2010
DOI: 10.1111/j.1369-1600.2010.00270.x View full text |Buy / Rent full text
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Abstract: Background Methamphetamine (METH) is an increasing popular and highly addictive stimulant associated with autonomic nervous system (ANS) dysfunction, cardiovascular pathology, and neurotoxicity. Heart rate variability (HRV) has been used to assess autonomic function and predict mortality in cardiac disorders and drug intoxication, but has not been characterized in METH use. We recorded HRV in a sample of currently abstinent individuals with a history of METH dependence compared to age- and gender-matched drug-… Show more

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“…First, since anxiety (Friedman and Thayer, 1998) and substance use disorders (Chen et al, 2015;Henry et al, 2012) are comorbidities often found in patients with MDD and can profoundly influence HRV measures (Chalmers et al, 2014;Quintana et al, 2013), both patients and controls were evaluated with a structured diagnostic interview to rule out any psychiatric co-morbidities and psychiatric disorders, respectively. Second, all participants underwent relevant laboratory investigations in addition to their physical health self-report.…”
Section: Discussionmentioning
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“…First, since anxiety (Friedman and Thayer, 1998) and substance use disorders (Chen et al, 2015;Henry et al, 2012) are comorbidities often found in patients with MDD and can profoundly influence HRV measures (Chalmers et al, 2014;Quintana et al, 2013), both patients and controls were evaluated with a structured diagnostic interview to rule out any psychiatric co-morbidities and psychiatric disorders, respectively. Second, all participants underwent relevant laboratory investigations in addition to their physical health self-report.…”
Section: Discussionmentioning
“…ECG results showed significant increase in heart rates of WT-METH, Tat-Saline, and Tat-METH compared to WT-Saline (Figure 2A). Heart rate variability (HRV) is associated with cardiac abnormalities including heart failure (Henry, 2012). This parameter was significantly reduced in WT-METH, Tat-Saline, and Tat-METH compared to WT-Saline (Figure 2B).…”
Section: Resultsmentioning
“…As atypical antipsychotics may interfere with QTc time, it could be that their use should be restricted in the acute phase, while the heart is still affected by amphetamines, to prevent increased risk of cardiovascular events [37,38]. In the immediate acute phase, the use of benzodiazepines will be a good alternative [39] and is recommended in guidelines [40,41].…”
Section: Drug Treatmentmentioning