Effect of metallization on porphyrin photoacoustic response

Copper coordination-based conjugated polymer nanoparticles for synergistic photodynamic and chemodynamic therapy

“…1,2 As an essential therapeutic agent in PDT, photosensitizers can react with oxygen to produce singlet oxygen ( 1 O 2 ) and other reactive oxygen species (ROS), such as hydroxyl radicals (˙OH), hydrogen peroxide (H 2 O 2 ), and superoxide (O 2− ), which have strong oxidative power under irradiation and kill cancer cells. 3 However, the inadequate supply of oxygen in the tumor microenvironment severely limits the efficacy of photodynamic therapy. 4 In addition, glutathione (GSH) is overexpressed in cancer cells, and excessive GSH would significantly reduce the cytotoxicity of ROS during cancer treatment, thereby diminishing the therapeutic efficacy of PDT.…”

Supramolecular Self-Assembly of Porphyrin and Metallosurfactant as a Drug Nanocontainer Design

“…Porphyrins are widely used as macrocycles in supramolecular aggregates due to their distinctive π-conjugated architecture, excellent photosensitivity, and biochemical functionality [12,13]. The ability of porphyrins and their metal complexes to accumulate in cancer tissues has been long-standing [14][15][16]. Due to this affinity for cancer cells and their photosensitizing properties, they are widely used in photodynamic therapy of cancer for visualizing the location of tumor foci in the body [14,17] and their destruction [16,18,19].…”

“…The ability of porphyrins and their metal complexes to accumulate in cancer tissues has been long-standing [14][15][16]. Due to this affinity for cancer cells and their photosensitizing properties, they are widely used in photodynamic therapy of cancer for visualizing the location of tumor foci in the body [14,17] and their destruction [16,18,19]. The combination of this effective and at the same time sparing method of cancer treatment with chemotherapy holds great promise for improving the quality of anticancer treatment [20].…”

Sistemas de imagem e espectroscopia fotoacústica

“…A energia dissipada por processos não radioativos se transforma em calor. Portanto, a equação (2.7) pode ser reescrita de forma a incluir a eficiência da conversão de luz absorvida em sinal fotoacústico ( ) [91], [92].…”

“…A aquisição de imagens fotoacústicas multiespectrais utilizando a iluminação Este trabalho é reportado em um artigo com o título "Effect of metallization on porphyrin photoacoustic response", publicado pela Chemical Physics Letters [92].…”