Effect of methanol intoxication on spcific immune functions of albino rats

Parthasarathy, Narayanaperumal Jeya; Srikumar, Ramakrishnan; Manikandan, S.; Narayanan, Govindarajulu Sathya; Devi, Rathinasamy Sheela

doi:10.1007/s10565-006-0151-8

Cited by 14 publications

(11 citation statements)

References 51 publications

(44 reference statements)

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“…70 The results of present study seem to suggest that the aspartame metabolite methanol or formaldehyde may be involved in inducing oxidative stress in serum and in changes of cytokine secretion where Th1 cytokines are down-regulated and Th2 cytokines are upregulated, which may alter cell and humoral immunity. This report is strengthened by previous published studies by Parthasarathy et al, 71 where methanol intoxication alters immune function.…”

Section: Discussionsupporting

confidence: 74%

Longer period of oral administration of aspartame on cytokine response in Wistar albino rats

Choudhary

Devi

2015

Endocrinología y Nutrición

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Section: Discussionsupporting

confidence: 74%

Longer period of oral administration of aspartame on cytokine response in Wistar albino rats

Choudhary

Devi

2015

Endocrinología y Nutrición

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“…The prediction of the potential immunotoxic effects of the aspartame metabolite methanol based on in vitro studies with thymocytes (Oyama et al 2002, Nakao et al 2003) is highly speculative Although in subsequent in vivo studies by Parthasarathy et al (2006Parthasarathy et al ( , 2007 effects of the aspartame metabolite methanol on organs/tissues/cells and function of the immune system were described, these observations are considered more likely to result from an indirect stress-effect due to the high methanol levels used, in addition these high dose levels are not considered relevant for aspartame exposure. In addition, the quality of the studies was poor.…”

Section: Resultsmentioning

confidence: 99%

“…The study not considered relevant for evaluation of possible immunotoxicity of aspartame and its quality is poor. Parthasarathy et al (2006Parthasarathy et al ( , 2007 studied the in vivo effects of methanol, a known metabolite of aspartame in male rats at levels of 2.37 g/kg bw/day administered intraperitoneally for 1, 15 and 30 days (minimal lethal dose of methanol is 9.5 g/kg bw/day in rats). In their first study (2006) they reported that methanol intoxication resulted in effects on the antioxidant status, lipid peroxidation and DNA integrity in the hypothalamic-pituitary-adrenal axis.…”

Section: The Authors Concluded That Formaldehyde From Concentrations mentioning

confidence: 99%

“…In the second study of Parthasarathy et al (2007) the in vivo effects of methanol intoxication were studied using the same exposure protocol as used in the first study (2006). On day 15 and day 30 significant decreases in lymphoid organ weight ratio's, lymphoid cell counts, footpath thickness (DTH), antibody titers (in their first study of 2006 the antibody titers were increased), several cytokines and several lymphocyte subsets (T and B cells) were observed.…”

Section: The Authors Concluded That Formaldehyde From Concentrations mentioning

confidence: 99%

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Report of the meeting on Aspartame with National Experts

2010

EFSA Supporting Publications

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DISCLAIMER The present report is published complying with the transparency principle to which the European Food Safety Authority (EFSA) is subject. The conclusions and recommendations of this report reflect those of the national experts involved in the meetings 2The conclusions and recommendations of this report reflect those of the national experts involved in the meetings on aspartame and do not necessarily represent the views of EFSA. SUMMARYThe Advisory Forum of EFSA discussed the issue of aspartame in 2007 and at the 24th AF meeting held on 6-7 December 2007 it was agreed that a special meeting would be held on aspartame. This meeting of National Experts was to take place early in 2009 and, as provided in the Terms of Reference endorsed by the Advisory Forum, was to review the information available on aspartame; agree on the completeness of the information ensuring any missing data was added; identify possible data gaps and discrepancies in the available data and where such exist to consider detailed options to address the outstanding issues.An Organising Team, nominated by members of the Advisory Forum, was tasked with preparing for the meetings of National Experts by identifying, collating and reviewing all published papers on aspartame since the review carried out by the Scientific Committee on Food in 2002. In addition the Organising Team also considered available non-peer reviewed information and anecdotal claims by individuals who attributed various symptoms and illnesses directly to aspartame consumption. A meeting was held with interested parties who had submitted information in response to a ‗call for data' published by EFSA in September, 2008.Each of the areas considered, including exposure data, brain function, satiation and appetite, allergenicity and immunotoxicity, metabolic aspects and diabetes, carcinogenicity (including cancer epidemiology) and genotoxicity were considered by the Organising Team and reported on. For each, consistent with the Terms of Reference for the National Expert Meeting, they made preliminary conclusions on whether there were data gaps or discrepancies which required further consideration. This report represents the results of these deliberations.Overall, the Organising Team did not identify any major gaps in information on aspartame and the National Experts agreed with their view. However, several suggestions are made within this report for additional data which would add to the available knowledge on aspartame and its metabolites. To address the communications element of the Terms of Reference a workshop with stakeholders and other interested parties is to be arranged to share and discuss the findings of the work.In conclusion, the National Experts have not identified any new evidence that requires a recommendation to EFSA that the previous Opinions of EFSA and the SCF need to be reconsidered. 3The conclusions and recommendations of this report reflect those of the national experts involved in the meetings on aspartame and do not necessarily represent the views of EF...

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“…MeOH has been recognized as an important neurotoxicant in humans in which its toxicity is manifested at lower doses than ethanol (Sandhir and Kaur, 2006). MeOH is widely used in manufacturing, biological research, household and cleaning business and undergoes one of the highest releases to the environment based on its mixability with water and organic fluid (Mellerick and Liu, 2004; Parthasarathy et al, 2007). Methanol is biologically produced during the hydrolysis ofmethyl esters, fermentation and the combustion of green plants; it generates very reactive formaldehyde and formic acid that are well known as in vitro and in vivo toxicants (Seme et al, 1999; Treichel et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Prenatal exposure to methanol as a dopamine system sensitization model in C57BL/6J mice

et al. 2012

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Aims In this study, the effects of prenatal exposure to methanol (MeOH) on the nigrostriatal dopamine (NSDA) system were examined to determine if the interaction could sensitize this system, and serve as an underpinning for Parkinson's disease (PD) like changes that occur later in life. Methanol was studied because its toxicity resembles the symptoms of PD and the symptoms are relieved by l-dopa meaning that MeOH targets the NSDA system. Since fermentation and wood combustion are major sources for MeOH, the incidence of human encounters with MeOH is high. As a superior solvent and the precursor for formaldehyde, MeOH has a powerful and sometimes, irreversible impact on chemical processes, such as cross-linking proteins and nucleic acids. It may cause subthreshold changes that sensitizes the NSDA system to PD, that occur during aging. Main methods To study the prenatal effects of MeOH, pregnant C57BL/6J mice were administered 40 mg/kg MeOH by oral gavage during gestation days 8–12, twice daily. Twelve weeks after birth, behavior impairments were recorded. The striatum was dissected for the determination of tyrosine hydroxylase (TH), l-aromatic amino acid decarboxylase (LAAD), α-synuclein and levels of dopamine (DA) and its metabolites. Key findings MeOH reduced striatal TH and LAAD protein by 47% and 57% respectively and DA by 32%. Significance The results mean that in utero exposure to toxins similar to MeOH could sensitize the striatal system to changes that cause PD. This study may help identify strategies to block this type of in utero toxicity.

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Effect of methanol intoxication on spcific immune functions of albino rats

Cited by 14 publications

References 51 publications

Longer period of oral administration of aspartame on cytokine response in Wistar albino rats

Longer period of oral administration of aspartame on cytokine response in Wistar albino rats

Report of the meeting on Aspartame with National Experts

Prenatal exposure to methanol as a dopamine system sensitization model in C57BL/6J mice

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