Effect of metformin on serum lipid levels in hyperglycemic pregnant rats and their newborns

Abstract

Conclusion: Our findings suggest that the hyperglycemic pregnant rat model is a reliable model for gestational diabetes in human. Metformin is a safe and effective treatment for rat dams during gestational diabetes and their progenies. Therefore, it may be suggested that metformin can be used in treatment of gestational diabetes in pregnant women.