Effect of Mercuric Compounds on the Maternal Transmission of Selenium in the Pregnant and Lactating Rat

Parízek, J; Ošťdalová, I.; Kalousková, J; Babický, A; Павлик, Л. Л.; Bíbr, B

doi:10.1530/jrf.0.0250157

Cited by 68 publications

(27 citation statements)

References 8 publications

(9 reference statements)

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“…Supplemental dietary selenium apparently replaces the selenium lost to intracellular mercury binding, thereby maintaining normal selenoenzyme activities. Maternal mercury exposure severely compromises the distribution of maternal selenium across the placenta (Parizek et al, 1971). However when maternal selenium status is enhanced by feeding rich levels of dietary selenium, toxic effects of methylmercury resulting in depressed selenium distribution and Selenium (Se) supplementation in the nutritionally relevant range counteracts methylmercury (MeHg) toxicity.…”

Section: Introductionmentioning

confidence: 99%

Dietary and tissue selenium in relation to methylmercury toxicity

et al. 2008

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Section: Introductionmentioning

confidence: 99%

Dietary and tissue selenium in relation to methylmercury toxicity

et al. 2008

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“…Earlier studies had shown that Na2SeOs decreases the toxicity of HgC12 injected into rats, possibly by complexation of mercury in the blood (9,10).…”

Section: Introductionmentioning

confidence: 99%

Proton magnetic resonance and Raman spectroscopic studies of methylmercury (II) complexes of inorganic anions

Rabenstein¹,

Tourangeau²,

Evans³

1976

Can. J. Chem.

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. Conlplexation of methylmercury(I1) by sulfate, selenate, carbonate, sulfite, selenite, thiocyanate, selenocyanate, sulfide, and selenide in aqueous solution has been studied by proton magnetic resonance and Raman spectroscopy. Formation constants were determined for the SO$, Se042-, C032-, S032-, Se032-, Se03H-, SCN-, and SeCN-complexes from the p H dependence of the chemical shift and the 199Hg-IH spin-spin coupling constant of the methyl group of CH3Hg(II) in solutions containing both CH3Hg(II) and ligand. The chemical shift and the 199Hg-lH spin-spin coupling constant of the CH3Hg(II) in each of the complexes were also obtained from the same measurements. Proton magnetic resonance parameters were measured for several complexes with sulfide and selenide. The ligand donor atom in each of the complexes was identified using the formation constants, the I99Hg-lH spin-spin coupling constant of the complexed methylmercury and the Raman spectral data. It is of particular interest that, in the selenite complex, the methylmercury is bonded to an oxygen atom whereas sulfur is the donor atom in the sulfite complex. Chem. 54,2517Chem. 54, (1976.On a CtudiC, par rmn et par spectroscopie Raman, la complexation du mCthylmercure(l1) par les ions sulfate, sCl6nate, carbonate, sulfite, sClCnite, thiocyanate, sClCnocyanate, sulfure et s6lCnure en solution aqueuse. On a dCterminC les constantes de formation des complexes du S0,2-, Se042-, C032-, S032-, Se032-, Se03H-, SCN-et SeCN-B partir de la d6pendance des dkplacenlents chimiques sur le pH et des constantes de couplage spin-spin 199Hg-lH des groupes mkthyles du CH3Hg(II) dans des solutions contenant B la fois du CH3Hg(II) et du ligand. On a aussi obtenu, B partir des mCmes mesures, les dCplacements chimiques et les constantes de couplage spin-spin 199Hg-lH du CH3Hg(II) dans chacun des complexes. On a mesurC les paramktres rmp de plusieurs complexes avec le sulfure et le selenure. On a identifie, dans chaque complexe, l'atome agissant comnle ligand donneur en faisant appel aux constantes de formation, aux constantes de couplage spin-spin 199Hg-HI du mCthylmercure complex6 et aux donnks des spectres Raman. I1 est important de noter que dans le complexe sClCnite, le mCthylmercure est liC L l'atome d'oxygkne alors que le soufre est l'atome donneur dans le complexe sulfite.[Traduit par le journal]

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“…Several authors (1,(8)(9)(10)(11) have demonstrated that if selenium is given in equimolar doses together with mercuric mercury, this has, in the rat, a protective effect against nephrotoxicity. Selenium administration is combined with a changed distribution of mercury, with increasing amounts in blood and in liver, and an increase in total body retention of mercury.…”

Section: Selenium Interaction With Mercuric Mercury Toxicitymentioning

confidence: 99%

Interaction between selenium and inorganic mercury.

Berlin¹

1978

Environ Health Perspect

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Data on mercury and selenium interaction in the mammalian body are reviewed. Experimental data from studies on rats show that selenium Interacts with mercury metabolism and toxicity after exposure to mercuric mercury. Autopsy data from workers exposed to mercury vapor indicate an association between mercury and selenium retention in the central nervous system, suggesting the formation of a mercuryselenium complex. In animal experiments, mercuric mercury interferes with selenium metabolism and toxicity. Available data do not, at present, permit deduction as to whether additional selenium Intake in man, exposed to mercury vapor or mercuric mercury, will have any effect, beneflcial or adverse.

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Effect of Mercuric Compounds on the Maternal Transmission of Selenium in the Pregnant and Lactating Rat

Cited by 68 publications

References 8 publications

Dietary and tissue selenium in relation to methylmercury toxicity

Dietary and tissue selenium in relation to methylmercury toxicity

Proton magnetic resonance and Raman spectroscopic studies of methylmercury (II) complexes of inorganic anions

Interaction between selenium and inorganic mercury.

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