Effect of melatonin in the prevention of post-operative adhesion formation in a rat uterine horn adhesion model

Abstract

This study showed that even single dose ME therapy was effective in the prevention of post- operative i.p. adhesion formation.

Effect of reactive oxygen species scavengers, antiinflammatory drugs, and calcium-channel blockers on carbon dioxide pneumoperitoneum-enhanced adhesions in a laparoscopic mouse model

“…In open surgery, ROS scavengers have been described as reducing adhesion formation in mice [45], rats [39,40,[42][43][44], and rabbits [41], but the effect is not consistent (e.g., vitamin E failed to decrease adhesion formation in rats) [90]. In our laparoscopic mouse model, we confirmed that ROS scavengers can decrease adhesion formation, although the overall effect was small.…”

“…In rats the same dose of SOD and catalase (i.e., 15,000 U/kg IV) decreased intraperitoneal adhesions [39]. Also for melatonin, the same IP dose of 10 mg/kg body weight was effective in rats [42].…”

“…For superoxide dismutase (SOD) and catalase,15,000 U/kg, administered intraperitonealy (IP) was chosen because this dose given intravenously (IV) was shown to be effective in rats [39]. For melatonin, 10 mg/kg IP was used because it was shown to be effective in rats [42]. For AA, 100 mg/kg IP was used because it was shown to be effective in guinea pigs [79].…”

“…During open surgery, many products have been demonstrated to decrease postoperative adhesion formation, including corticosteroids, [4][5][6][7], nonsteroidal antiinflammatory drugs (NSAIDs) [6,[8][9][10][11][12][13][14][15][16][17][18][19], fibrinolytic agents [20], surfactants [21][22][23][24][25], flotation agents and semisolid barriers [23,[26][27][28], mechanical barriers [26,[29][30][31][32], hormones [33], calcium-channel blockers [34][35][36][37][38], reactive oxygen species (ROS) scavengers [39][40][41][42][43][44][45], and antiangiogenesis therapy [46,47]. It should be stressed that these observations generally were reported with the use of only one drug in different models with di...…”

Polymers in the prevention of peritoneal adhesions

“…A variety of steroidal [8][9][10][11] and non-steroidal anti-inflammatory compounds [12][13][14][15][16] have been tested, as well as agents that interfere with specific cytokines [17] or vascular permeability [18], chemotherapeutic agents [19] and immunosuppressive drugs [20]. In a related vein, many agents that scavenge the free radicals generated by inflammation have been tested [21,22].…”