspired by the theory of moist wound healing, portable chitooligosaccharide (COS)/sodium alginate (SA) dual-net gel films containing multiple metal ions were prepared by a casting and in -situ spray method, which can be used to significantly promote wound healing without the use of therapeutic drugs. A variety of divalent cations was introduced in this experiment to improve the advantages of each metal ion by forming metal ion chelates with COS. Moreover, the physicochemical properties and antioxidant properties of nIon2+-COS/SA gel films were systematically characterized and evaluated by in vitro experiments. The gel films showed good antibacterial activity against Gram-negative and Gram-positive bacteria. In addition, the gel films showed good cytocompatibility in cellular experiments, and the gel films with Zn2+ and Sr2+ addition significantly accelerated wound healing in whole skin defect model experiments. Therefore, this nIon2+-COS/SA gel film is an ideal candidate material for wound dressing.

show abstract

Effect of molecular weight of poly(ethylene glycol) as humectant in interpenetrating polymer network hydrogels based on poly(sodium AMPS) and gelatin for wound dressing applications

Cited by 9 publications

References 30 publications

Synthesis of Poly(ε-caprolactone) Diacrylate for Micelle-Cross-Linked Sodium AMPS Hydrogel for Use as Controlled Drug Delivery Wound Dressing

Synthesis of Poly(ε-caprolactone) Diacrylate for Micelle-Cross-Linked Sodium AMPS Hydrogel for Use as Controlled Drug Delivery Wound Dressing

Advances in Transdermal Delivery of Antimicrobial Peptides for Wound Management: Biomaterial-Based Approaches and Future Perspectives

Multifunctional Gel Films of Marine Polysaccharides Cross-Linked with Poly-Metal Ions for Wound Healing

Contact Info

Product

Resources

About