Effect of Microchannel Geometry on High‐Pressure Dispersion and Emulsification

Gothsch, T.; Finke, Jan Henrik; Beinert, S.; Lesche, C.; Schur, Julia; Büttgenbach, S.; Müller‐Goymann, Christel C.; Kwade, Arno

doi:10.1002/ceat.201000421

Cited by 49 publications

(26 citation statements)

References 12 publications

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“…17,23 Further, there are also experimental studies on nanoemulsion which do not use any theoretical prediction and fit their droplet size data using empirical power law correlations. 19,[37][38][39][40] For instance, experimental studies have shown that nanoemulsion size increases with increase in droplet viscosity (m d ) and decreases with increase in continuous phase viscosity (m c ). 29,37,40 Hence, this article focuses on bridging the gap between experimental observations and theoretical predictions for nanoemulsion droplet size.…”

Section: Introductionmentioning

confidence: 99%

Controlling and predicting droplet size of nanoemulsions: scaling relations with experimental validation

et al. 2016

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a Nanoemulsions possess powerful nano-scale properties that make them attractive for diverse applications such as drug delivery, food supplements, nanoparticle synthesis and pharmaceutical formulation. However, there is little knowledge in nanoemulsion literature about controlling and predicting droplet size. In this article, we propose a scaling relation to predict the dependence of nanoemulsion droplet size with physical properties such as viscosity of the droplet phase and continuous phase, and process parameters such as input power density. We validate our proposed scaling with a wide range of droplet size data from nanoemulsions prepared with high pressure homogenization and ultrasonication. Our proposed scaling also compares favorably with experimental data from literature. The scaling relation can serve as a guiding principle for rational design of nanoemulsions.

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Section: Introductionmentioning

confidence: 99%

Controlling and predicting droplet size of nanoemulsions: scaling relations with experimental validation

et al. 2016

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“…In addition to its hardness, stainless steel offers a good biocompatibility for pharmaceutical applications. More details concerning the developed designs and the investigations on the dispersion effect are reported by Gothsch et al (2011).…”

Section: Dispersion Micromodulementioning

confidence: 99%

Novel 3D manufacturing method combining microelectrial discharge machining and electrochemical polishing

2012

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This paper reports on the potential of microelectrical discharge machining (lEDM) as an innovative method for the fabrication of 3D microdevices. To demonstrate the wide capabilities of lEDM two different microsystems-a microfluidic device for the dispersion of nanoparticles and a star probe for microcoordinate metrology-are presented. To gain optimized process conditions as well as a high surface quality an adequate adaption of the single erosion parameters such as energy, pulse frequency and spark gap has to be carried out and is discussed below. Thus, a surface roughness of R a = 80 nm is achieved at the channel bottom. The fabricated stylus elements for the star probe have sphere diameters of 40-200 lm. For further surface quality enhancement a subsequent electrochemical polishing step is investigated. In case of the dispersion micromodule a combined process chain of lEDM-milling and electropolishing has reached a surface improvement above 70%.

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“…Several works [8][9][10][11] were performed to estimate the flow uniformity in a single microchannel plate based on mathematical models or numerical simulation. With respect to mathematical models, Commenge et al [10] investigated the features of fluid flow through microchannel reactors by an approximate pressure drop model.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Velocity Uniformity in a Single Microchannel Plate with Rectangular Manifolds at Different Entrance Velocities

2013

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The velocity distribution among microchannels with rectangular manifolds at different entrance velocities and the influences of structural parameters and entrance velocity on flow uniformity are investigated. The flow uniformity of a microchannel plate with rectangular manifold decreases with higher entrance velocity. At relatively low entrance velocity, the velocity distribution of the microchannel plate with centrosymmetric manifold is approximately symmetric. The velocity distribution becomes monotonically increased in a plate with large inlet manifold, whereas it becomes monotonically decreased in the one with large outlet manifold. A relatively uniform flow distribution can be obtained by the following conditions: longer microchannel, smaller microchannel width, symmetric manifold structure, larger manifold area, and perpendicular direction of inlet/outlet to the microchannel plane.

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Effect of Microchannel Geometry on High‐Pressure Dispersion and Emulsification

Cited by 49 publications

References 12 publications

Controlling and predicting droplet size of nanoemulsions: scaling relations with experimental validation

Controlling and predicting droplet size of nanoemulsions: scaling relations with experimental validation

Novel 3D manufacturing method combining microelectrial discharge machining and electrochemical polishing

Analysis of Velocity Uniformity in a Single Microchannel Plate with Rectangular Manifolds at Different Entrance Velocities

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