Journal of Chromatography A 2012 DOI: 10.1016/j.chroma.2011.10.087 View full text
Michael J. Gray, Sohail Jahani, Gary K.-C. Low

Abstract: This paper explores the changes in the electrospray signal response of 39 structurally different compounds caused by the quality of the methanol, when used as a component in a gradient elution mobile phase. When three batches of LC-MS grade methanol from one manufacturer were evaluated, the largest variation in the electrospray signal responses of the 39 compounds examined was 18%. However, significant enhancement of the electrospray signals of up to 106% were observed among different brands of LC-MS grade met…

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